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  • Küçük Resim
    Öğe
    Antimicrobial Activity of Some Thiourea Derivatives and Their Nickel and Copper Complexes
    (Mdpi, 2009) Arslan, Hakan; Duran, Nizami; Borekci, Gulay; Ozer, Cemal Koray; Akbay, Cevdet
    Five thiourea derivative ligands and their Ni2+ and Cu2+ complexes have been synthesized. The compounds were screened for their in vitro anti-bacterial activity using Gram-positive bacteria (two different standard strains of Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Streptococcus pyogenes, Bacillus cereus) and Gram-negative bacteria (Esherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae, Proteus vulgaris, Enterobacter aerogenes) and in vitro anti-yeast activity (Candida albicans, Candida krusei, Candida glabrata, Candida tropicalis, Candida parapsilosis). The minimum inhibitory concentration was determined for all ligands and their complexes. In vitro anti-yeast activity of both ligands and their metal complexes is greater than their in vitro anti-bacterial activity. The effect of the structure of the investigated compounds on the antimicrobial activity is discussed.
  • Küçük Resim
    Öğe
    Synthesis, characterization and antimicrobial activities of transition metal complexes of N,N-dialkyl-N?-(2-chlorobenzoyl)thiourea derivatives
    (Taylor & Francis Ltd, 2006) Binzet, Gun; Arslan, Hakan; Floerke, Ulrich; Kuelcue, Nevzat; Duran, Nizami
    N, N-di-n-propyl-N'-(2-chlorobenzoyl) thiourea (HL1) (1), N, N-diphenyl-N'-(2-chlorobenzoyl) thiourea (HL2) (2), and their Ni-II, Co-II, Cu-II, Zn-II, Pt-II, Cd-II and Pd-II complexes have been synthesized and characterized. HL1 and its copper complex were characterized by single-crystal X-ray diffraction methods. The ligands coordinate as bidentates yielding essentially neutral complexes of the type [ML2]. The complexes were screened for their in vitro antibacterial, antifungal activities and toxicity. All compounds showed antimicrobial activity, but antibacterial efficacy is greater than antifungal activity.
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    Öğe
    Thermal behaviour and antimicrobial activity of novel series of benzoylthiourea derivatives
    (Chemical Publishing Co., 2006) Arslan, Hakan; Duran, Nizam; Şahin, Nefise Özlen; Külcü, Nevzat
    Thermal behaviour and antimicrobial activity was investigated for a series of thiourea derivatives. The thermal behaviour of the compounds on heating up to 1000 K in nitrogen atmosphere was examined by thermogravimetry and differential thermal analysis. The compounds decompose in one or two stages. GC-MS combined system was used to identify the products during pyrolytic decompositions. The kinetic analysis of the thermogravimetric data was performed using the Coats-Redfern and Horowitz-Metzger methods. The antibacterial activities of these thiourea derivatives were investigated for three Gram positive (Enterococcus faecalis, Staphylocccus aureus and Staphylocccus epidermidis) and two Gram negative (Escherichia coli, Pseudomonas aeruginosa) bacteria by employing broth microdilution method and subsequently, inhibitory activity against yeast-like fungi (Candida albicans, Candida krusei, Candida glabrata and Candida parapsilosis) was also determined. Only three of the compounds showed antimicrobial activity and that were at a moderate level. None of them exhibited sufficient antifungal activity to become a drug candidate.