The effect of lavandula essential oils on release of niflumic acid from collagen hydrolysates
Yükleniyor...
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Korean Institute Chemical Engineers
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of this paper is to design and characterize some drug delivery systems (DDS) based on collagen hydrolysates (H), niflumic acid as a non-steroidal anti-inflammatory model drug and two essential oils of Lavandula officinalis L. (LO) and Lavandula stoechas L. subsp. Stoechas (LS), for use in healing cutaneous wounds with post-lesion inflammatory response. The essential oils are characterized by GC-MS. The wettability capacity of collagen hydrolysate powders was assessed by contact angle measurement. Niflumic acid release was investigated using a modified Franz diffusion cell, and the diffusion coefficient, time-lag and drug flux were determined. The kinetic parameters were found to be influenced by different concentrations and types of essential oils. These therapeutical products, based on collagen hydrolysates and synergistic drug associations, could have potential biomedical application in wound healing treatment.
Açıklama
Anahtar Kelimeler
Collagen Hydrolysate, Niflumic Acid, Lavandula Essential Oils, Release Kinetics
Kaynak
Korean Journal of Chemical Engineering
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
33
Sayı
4
