Effect of exogenous Melatonin administration on Spermatogenesis in chronic unpredictable stress rat model

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dc.authoridGOKCEK, ISHAK/0000-0002-0590-6405
dc.contributor.authorGokcek, Ishak
dc.contributor.authorAydin, Leyla
dc.contributor.authorCellat, Mustafa
dc.contributor.authorYavas, Ilker
dc.contributor.authorKutlu, Tuncer
dc.date.accessioned2024-09-18T20:11:26Z
dc.date.available2024-09-18T20:11:26Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThis study investigated the hormonal, inflammatory, oxidant-antioxidant, and histopathological effects of exogenous Melatonin administration on Spermatogenesis in rats' chronic unpredictable stress model (CUSM). In the study, stress caused a decrease in follicle stimulating-hormone (FSH), luteinizing hormone (LH), Testosterone, Melatonin, Glutathione (GSH), Glutathione peroxidase (GSH-Px), catalase, interleukin 10 (IL-10) levels and motility, and an increase in Corticosterone, nuclear factor kappa beta (NF-kB), tumor necrosis factor-alpha (TNF-alpha), interleukin 1 beta (IL-1 beta), interleukin 6 (IL-6), abnormal sperm, dead/live sperm ratio and exogenous Melatonin reduced inflammatory cytokines and oxidative stress and improved spermatological parameters (P<0.05). Melatonin also partially corrected stress-induced changes in testicular morphology. As a result, using Melatonin in rats with CUSM may be effective in improving spermatological parameters through anti-inflammatory and antioxidant mechanisms.en_US
dc.identifier.doi10.52973/rcfcv-e33288
dc.identifier.issn0798-2259
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85172866496en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.52973/rcfcv-e33288
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8843
dc.identifier.volume33en_US
dc.identifier.wosWOS:001069703500027en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniv Zulia, Facultad Ciencias Veterinariasen_US
dc.relation.ispartofRevista Cientifica-Facultad De Ciencias Veterinariasen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronic stressen_US
dc.subjectspermatogenesisen_US
dc.subjectMelatoninen_US
dc.subjectantioxidanten_US
dc.subjectanti-inflammatory cytokinesen_US
dc.titleEffect of exogenous Melatonin administration on Spermatogenesis in chronic unpredictable stress rat modelen_US
dc.typeArticleen_US

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