Protective effect of dexpanthenol on gentamicin-induced nephrotoxicity in rats

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dc.authorid0000-0001-5863-9665en_US
dc.authorid0000-0003-1526-5899en_US
dc.contributor.authorPınar, Neslihan
dc.contributor.authorÖzcan, Oğuzhan
dc.contributor.authorDoğan, Esin
dc.contributor.authorÇakırca, Gökhan
dc.date.accessioned2020-07-23T11:22:04Z
dc.date.available2020-07-23T11:22:04Z
dc.date.issued2019en_US
dc.departmentTayfur Ata Sökmen Tıp Fakültesien_US
dc.description.abstractAim: We evaluated the protective effects of dexpanthenol (Dxp) in rats with gentamicin (Genta)-induced nephrotoxicity by assessing a panel of biochemical and histopathologic parameters. Material Methods: Forty rats were divided randomly into the following four groups: Control group, physiological saline solution (0.5 cc intraperitoneally (i.p.) for 8 days; Dxp group, Dxp (500 mg/kg i.p.) for 8 days; Genta group, Genta (100 mg/kg, i.p.) for 8 days; and Genta+Dxp group, Gent a and Dxp (100 and 500 mg/kg i.p., respectively) for 8 days. Results: TIn the Genta group, the urea, creatinine, tumor necrosis factor-alpha (TNF-α), total oxidant status (TOS), oxidative stress index (OSI) and malondialdehyde (MDA) levels were significantly higher and the catalase (CAT) and glutathione peroxidase (GSH-Px) activities were significantly lower than those in the control group. In the Genta+Dxp group, the urea, creatinine, and TNF-α, TOS, OSI and MDA levels were significantly lower and the CAT and GSH-Px activities were significantly higher than those in the Genta group. Histopathological investigation showed severe tubular necrosis in the Genta group, which was of lesser severity in the Genta+Dxp group. Conclusion: The biochemical and histopathologic results of this study indicate that Dxp can ameliorate Genta-induced nephrotoxicityen_US
dc.identifier.citationPinar, N., Ozcan, O., Dogan, E., & Cakirca, G. (2019). Protective effect of dexpanthenol on gentamicin-induced nephrotoxicity in rats. Annals of Medical Research, 26(9), 1787-91.en_US
dc.identifier.doi10.5455/annalsmedres.2019.07.435en_US
dc.identifier.endpage1791en_US
dc.identifier.issn2636-7688
dc.identifier.issue9en_US
dc.identifier.startpage1787en_US
dc.identifier.trdizinid318146en_US
dc.identifier.urihttps://dx.doi.org/10.5455/annalsmedres.2019.07.435
dc.identifier.urihttps://hdl.handle.net/20.500.12483/2925
dc.identifier.volume26en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherİnönü Üniversitesien_US
dc.relation.ispartofAnnals of Medical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/
dc.subjectOxidative stressen_US
dc.subjectAntioxidanten_US
dc.subjectGentamicinen_US
dc.subjectNephrotoxicityen_US
dc.subjectDexpanthenolen_US
dc.titleProtective effect of dexpanthenol on gentamicin-induced nephrotoxicity in ratsen_US
dc.typeArticleen_US

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