Thermal behaviour and antimicrobial activity of novel series of benzoylthiourea derivatives
[ N/A ]
Tarih
2006
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Chemical Publishing Co.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Thermal behaviour and antimicrobial activity was investigated for a series of thiourea derivatives. The thermal behaviour of the compounds on heating up to 1000 K in nitrogen atmosphere was examined by thermogravimetry and differential thermal analysis. The compounds decompose in one or two stages. GC-MS combined system was used to identify the products during pyrolytic decompositions. The kinetic analysis of the thermogravimetric data was performed using the Coats-Redfern and Horowitz-Metzger methods. The antibacterial activities of these thiourea derivatives were investigated for three Gram positive (Enterococcus faecalis, Staphylocccus aureus and Staphylocccus epidermidis) and two Gram negative (Escherichia coli, Pseudomonas aeruginosa) bacteria by employing broth microdilution method and subsequently, inhibitory activity against yeast-like fungi (Candida albicans, Candida krusei, Candida glabrata and Candida parapsilosis) was also determined. Only three of the compounds showed antimicrobial activity and that were at a moderate level. None of them exhibited sufficient antifungal activity to become a drug candidate.
Açıklama
Anahtar Kelimeler
Antimicrobial activity, Benzoylthiourea derivative, Thermal analysis, Thiourea
Kaynak
Asian Journal of Chemistry
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
18
Sayı
3
