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    Protective effect of dexpanthenol on gentamicin-induced nephrotoxicity in rats
    (İnönü Üniversitesi, 2019) Pınar, Neslihan; Özcan, Oğuzhan; Doğan, Esin; Çakırca, Gökhan
    Aim: We evaluated the protective effects of dexpanthenol (Dxp) in rats with gentamicin (Genta)-induced nephrotoxicity by assessing a panel of biochemical and histopathologic parameters. Material Methods: Forty rats were divided randomly into the following four groups: Control group, physiological saline solution (0.5 cc intraperitoneally (i.p.) for 8 days; Dxp group, Dxp (500 mg/kg i.p.) for 8 days; Genta group, Genta (100 mg/kg, i.p.) for 8 days; and Genta+Dxp group, Gent a and Dxp (100 and 500 mg/kg i.p., respectively) for 8 days. Results: TIn the Genta group, the urea, creatinine, tumor necrosis factor-alpha (TNF-α), total oxidant status (TOS), oxidative stress index (OSI) and malondialdehyde (MDA) levels were significantly higher and the catalase (CAT) and glutathione peroxidase (GSH-Px) activities were significantly lower than those in the control group. In the Genta+Dxp group, the urea, creatinine, and TNF-α, TOS, OSI and MDA levels were significantly lower and the CAT and GSH-Px activities were significantly higher than those in the Genta group. Histopathological investigation showed severe tubular necrosis in the Genta group, which was of lesser severity in the Genta+Dxp group. Conclusion: The biochemical and histopathologic results of this study indicate that Dxp can ameliorate Genta-induced nephrotoxicity
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    Rhabdomyosarcoma in the Oral Cavity of A Pediatric Patient: A Rare Case
    (2023) Şimşek, Betül; Doğan, Esin; Kuzuluk, Didar Gürsoy; Cemaloğlu, Mustafa
    Dear Editor, Rhabdomyosarcoma (RMS) is a rare, aggressive, and malignant neoplasm with rapid growth composed of primitive mesenchymal cells that exhibit skeletal muscle differentiation and mainly affects children and adolescents (60%) [1]. RMS is the most common soft tissue sarcoma with a rate of 50-60% in pediatric patients and ranks third among pediatric extracranial solid tumors, following Wilms tumor and neuroblastoma at a rate of 4-5% [2]. Head and neck localizations constitute 35–40% of cases, with oral lesions being extremely rare [3].