The effect of lavandula essential oils on release of niflumic acid from collagen hydrolysates
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Date
2016
Journal Title
Journal ISSN
Volume Title
Publisher
Korean Institute Chemical Engineers
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
The aim of this paper is to design and characterize some drug delivery systems (DDS) based on collagen hydrolysates (H), niflumic acid as a non-steroidal anti-inflammatory model drug and two essential oils of Lavandula officinalis L. (LO) and Lavandula stoechas L. subsp. Stoechas (LS), for use in healing cutaneous wounds with post-lesion inflammatory response. The essential oils are characterized by GC-MS. The wettability capacity of collagen hydrolysate powders was assessed by contact angle measurement. Niflumic acid release was investigated using a modified Franz diffusion cell, and the diffusion coefficient, time-lag and drug flux were determined. The kinetic parameters were found to be influenced by different concentrations and types of essential oils. These therapeutical products, based on collagen hydrolysates and synergistic drug associations, could have potential biomedical application in wound healing treatment.
Description
Keywords
Collagen Hydrolysate, Niflumic Acid, Lavandula Essential Oils, Release Kinetics
Journal or Series
Korean Journal of Chemical Engineering
WoS Q Value
Q2
Scopus Q Value
Q2
Volume
33
Issue
4
