Protective effect of dexpanthenol on gentamicin-induced nephrotoxicity in rats
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Date
2019
Journal Title
Journal ISSN
Volume Title
Publisher
İnönü Üniversitesi
Access Rights
info:eu-repo/semantics/openAccess
Abstract
Aim: We evaluated the protective effects of dexpanthenol (Dxp) in rats with gentamicin (Genta)-induced nephrotoxicity by assessing a panel of biochemical and histopathologic parameters.
Material Methods: Forty rats were divided randomly into the following four groups: Control group, physiological saline solution (0.5 cc intraperitoneally (i.p.) for 8 days; Dxp group, Dxp (500 mg/kg i.p.) for 8 days; Genta group, Genta (100 mg/kg, i.p.) for 8 days; and Genta+Dxp group, Gent a and Dxp (100 and 500 mg/kg i.p., respectively) for 8 days.
Results: TIn the Genta group, the urea, creatinine, tumor necrosis factor-alpha (TNF-α), total oxidant status (TOS), oxidative stress index (OSI) and malondialdehyde (MDA) levels were significantly higher and the catalase (CAT) and glutathione peroxidase (GSH-Px) activities were significantly lower than those in the control group. In the Genta+Dxp group, the urea, creatinine, and TNF-α, TOS, OSI
and MDA levels were significantly lower and the CAT and GSH-Px activities were significantly higher than those in the Genta group. Histopathological investigation showed severe tubular necrosis in the Genta group, which was of lesser severity in the Genta+Dxp group.
Conclusion: The biochemical and histopathologic results of this study indicate that Dxp can ameliorate Genta-induced nephrotoxicity
Description
Keywords
Oxidative stress, Antioxidant, Gentamicin, Nephrotoxicity, Dexpanthenol
Journal or Series
Annals of Medical Research
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Volume
26
Issue
9
Citation
Pinar, N., Ozcan, O., Dogan, E., & Cakirca, G. (2019). Protective effect of dexpanthenol on gentamicin-induced nephrotoxicity in rats. Annals of Medical Research, 26(9), 1787-91.
