Effect of exogenous Melatonin administration on Spermatogenesis in chronic unpredictable stress rat model
Yükleniyor...
Dosyalar
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Univ Zulia, Facultad Ciencias Veterinarias
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
This study investigated the hormonal, inflammatory, oxidant-antioxidant, and histopathological effects of exogenous Melatonin administration on Spermatogenesis in rats' chronic unpredictable stress model (CUSM). In the study, stress caused a decrease in follicle stimulating-hormone (FSH), luteinizing hormone (LH), Testosterone, Melatonin, Glutathione (GSH), Glutathione peroxidase (GSH-Px), catalase, interleukin 10 (IL-10) levels and motility, and an increase in Corticosterone, nuclear factor kappa beta (NF-kB), tumor necrosis factor-alpha (TNF-alpha), interleukin 1 beta (IL-1 beta), interleukin 6 (IL-6), abnormal sperm, dead/live sperm ratio and exogenous Melatonin reduced inflammatory cytokines and oxidative stress and improved spermatological parameters (P<0.05). Melatonin also partially corrected stress-induced changes in testicular morphology. As a result, using Melatonin in rats with CUSM may be effective in improving spermatological parameters through anti-inflammatory and antioxidant mechanisms.
Açıklama
Anahtar Kelimeler
Chronic stress, spermatogenesis, Melatonin, antioxidant, anti-inflammatory cytokines
Kaynak
Revista Cientifica-Facultad De Ciencias Veterinarias
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
33
Sayı
2
