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    SYNERGISTIC ACTIVITIES OF TWO PROPOLIS WITH AMPHOTERICIN B AGAINST SOME AZOLE-RESISTANT CANDIDA STRAINS. PART I
    (Incdtp-Icpi, 2010) Nizami, Duran; Mustafa, Muz; Gulbol, Duran Gulay; Burcin, Ozer; Yusuf, Onlen
    Propolis is a bee product which has many pharmacological properties and also used in traditional medicine. The objective of this work is to analyze and identify the components in propolis samples collected from the South-Eastern Mediterranean region of Anatolia (Hatay province) and South Marmara region (Bursa province) during 2007. The components of both propolis samples were identified by GS-MS analysis. The results of chemical composition show that aromatic acids, aromatic acid esters, flavanols, cinnamic acid esters have been found in two different propolis samples. Biologically active chemical constituents of propolis are highly variable, depending on the plant species, geographic area, and on the season of collection. The antifungal, antibacterial and antiviral properties of the studied samples were microbiologically analyzed for candida strains and the results are presented in the second part of this paper.
  • [ N/A ]
    Öğe
    Synergistic activities of two propolis with amphotericin B against some azole-resistant candida strains. Part I
    (2010) Nizami, Duran; Mustafa, Muz; Gulbol, Duran Gulay; Burcin, Ozer; Yusuf, Onlen
    Propolis is a bee product which has many pharmacological properties and also used in traditional medicine. The objective of this work is to analyze and identify the components in propolis samples collected from the South-Eastern Mediterranean region of Anatolia (Hatay province) and Souft Marmara region (Bursa province) during 2007. The components of both propolis samples were identified by GS-MS analysis. The results of chemical composition show that aromatic acids, aromatic acid esters, flavanols, cinnamic acid esters have been found in two different propolis samples. Biologically active chemical constituents of propolis are highly variable, depending on the plant species, geographic area, and on the season of collection. The antifungal, antibacterial and antiviral properties of the studied samples were microbiologically analyzed for Candida strains and the results are presented in the second part of this paper.
  • [ N/A ]
    Öğe
    SYNERGISTIC ACTIVITIES OF TWO PROPOLIS WITH AMPHOTERICIN B AGAINST SOME AZOLE-RESISTANT CANDIDA STRAINS. PART II
    (Incdtp-Icpi, 2010) Nizami, Duran; Mustafa, Muz; Gulbol, Duran Gulay; Burcin, Ozer; Yusuf, Onlen
    Candida strains are opportunistic pathogenic fungi in humans which can cause either septicaemic or mucosal infections. In this study, we aimed to investigate the existance of synergistic activities of two types of propolis (Hatay and Bursa) with Amphotericin B against some azole-resistant Candida strains. To evaluate cytotoxicity of propolis for human cells, the HEp-2 cell line (human larynx epidermoid carcinoma cell line) was used. The cytotoxicity of propolis samples was determined on a conventional haemocytometer using the trypan blue exclusion method. The synergystic activity of Hatay and Bursa propolis samples was assayed against four different azole-resistant Candida isolates (C. albicans, C. tropicalis, C. parapsilosis and C.glabrata). MIC values of Candida spp. were determined as described in the CLSI reference methods. The antifungal activities of a combination of this antifungal agent (Amphotericin B) were assessed by the checkerboard test and time-kill curve study. Bursa and Hatay propolis samples have remarkable antifungal activity against C.albicans, C.glabrata, C.tropicalis and C.parapsilosis. Also, the strong synergistic activity between Amphotericin B and propolis (especially Bursa propolis) was found against the azole resistant candida strains. Propolis may be an important prospect in the treatment of azole-resistant yeast. The effects of these two kinds of propolis against the Candida spp. in vitro are promising.
  • [ N/A ]
    Öğe
    Synergistic activities of two propolis with amphotericin B against some azole-resistant candida strains. Part II
    (2010) Nizami, Duran; Mustafa, Muz; Gulbol, Duran Gulay; Burcin, Ozer; Yusuf, Onlen
    Candida strains are opportunistic pathogenic fungi in humans which can cause either septicaemic or mucosal infections In this study, we aimed to investigate the existance of synergistic activities of two types of propolis (Hatay and Bursa) with Amphotericin B against some azole-resistant Candida strains. To evaluate cytotoxicity of propolis for human cells, the HEp-2 cell line (human larynx epidermoid carcinoma cell line) was used. The cytotoxicity of propolis samples was determined on a conventional haemocytometer using the trypan blue exclusion method. The synergystic activity of Hatay and Bursa propolis samples was assayed against four different azole-resistant Candida isolates (C. albicans, C. tropicalis, C. parapsilosis and C.glabrata). MIC values of Candida spp. were determined as described in the CLSI reference methods. The antifungal activities of a combination of this antifungal agent (Amphotericin B) were assessed by the checkerboard test and time-kill curve study. Bursa and Hatay propolis samples have remarkable antifungal activity against C.albicans, C.glabrata, C.tropicalis and C.parapsilosis. Also, the strong synergistic activity between Amphotericin B and propolis (especially Bursa propolis) was found against the azole resistant Candida strains. Propolis may be an important prospect in the treatment of azole-resistant yeast. The effects of these two kinds of propolis against the Candida spp. in vitro are promising.