Thermal behaviour and antimicrobial activity of novel series of benzoylthiourea derivatives

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dc.authorscopusid57200576372
dc.authorscopusid35612683100
dc.authorscopusid8644922600
dc.authorscopusid6602088323
dc.contributor.authorArslan, Hakan
dc.contributor.authorDuran, Nizam
dc.contributor.authorŞahin, Nefise Özlen
dc.contributor.authorKülcü, Nevzat
dc.date.accessioned2024-09-19T15:43:33Z
dc.date.available2024-09-19T15:43:33Z
dc.date.issued2006
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThermal behaviour and antimicrobial activity was investigated for a series of thiourea derivatives. The thermal behaviour of the compounds on heating up to 1000 K in nitrogen atmosphere was examined by thermogravimetry and differential thermal analysis. The compounds decompose in one or two stages. GC-MS combined system was used to identify the products during pyrolytic decompositions. The kinetic analysis of the thermogravimetric data was performed using the Coats-Redfern and Horowitz-Metzger methods. The antibacterial activities of these thiourea derivatives were investigated for three Gram positive (Enterococcus faecalis, Staphylocccus aureus and Staphylocccus epidermidis) and two Gram negative (Escherichia coli, Pseudomonas aeruginosa) bacteria by employing broth microdilution method and subsequently, inhibitory activity against yeast-like fungi (Candida albicans, Candida krusei, Candida glabrata and Candida parapsilosis) was also determined. Only three of the compounds showed antimicrobial activity and that were at a moderate level. None of them exhibited sufficient antifungal activity to become a drug candidate.en_US
dc.identifier.endpage1718en_US
dc.identifier.issn0970-7077
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-33745851544en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1710en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14406
dc.identifier.volume18en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherChemical Publishing Co.en_US
dc.relation.ispartofAsian Journal of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntimicrobial activityen_US
dc.subjectBenzoylthiourea derivativeen_US
dc.subjectThermal analysisen_US
dc.subjectThioureaen_US
dc.titleThermal behaviour and antimicrobial activity of novel series of benzoylthiourea derivativesen_US
dc.typeArticleen_US

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