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    Acquired lymphangioma circumscriptum of the vulva secondary to radiotherapy
    (Int Scientific Literature, Inc, 2010) Akansu, Bulent; Atik, Esin; Altintas, Suleyman; Serarslan, Gamze; Dolapcioglu, Kenan; Canda, M. Serefettin
    Background: Lymphangioma circumscriptum is a benign lesion of the lymphatics. The primary form of the disease is generally seen at birth or during childhood, whereas the secondary (acquired) form is a result of radiotherapy or a surgical procedure. Case Reoprt: A 38-year-old female patient was admitted to hospital with the complaint of skin eruptions on her vulva. About 10 years before she had had a total abdominal hysterectomy and bilateral salpingo-oophorectomy because of squamous cell carcinoma of the cervix and radiotherapy had been performed to the perineal region after surgery. Papillary-like lesions on the skin were seen in gross examination. These lesions were diagnosed as acquired lymphangioma circumscriptum by microscopy. Conclusions: Acquired lymphangioma is a benign lesion which can appear many years after radiotherapy. Several pre-malignant and malignant lesions can also occur following radiotherapy in this region. Therefore it is important for the clinician and pathologist to be aware of this situation and be careful when making the differential diagnosis.
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    Analysis of The Histopathological Changes of Epidural Space and Endoneural Structure in Lumbar Spinal Canal Stenosis: a Model For Chronic Compression of The Rat Cauda Equina
    (Journal Neurological Sciences, 2011) Ozdemir, Nail; Acar, Umit Dursun; Canda, M. Serefettin
    Objective: The purpose of study was to produce chronic cauda equina compression in rats for analysis of the histopathologic changes of two different group. Method: Twenty-one adult male Wistar rats were studied. A single-lumen polyurethane catheter was used. Seven rats, the sham-operated group, had laminectomy only. The spinal canal was obstructed 25% in seven rats, 65% in another seven. Obstruction area of the group that was obstructed 25% and 65%, proximal and distal region of this area and laminectomy area of the sham-operated group of which only laminectomy was applied were examined even in epidural space and endoneural structures histopathologically. In consideration of information that were obtained from examinations; hemorrhage, inflammation, fibroblast proliferation, capillary proliferation in epidural space; nerve fiber damage, edema, inflammation and hemorrhage parameters in endoneural structures were evaluated by mild, moderate and severe categories. Results: No nerve fiber damage was present in laminectomy area and its proximal and distal of the sham-operated group. All samples from the obstruction area in the 25% and 65% obstructed groups showed nerve fiber damage. Nerve fiber damage was observed both proximal and distal area of all sections in 65% obstructed group. Conclusions: Neurological deficit was observed only in 65% group. Impression degree seems to be important in formation of neurological parameter. Changes in nerve fiber structure are observed in slight obstructions. These changes characterized with vacuolization are observed more frequent when the obstruction increases. Also, distal and proximal area of this impression area is effected in severe lumbar stenosis.
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    Massive Edema of the Ovary: Case Report
    (De Gruyter Open Ltd, 2010) Akansu, Bulent; Atik, Esin; Altintas, Suleyman; Gungoren, Arif; Canda, M. Serefettin
    Massive ovarian edema is a rare condition characterized by marked enlargement of one or both ovaries as a result of accumulation of edema fluid in stroma. It is a benign lesion and is generally seen in young females between 6-33 years of age. Our aim is to remind that massive ovarian edema should be considered in the differential diagnosis especially in young patients to avoid aggressive treatment. Our patient was a 17-year-old female who was admitted to our hospital with complaints of irregular menstruation and right groin pain for the last 3 months. There was no remarkable finding in the physical examination. 'Sex-cord stromal tumor (luteinized thecoma)' could not be excluded in the intraoperative frozen section. The diagnosis was reported as 'massive ovarian edema' with routine examination. Pathological evaluation is required because of the difficulty of differentiating these lesions from malignant lesions with radiological methods in the pre-operative period. Although it is a rare lesion, clinicians and pathologists should consider it in the differential diagnosis to avoid aggressive treatment.