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  • Küçük Resim
    Öğe
    Effect of exogenous Melatonin administration on Spermatogenesis in chronic unpredictable stress rat model
    (Univ Zulia, Facultad Ciencias Veterinarias, 2023) Gokcek, Ishak; Aydin, Leyla; Cellat, Mustafa; Yavas, Ilker; Kutlu, Tuncer
    This study investigated the hormonal, inflammatory, oxidant-antioxidant, and histopathological effects of exogenous Melatonin administration on Spermatogenesis in rats' chronic unpredictable stress model (CUSM). In the study, stress caused a decrease in follicle stimulating-hormone (FSH), luteinizing hormone (LH), Testosterone, Melatonin, Glutathione (GSH), Glutathione peroxidase (GSH-Px), catalase, interleukin 10 (IL-10) levels and motility, and an increase in Corticosterone, nuclear factor kappa beta (NF-kB), tumor necrosis factor-alpha (TNF-alpha), interleukin 1 beta (IL-1 beta), interleukin 6 (IL-6), abnormal sperm, dead/live sperm ratio and exogenous Melatonin reduced inflammatory cytokines and oxidative stress and improved spermatological parameters (P<0.05). Melatonin also partially corrected stress-induced changes in testicular morphology. As a result, using Melatonin in rats with CUSM may be effective in improving spermatological parameters through anti-inflammatory and antioxidant mechanisms.
  • [ N/A ]
    Öğe
    Effect of Exogenous Melatonin Chronic Unpredictable Stress Model on Spermatogenesis in Rats
    (Wiley, 2022) Gokcek, Ishak; Aydin, Leyla; Cellat, Mustafa; Yavas, Ilker
    [Abstract Not Available]