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Öğe Acquired lymphangioma circumscriptum of the vulva secondary to radiotherapy(Int Scientific Literature, Inc, 2010) Akansu, Bulent; Atik, Esin; Altintas, Suleyman; Serarslan, Gamze; Dolapcioglu, Kenan; Canda, M. SerefettinBackground: Lymphangioma circumscriptum is a benign lesion of the lymphatics. The primary form of the disease is generally seen at birth or during childhood, whereas the secondary (acquired) form is a result of radiotherapy or a surgical procedure. Case Reoprt: A 38-year-old female patient was admitted to hospital with the complaint of skin eruptions on her vulva. About 10 years before she had had a total abdominal hysterectomy and bilateral salpingo-oophorectomy because of squamous cell carcinoma of the cervix and radiotherapy had been performed to the perineal region after surgery. Papillary-like lesions on the skin were seen in gross examination. These lesions were diagnosed as acquired lymphangioma circumscriptum by microscopy. Conclusions: Acquired lymphangioma is a benign lesion which can appear many years after radiotherapy. Several pre-malignant and malignant lesions can also occur following radiotherapy in this region. Therefore it is important for the clinician and pathologist to be aware of this situation and be careful when making the differential diagnosis.Öğe Antibacterial activity of propolis against MRSA and synergism with topical mupirocin(Mary Ann Liebert, Inc, 2007) Onlen, Yusuf; Duran, Nizami; Atik, Esin; Savas, Lutfu; Altug, Enes; Yakan, Selvinaz; Aslantas, OzkanObjectives: The aim of the present study was to investigate the activity of the propolis and its combinations with mupirocin against methicillin-resistant Staphylococcus aureus (MRSA) in nasal carriage. Methods: This study was carried out between June and August 2005. To infect nares of the rabbits, MRSA ( ATCC 33591) strain was used. Minimum inhibitory concentration was determined according to National Committee for Clinical Laboratory Standards. Each inoculum was prepared in the same medium at a density adjusted to a 0.5 McFarland turbidity standard (10(5) colony- forming units [cfu]/ mL) and diluted 1: 100 for the broth microdilution procedure. Ten microliters (10 mu L) (10(5) cfu/mL) of the bacterial suspension containing approximately 1000 cfu of MRSA was administered with sterile microsyringe through both nostrils of each rabbit. Ninety-six ( 96) hours after inoculation, the presence of infection was confirmed by using bacterial cultures. Twenty-six young New Zealand rabbits were randomly divided into 4 groups. Each treatment group ( 1, 2, and 3) included 7 rabbits and control group ( group 4) included 5 rabbits. Group 1 was treated with topical mupirocin + ethanolic extract of propolis drops, group 2 received topical mupirocin, group 3 was administered ethanolic extract of propolis drops, and the control group ( group 4) was only treated with phosphate-buffered solution drops for 7 days. At the end of study, nasal cultures and smears were obtained for bacterial count and cytologic examination. Results: The colony numbers of bacteria in group 1 were determined to be significantly lower than in group 2 (p= 0.0001), group 3 (p = 0.0001), and group 4 ( p = 0.0001). The mean bacterial cell counts of groups 1- 4 were 360.2 +/- 52.4 cfu/ mL, 4120.6 +/- 860.4 cfu/ mL, 5980.8 +/- 1240.6 cfu/ mL, and 11500.0 +/- 2568.4 cfu/ mL, respectively. Mupirocin + propolis administration ( group 1) resulted in a significant reduction in the polymorphonuclear leukocyte (PMNL) count in the mucous membranes of rabbits compared with the other treatment groups ( p < 0.05). Conclusions: Propolis addition to mupirocin regimen was found to result in more profound reduction in bacterial cell count and inflammatory response compared with the rest of the treatment modalities.Öğe An atypical bladder diverticulum presented with recurrent peritonitis : Case report(2011) Temiz, Abdulkerim; Akçora, Bülent; Atik, EsinMesane divertikülleri detrusor kasının doğuştan zayıflığından kaynaklanır. Sıklıkla divertikül içindeki üriner staz sunucu gelişen idrar yolları enfeksiyonu ile kendini gösterir. Mesane çıkım tıkanıklığı, alt ekstremitede siyanoz, intestinal tıkanıklık, üreteral tıkanıklık gibi divertikülün doğrudan basısı sonucu ve divertikülün kendiliğinden rüptüre sonucu gelişen peritonit gibi farklı klinik tablolara neden olabilmektedir. Bu yazıda, perfore apandisiti taklit eden ve perforasyon olmadan tekrarlayan jeneralize peritonite neden olan mesane divertikülü olan bir olgu sunuldu.Öğe An atypical bladder diverticulum presented with recurrent peritonitis: case report(Turkish Assoc Trauma Emergency Surgery, 2011) Temiz, Abdulkerim; Akcora, Bulent; Atik, EsinBladder diverticula develop from congenital detrusor muscle defect and frequently present with urinary tract infection, which occurs as a result of urinary stasis in the diverticula. Different clinical presentations, such as bladder outlet obstruction, cyanosis of the lower extremities, intestinal obstruction, ureteral obstruction (which may occur due to direct diverticular compression), and peritonitis due to spontaneous rupture of the diverticula, were reported previously. Here, we report a case with the diagnosis of bladder diverticulum that caused recurrent generalized peritonitis without perforation and mimicked perforated appendicitis.Öğe Baboon Syndrome Induced by Amoxycillin(Turkish Soc Dermatology Venerology, 2006) Serarslan, Gamze; Atik, EsinBaboon syndrome is a rarely seen type of systemic contact dermatitis and characterized by erythema of the gluteal and genital area and in the flexural areas. Baboon syndrome occurs after ingestion or systemic absorption of contact allergen in individuals previously sensitized by topical exposure to the same allergen. However, this eruption may occur with drugs taken systemically without previous sensitization. It is also an uncommon condition in children. We report a 9-year-old patient with Baboon syndrome induced by amoxycillin without known previous sensitization.Öğe Benin, premalin ve malin lezyonlarda hücre proliferasyon belirleyicilerinin ekspresyonu ve insan papilloma virus izolasyonu(2007) Serarslan, Gamze; Atik, Esin; Otlu, Barış; Bakariş, Sevgi; Durmaz, RızaAMAÇ: Bu çalışmada çeşitli benin, premalin ve malin deri lezyonlarında proliferasyon belirleyicilerinin rolü ve bu lezyonlarda insan papilloma virusu (HPV) pozitifliğinin saptanması amaçlandı. GEREÇ-YÖNTEM: Çalışmaya, parafin bloktaki 62 doku [12 seboreik keratoz (SK), 10 keratoakantom (KA), 8 aktinik keratoz (AK), 22 bazal hücreli karsinom (BHK) ve 10 skuamöz hücreli karsinom (SHK)] alındı. Doku örnekleri, Ki-67, p21 ve bcl-2 ekspresyonunu belirlemek amacıyla, immünohistokimyasal yöntemle çalışıldı. HPV DNA’sını tespit etmek için PCR uygulandı. BULGULAR: BHK tanısı almış olan iki dokuda HPV (tip-16) pozitifliği saptandı. Lezyonlarda Ki-67, p21 ve bcl-2 ekspresyonu sırası ile şu şekildeydi: KAÖğe A Case of Nonhealing Leg Ulcer: Basal Cell Carcinoma(Galenos Yayincilik, 2008) Balci, Didem Didar; Yenin, Julide Zehra; Atik, Esin; Akansu, BulentA 75-year-old woman was admitted to our outpatient clinic with a three-year history of a painless, nonhealing ulcer located on the left lower leg. She had no response to previous therapy with local wound care. Skin examination revealed an ulcer 2.7 x 3.7 cm in size, and the surrounding skin showed minimal erythema. The surface of the ulcer demonstrated shiny granulation tissue. Biopsy of the ulcer edge and base showed basal cell carcinoma. Venous Doppler ultrasonography and dermatological examination did not reveal chronic venous insufficiency. Basal cell carcinomas rarely arise from previous long-term ulcers or developing de novo. We suggest that patients who develop non-healing leg ulcers, should be examined for basal cell carcinoma.Öğe The Co-Existence of Vulvar Lichen Sclerosus, Ulcerated Calcinosis Cutis, and Dermatomyositis: Coincidence or Immunological Mechanism?(Korean Dermatological Assoc, 2011) Balci, Didem Didar; Celik, Ebru; Sarikaya, Gokhan; Yenin, Julide Zehra; Atik, EsinCalcinosis cutis is a condition characterized by the deposition of calcium salts in the skin and subcutaneous tissues, and patients suffering from it encounter various connective tissue disorders, such as dermatomyositis (DM), scleroderma, and systemic lupus erythematosus. Although calcinosis cutis is frequently accompanied by juvenile dermatomyositis, rare cases have been reported in adult patients with DM. On the other hand, lichen sclerosus (LS) is a chronic inflammatory disease of the skin and mucosal surfaces. In the present report, we present a rare case of a 71-year-old patient with DM accompanied by ulcerated calcinosis cutis and vulvar LS. (Ann Dermatol 23(S3) S375 similar to S379, 2011)Öğe Çocuklarda kutanöz mastositoz : Demografik, klinik ve histopatolojik bulgular(2008) Serarslan, Gamze; Atik, Esin; Canda, ŞerafettinAmaç: Mastositoz, bir veya daha çok organda mast hücrelerinin çoğalması ve birikmesi ile karakterize bir hastalıktır. Deri, en sık tutulan organdır. Bu çalışmada kutanöz mastositozu olan çocuk hastaların demografik, klinik ve histopatolojik bulgularının sunulması ve literatürün gözden geçirilmesi amaçlandı. Yöntemler: Kutanöz mastositoz tanısı alan 14 çocuk hastanın demografik, klinik ve histopatolojik verileri geriye dönük olarak analiz edildi. Bulgular: On bir hastada (%78.6) ürtikerya pigmentoza, iki hastada (%14.3) mastositoma ve bir hastada (%7.1) ürtikerya pigmentoza ve mastositoma birlikteliği vardı. Hastaların %64.3’ünde hastalık hayatın ilk bir yılı içerisinde başlamıştı. Erkek-kız oranı 1:1.8 idi. Ürtikerya pigmentozalı hastalarda lezyonlar en sık gövde ve ekstremite yerleşimli, mastositomalı hastalarda ise gövde yerleşimliydi. Darier işareti hastaların %92’sinde bulunmaktaydı. Aile öyküsü olan bir olgu vardı. En sık saptanan şikayet kaşıntı idi. Sonuç: Sonuçlarımız, kızların sayısındaki üstünlük dışında genel olarak daha önce bildirilen çalışmalar ile uyumluydu.Öğe Coexistence of Acral Syringomas and Multiple Trichoepitheliomas on the Face(Sage Publications Inc, 2009) Balci, Didem Didar; Atik, Esin; Altintas, SuleymanBackground: An extremely rare variant of syringoma is an acral form, which affects the upper extremities as an isolated finding. The acral syringomas may also be associated with syringomas on the feet or usual distribution around the eyelids. Of the eight previously documented cases of acral syringomas, all were located on the dorsal aspect of the upper extremities (fingers, hand, wrist, or forearm) dominantly. Objective: We report a 41-year-old woman who presented with multiple flesh-colored to reddish brown papules on the inner aspect of the forearms and many pearly, small papules on the periorbital regions. Results: The clinical picture and histopathology indicated the coexistence of acral syringomas and multiple trichoepitheliomas on the face. Conclusion: To the best of our knowledge, this is the first case of acral syringomas coexisting with multiple trichoepitheliomas.Öğe Diagnostic approach and significance of inducible nitric oxide positivity in human cutaneous leishmaniasis caused by leishmania tropica(Blackwell Publishing, 2007) Atik, Esin; Kuk, Salih; Inandi, TacettinAim To determine the usefulness of polymerase chain reaction (PCR) in the diagnosis of leishmaniasis and to emphasize the importance of inducible nitric oxide (iNOS). Materials and Methods Twenty-nine patients with cutaneous leishmaniasis diagnosed according to clinical criteria who live in rural areas of Antakya-Hatay/Turkey were included in this study. Twenty-five patients free of leishmaniasis were accepted as a control group. Punch biopsies and smears were obtained from lesions of the patients in the study group. Half of each punch biopsy specimen was processed in routine tissue processing. After routine tissue processing hematoxylin-eosin and iNOS immunohistochemical staining were applied. The remaining half of the biopsy specimens was studied by PCR method. INOS-positive stained macrophages were determined. Results The positive detection rates in 29 cases of cutaneous leishmaniasis (CL) were 96.5% by PCR, 86.2% by direct microscopic evaluation of biopsy and 58.6% by direct visualization of smear in this study. iNOS reaction was mildly positive in three cases, moderately positive in six cases and strongly positive in 20 cases. Conclusion iNOS yielded positive reaction in all cases but this positivity showed differences with respect to the age of the lesions or the effect of iNOS on the immune mechanism. This reveals an inverse correlation between iNOS reactivity and duration of lesion (Spearman correlation r = -0.53, P = 0.003). There was no correlation between iNOS reactivity and patient age (Spearman correlation: r = 0.13, P = 0.5). In terms of gender, there was no association with iNOS.Öğe Effect of 1-deamino 8-D-arginine vasopressin spray on nasal cytology and mucociliary clearance in patients with nocturnal enuresis(Elsevier Ireland Ltd, 2006) Akoglu, Ertap; Goeruer, Sadik; Atik, Esin; Okuyucu, Semsettin; Sanguen, OezlemObjective: To determine any possible adverse effect of 1-deamino 8-D-arginine vasopressin (DDAVP) spray on nasal cytology and mucociliary clearance in patients with nocturnal enuresis. Methods: Twenty-two children aged 6-16 enrolled in the study. Epithelial surface cells samples were taken from the nasal mucosa and mucociliary clearance time was calculated before and 1 and 6 months after administration of DDAVP spray. Results: No qualitative changes in the epithelial surface cells and mucociliary clearance time were observed at 1 and 6 months after therapy. Conclusion: Based on the findings of the present study, DDAVP spray can be used for 6 months in children without apparent risk of damage to the epithelial surface cells and mucociliary clearance time. (C) 2006 Elsevier Ireland Ltd. Atl. rights reserved.Öğe The effect of caffeic acid phenethyl ester (CAPE) on histopathological changes in testicular ischemia-reperfusion injury(Academic Press Ltd Elsevier Science Ltd, 2006) Atik, Esin; Gorur, Sadik; Kiper, Ahmet NamikTesticular torsion causes an enhanced formation of reactive oxygen species which contributes to the pathophysiology of ischemia-reperfusion injury in the testis. We evaluated here the effect of caffeic acid phenethyl ester (CAPE), a new antioxidant and anti-inflammatory agent on histopathological changes in testicular ischemia-reperfusion injury. Adult male Wistar rats were divided into six groups of five each: control group I (n = 5), sham operation group 2 (n = 5), torsion/detorsion (T/D) group 3 (it = 5), T/D + saline group 4 (n = 5), T/D + CAPE group 5 (n = 5) and T/D + CAPE group 6 (n = 5). Group I served to determine baseline values of histopathological parameters, group 2 animals that underwent sham operation served as a control, while groups 3-6 animals were subjected to left unilateral torsion (2 h) and detorsion (24 h) periods. All the groups were sacrified 24 h later except group 6. CAPE was injected 2 days with the same dose to the group 6 and it was sacrified 48 h later. One testis removed and fixed in Bouin's solution. After routine tissue processing myeloperoxidase (MPO) and inducible nitric oxide synthase (iNOS) immunohistochemical methods were studied from paraffin embedded tissues. Treating rats with CAPE (applied at 10 mu mol/kg, 30 min prior to T/D) attenuated the testicular injury and as well as the tissue levels of MPO. At the same time testis tissue showed a decrease in iNOS activity. Our results suggest that CAPE treatment have a protective role on testicular T/D and this effect may be due to inhibiting the neutrophil mediated cellular injury. (c) 2006 Elsevier Ltd. All rights reserved.Öğe Effectiveness of mesalamine and propolis in experimental colitis(Springer, 2007) Aslan, Ahmet; Temiz, Muhyittin; Atik, Esin; Polat, Gurbuz; Sahinler, Nuray; Besirov, Eimir; Aban, NedimThis study was conducted to investigate the effects of propolis and mesalamine on experimental colitis in rats. Distal colitis was induced in rats by intracolonic instillation of 2 mL of 4% acetic acid. The animals were randomly assigned to 5 groups: group 1, control, (n=8); group 2, colitis, received no treatment (n=8); group 3, colitis+mesalamine, 2 mL once a day via an enema (n=8); group 4, colitis+propolis, 600 mg/kg once a day via intragastric lavage (n=8); and group 5, colitis+ mesalamine+propolis for 1 wk (n=8). Levels of nitric oxide were statistically significantly different in comparisons between groups 1 and 2, groups 2 and 3, and groups 4 and 5. Malondialdehyde levels were significantly different when group 2 was compared with groups 3, 4, and 5. A significant difference was observed when group 3 was compared with group 4 for myeloperoxidase. Most propolis-treated rats had normal histology; mesalamine-treated and propolis+mesalamine-treated rats had inflammatory cell infiltration at rates of 50% and 33%, respectively. The investigators concluded that propolis and mesalamine are efficient independently and in combination, but that their combined effect was not observed to be additive in experimental colitis.Öğe Effects of a Single Application of Extractum Cepae on the Peritendinous Adhesion An Experimental Study in Rabbits(Lippincott Williams & Wilkins, 2010) Dogramaci, Yunus; Kalacı, Aydıner; Atik, Esin; Esen, Erdinc; Altug, Muhammet Enes; Onel, Ercument; Koc, AhmetPeritendinous adhesion is an important cause of poor functional outcome after flexor tendon repair. The objective of this study was to investigate the effect of a single intraoperative application of extractum cepae, an extract of dietary onion, on the peritendinous adhesion, using a rabbit model of flexor tendon injury. The first, second, and third digits of the right hind paw of 18 rabbits were used for tendon operations. A standard partial division of the synovial sheath and flexor tendon was done at zone II to stimulate the adhesion formation. In the treatment group (n = 9 rabbits, 27 tendons), the flexor tendon sheath was treated with 50 mg/mL of extractum cepae which was applied locally and allowed to infiltrate for 5 minutes, the skin was sutured without suturing the sheath and the tendons. The same operation was done for the control group (n = 9 rabbits, 27 tendons) and 1 mL of normal saline solution was applied locally. Biomechanical and histologic evaluations of the specimens were done after 3 weeks. Tendons from the first toes were used for biomechanical studies. The second and third toe tendons were used for histopathologic evaluation. We have compared the peritendinous adhesions and the ultimate forces in the control and treated tendons. There were no statistically significant differences between the 2 groups with respect to the ultimate loads. Adhesion formation was absent in 1 tendon (5.5%), slight in 8 (44.4%), moderate in 6 (33.3), and severe in 3 tendons (16.7%) in the extractum cepae treated group (n = 18); while in the control group (n = 18), it was absent in 1 tendon (5.5%), slight in 1 tendon (5.5%), moderate in 3 (16.6%), and severe in 13 (72.4%) tendons. There was a significant reduction (P = 0.01) in the peritendinous adhesion in the treated group comparing to the control group. The problem of adhesion formation may be minimized using a single intraoperative application of extractum cepae.Öğe The effects of gokshura, Tribulus terrestris on sex reversal of guppy, Poecilia reticulata(Asian Network for Scientific Information, 2007) Çek, Şehriban; Turan, Funda; Atik, EsinThis study examined the effects of Tribulus terrestris (TT) on sex reversal in guppy, Poecilia reticulata. The objective of this study was to introduce a new environmentally friendly method for masculinization in P. reticulata. Since male guppy has higher commercial value than female. TT is a natural, non-toxic herb which helps enhance testosterone levels in human and animals. It was prepared in a laboratory in France. Different concentration (0.0, 0.05, 0.1 and 0.15 g L-1) of TT was investigated for sex reversal in the Poecilia reticulata. TT extract was administered by immersion of newly born offspring once weekly for two months. Among the dosages used in the present study 0.15 g L-1 TT was the most effective dosage that ensured maximum male ratio (80%, p<0.01). Although, sex ratios of 0.05 and 0.1 g L-1 TT were not significantly different from the expected 1:1 ratio, in these two groups treatment with TT also result in higher number of males (58.25 and 59.77%, respectively), than control (p>0.05). Total survival rates in all treatments and control were uniformly high ranging from 83 to 87% (p>0.05). It is concluded that TT has no negative effect on survival rate of P. reticulata. All groups of TT-treated fish exhibited successful growth acceleration comparing to the control group, but only TT treatment at the concentration of 0.15 and 0.1 g L-1 TT significantly improved growth rate of P. reticulata (p<0.01). Histological examinations revealed that testes of fish treated with TT-extract contained all stages of spermatogenesis. Sex reversal in P. reticulata demonstrated that TT treated new-born progenies showed successful sex reversal, spermatogenesis and better growth rate than untreated progenies. © 2007 Asian Network for Scientific Information.Öğe The effects of increased cAMP content on inflammation, oxidative stress and PDE4 transcripts during Brucella melitensis infection(Elsevier Sci Ltd, 2008) Erdogan, Suat; Aslantas, Ozkan; Celik, Sefa; Atik, EsinCyclic AMP (cAMP) is a key intracellular second messenger which at increased levels has been shown to have anti-inflammatory and tissue-protective effects. Its concentration is determined by the activities of both adenylate cyclase (AC) and the phosphodiesterase (PDE) enzymes. The aim of this study was to compare the effects of increased cAMP and glucocorticoid dexamethasone administration on B. melitensis-induced lipid peroxidation, Brucella suppressed antioxidant enzyme activities and PDE4 transcripts in rats. Intracellular cyclic AMP level was elevated by two different approaches; activation of AC and inhibition of PDE activities. Rats were inoculated with B. melitensis for seven days then a single dose of nonselective PDE inhibitor 3-isobutyl-1-methylxanthine.(IBMX), the adenylate cyclase activator forskolin and dexamethasone were administrated to each infected group, and animals were challenged for 48 h. Brucella-induced lipid peroxidation was significantly reduced by the cAMP elevating agents as well as dexamethasone administration in plasma, liver and spleen. The antioxidant enzymes glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities were significantly decreased by the pathogen. Whilst suppressed GSH-Px activity was reversed by cAMP elevating agents, SOD activity was not restored. Superoxide generating enzyme xanthine oxidase activity was not altered at the end of the infection period. Brucella infection increased plasma IL-12 level and this effect was also suppressed by the cAMP elevating agents, whereas TNF-alpha, IFN-gamma and IL-10 levels were unchanged. Intracellular cAMP levels are entirely hydrolyzed by cAMP-specific PDE 4 isozymes (PDE4s) in inflammatory and immunocompetent cells. Brucella reduced mRNA transcript levels for PDE4A by 40%, though PDE4B and 4D transcriptions were being unaffected in spleen. It was concluded that B. melitensis infection decreased activity of the antioxidant defence system, induced lipid peroxidation and suppressed PDE4A transcription. Administration of cAMP elevating agents exhibited similar affect with dexamethasone on lipid peroxidation, IL-12 production and antioxidant enzyme activities in Brucella infection. (C) 2007 Elsevier Ltd. All rights reserved.Öğe Effects of vitamin D3 and calcium on fracture healing in rats(Turkiye Klinikleri, 2006) Aslan, Bahadir; Kalaci, Aydmer; Bozlar, Murat; Atik, Esin; Yanat, Ahmet Nedim; Taşçi, ArzuObjective: We aimed in this study, to evaluate the effects and mechanism of action of single high-dose vitamin D3 and calcium on fracture healing in rats. Material and Methods: A total of 40 rats were divided into four groups; the first group (Group A) was treated with calcium, the second group (Group B) with vitamin D3, the third group (Group C) with calcium and vitamin D3 combination, and the fourth group was the control group (Group D). Tibiae of the rats were osteotomized by a Gigli saw. All rats were sacrificed 3 weeks after surgery. The results obtained were compared by mechanical testing, histological examination and radiographic evaluation. Results: Mean radiographic scores were 1.6 ± 0.8 for group D; 1.7 ± 0.8 for group A; 2.3 ± 0.8 for group B; and 2.4 ± 0.7 for group C. There was a statistically significant difference between the mean radiographic scores of only groups C and D (p = 0.037). There was also a statistically significant difference between the corresponding fracture load values of group D and all the other groups (p = 0.000), but there was no such difference between the corresponding fracture load values of the groups A and B (p = 0.208). Mean histological scores were 5.6 ± 2.7 for group D; 6.0 ± 2.7 for group A; 7.0 ± 2.1 for group B; and 7.2 ± 1.9 for group C (p> 0.05). Conclusion: These results suggested that the real effect of vitamin D on fracture healing was via calcium metabolism. We conclude that calcium and vitamin D given in the early stages of fracture healing gave opportunity for early weight bearing. Copyright © 2006 by Türkiye Klinikleri.Öğe Expression of cell proliferation markers in benign, premalignant and malignant lesions and human papillomavirus isolation(2007) Serarslan, Gamze; Atik, Esin; Otlu, Bariş; Bakariş, Sevgi; Durmaz, RizaBackground and Design: This study was designed to investigate the role of proliferation markers in various benign, premalignant and malignant skin lesions and also aimed to detect HPV positivity in these lesions. Material and Method: A total of 62 paraffin blocks [12 seborrheic keratoses (SK), 10 keratoacantoma (KA), 8 actinic keratoses (AK), 22 basal cell carcinoma (BCC), and 10 squamous cell carcinoma (SCC)] were included in the study. Specimens were studied immunohistochemically for the expression of Ki-67, p21 and bcl-2. PCR was performed to detect HPV DNA. Results: HPV positivity was detected in two tissues of BCC (HPV type-16). In the lesions, the Ki-67, p21 and bcl-2 expressions were found to be increased respectively: KAÖğe Expression of Cell Proliferation Markers in Benign, Premalignant and Malignant Lesions and Human Papillomavirus Isolation(Deri Zuhrevi Hastaliklar Dernegi, 2007) Serarslan, Gamze; Atik, Esin; Otlu, Baris; Bakaris, Sevgi; Durmaz, RizaBackground and Design: This study was designed to investigate the role of proliferation markers in various benign, premalig- nant and malignant skin lesions and also aimed to detect HPV positivity in these lesions. Material and Method: A total of 62 paraffin blocks [12 seborrheic keratoses (SK), 10 keratoacantoma (KA), 8 actinic keratoses (AK), 22 basal cell carcinoma (BCC), and 10 squamous cell carcinoma (SCC)] were included in the study. Specimens were stud- ied immunohistochemically for the expression of Ki-67, p21 and bcl-2. PCR was performed to detect HPV DNA. Results: HPV positivity was detected in two tissues of BCC (HPV type-16). In the lesions, the Ki-67, p21 and bcl-2 expressions were found to be increased respectively: KA
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