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    Effect of domoic acid on growth and heavy metal tolerance of some marine bacteria isolated from Samandag shore and Iskenderun bay
    (Journal of Pure and Applied Microbiology, 2014) Coral, M. Nisa Unaldi; Yildirim, Aydil
    In the current study, effects of domoic acid on some marine bacteria were studied. Domoic acid is a neurotoxin which affects human and animals and by some marine microalgea. For this study, heterotrophic marine bacteria were isolated from Iskenderun Bay and Samandag shore. 19 Pseudomonas sp. strains, 15 Acinetobacter sp. strains, 5 Alteromonas sp. strains and 9 Vibrio sp. strains were identified. For inhibition tests, varing concentrations of domoic acid (0.5?gr.ml-1 and 1 mgr.ml-1) were tested. It was found that there is not any inhibition effect of domoic acid on the all bacteria with used concentrations. Stimulator effect was determined by getting growth curve from the bacteria cultures which was added varying concentrations of domoic acid. It was found that 2.5 ?gr.ml-1 and 5 ?gr.ml-1 domoic acid showed inducer effect on 1.6 Pseudomonas sp. strain and 4.4 Vibrio sp. strain growth. In this study, it was also investigated the effect of domoic acid on heavy metal tolerance of these bacteria. The results of these study will contribute novel information on the effect of domoic acid on marine bacteria.
  • Küçük Resim
    Öğe
    Potential neoplastic effects of parathion-methyl on rat liver
    (Science Press, 2009) Coral, M. Nisa Unaldi; Ucman, Sonay; Yildiz, Hasan; Oztas, Haydar; Dalkilic, Semih
    The mutagenic and carcinogenic effects of parathion-methyl were examined by bacterial reverse mutation assay and a long-term experiment with wistar rats. The potential mutagenic effect of parathion-methyl in Salmonella typhimurium TA100 bacterial cells was observed without rat liver S9 metabolic activation. Parathion-methyl was further investigated for pathological changes in rat pancreas and liver. The long-term rat experiments showed that parathion-methyl exposure for 3 months can cause pathological changes in rat pancreases acinar cells and pancreatic hepatocytes. Atypical acinar cell focuses (AACF) were determined in the liver and pancreas of the rats. The results from short-term Ames test and long-term rat experiments suggested that parathion-methyl would be potential carcinogenic.