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Öğe THE EFFECT OF LAUREL AND THYMBRA ESSENTIAL OILS ON ANTIOXIDANT AND ANTIMICROBIAL PROPERTIES OF COLLAGEN HYDROLYSATE(Ars Docendi, 2012) Kaya, Durmus Alpaslan; Ferdes, Mariana; Badea, Nicoleta; Albu, Madalina GeorgianaThe aim of the present study was to determine the effect of essential oils on antioxidant and antimicrobial properties of collagen hydrolysate. The essential oils were obtained from Laurus nobilis L. (3,7%) and Thymbra spicata L. (4,1%) and they were characterized by GC-MS. Collagen hydrolysate obtained by biotechnological process was modified by essential oils and hydroalcoholic solutions with 0.25, 0.50, 1.0 and 2.0% thymbra and laurel oil were prepared. These hydroalcoholic solutions were characterized by antioxidant activity and antimicrobial activity against Escherichia coli. The antioxidant activity was more effective for the combination between hydrolysate and essential oils and increased with essential oils concentration increase. Based on its properties the hydroalcoholic solution with collagen hydrolysate and 2% thymbra oil proved the best antioxidant and antimicrobial activity in order to be use in medical, pharmaceutical, cosmetic, biotechnology and food industry.Öğe The effect of laurel and thymbra essential oils on antioxidant and antimicrobial properties of collagen hydrolysate(2012) Kaya, Durmuş Alpaslan; Ferdes, Mariana; Badea, Nicoleta; Albu, Madalina GeorgianaThe aim of the present study was to determine the effect of essential oils on antioxidant and antimicrobial properties of collagen hydrolysate. The essential oils were obtained from Laurus nobilis L. (3,7%) and Thymbra spicata L. (4,1%) and they were characterized by GC-MS. Collagen hydrolysate obtained by biotechnological process was modified by essential oils and hydroalcoholic solutions with 0.25, 0.50, 1.0 and 2.0% thymbra and laurel oil were prepared. These hydroalcoholic solutions were characterized by antioxidant activity and antimicrobial activity against Escherichia coli. The antioxidant activity was more effective for the combination between hydrolysate and essential oils and increased with essential oils concentration increase. Based on its properties the hydroalcoholic solution with collagen hydrolysate and 2% thymbra oil proved the best antioxidant and antimicrobial activity in order to be use in medical, pharmaceutical, cosmetic, biotechnology and food industry. © 2012 University of Bucharest.Öğe The effect of lavandula essential oils on release of niflumic acid from collagen hydrolysates(Korean Institute Chemical Engineers, 2016) Ghica, Mihaela Violeta; Albu, Madalina Georgiana; Kaya, Durmus Alpaslan; Popa, Lacramioara; Ozturk, Sevket; Rusu, Laura-Cristina; Dinu-Pirvu, CristinaThe aim of this paper is to design and characterize some drug delivery systems (DDS) based on collagen hydrolysates (H), niflumic acid as a non-steroidal anti-inflammatory model drug and two essential oils of Lavandula officinalis L. (LO) and Lavandula stoechas L. subsp. Stoechas (LS), for use in healing cutaneous wounds with post-lesion inflammatory response. The essential oils are characterized by GC-MS. The wettability capacity of collagen hydrolysate powders was assessed by contact angle measurement. Niflumic acid release was investigated using a modified Franz diffusion cell, and the diffusion coefficient, time-lag and drug flux were determined. The kinetic parameters were found to be influenced by different concentrations and types of essential oils. These therapeutical products, based on collagen hydrolysates and synergistic drug associations, could have potential biomedical application in wound healing treatment.Öğe The Effect of Lavender Essential Oils on Collagen Hydrolysate(Chiminform Data S A, 2013) Inan, Memet; Kaya, Durmus Alpaslan; Albu, Madalina GeorgianaThe aim of this study was to develop new natural compounds based on collagen hydrolysate modified with lavender essential oils. The essential oils were extracted by hydrodistillation from aerial parts of Lavender officinalis L. and Lavender stoechas L. subsp. stoechas with the yield of 3.0 and 3.6% respectively. The chemical composition determined by GC-MS analyses showed that fenchone (45.47%), 1.8 cineol (19.47%) and camphor (17.23%) were the main components for L. stoechas oil, while for L. officinalis, linalool (28.00%) linalyl acetate (43.96%) and camphor (5.94%) were found in high concentrations. The main groups of essential oils were identified also by FT-IR. Natural compounds with 75:25, 50:50 and 25:75 ratios (w/w) were prepared by collagen hydrolysate with 6000 Da and lavender essential oils. The modifications of collagen hydrolysate as a result of lavender essential oil interactions were determined by FT-IR. The results showed that L. stoechas essential oil was linked stronger on collagen due to higher content of ketones comparing with L. officinalis which is rich in alcohols and esters. The essential oils were bonded on side chain of amino acids from collagen hydrolysate. The new obtained compounds could be used as basic natural ingredients in medical, pharmaceutical and cosmetic fields, as they are products with added value, keeping the therapeutic properties of both collagen and essential oils.Öğe THE PROPERTIES OF TWO NATURAL ZEOLITES MODIFIED WITH OREGANO ESSENTIAL OIL(Serban Solacolu Foundation, 2013) Kaya, Durmus Alpaslan; Vuluga, Zina; Nicolae, Cristian Andi; Radovici, Constantin; Albu, Madalina GeorgianaThe aim of this study was to prepare zeolites modified with oregano essential oil and to establish their morphological and thermal properties as well as the release ability of essential oil from zeolites. The chemical composition of oregano oil was determined by GS-MS. The crystalline structure and chemical composition of two natural zeolites were performed by X-ray diffraction (XRD) and X-ray fluorescence (EDXRF). Both natural zeolites presented similar structure with clinoptilolite type. The thermal characteristics of oregano oil, zeolites and their combination were carried out by thermogravimetric analyses (TGA). The oregano oil was loaded in zeolite in order to improve its stability. It gradually evaporated so that the percentage of oil removed after 2h from zeolites was two times lower than itself evaporation. This property allows to the natural combination between zeolite and essential oil to be used as basic material in medical, pharmaceutical, cosmetic and food industry.
