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Öğe COVID-19 hastalarında çinko düzeylerinin incelenmesi(2022) Doğan, Serdar; Bal, TayibeAmaç: Çinko (Zn), immün yanıtı güçlendirici etkisinin yanı sıra viral enfeksiyonlara karşı savunmada da rol oynadığı bilinen önemli bir eser elementtir. Bu çalışma ile kliniğimizde izlenen COVID-19 olgularında Zn düzeylerinin belirlenerek, rutin laboratuvar parametreleri ve hastalık şiddeti ile olan ilişkisinin irdelenmesi amaçlanmıştır.\rYöntem: Çalışmaya 135 COVID-19 hastası ile 26 sağlıklı birey dahil edilmiştir. Serum Zn, düzeyleri kolorimetrik yöntem ile ölçülmüştür. Ayrıca kreatinin, ALT, AST CK, LDH, ferritin, CRP, D-dimer ve fibrinojen düzeyleri değerlendirilmiştir.\rBulgular: Serum Zn düzeyleri tüm hasta gruplarında kontrol grubuna kıyasla; orta, ağır ve kritik hasta gruplarında ise hafif hasta grubuna kıyasla istatistiksel olarak anlamlı düzeyde düşük bulunmuştur. Ayrıca Zn düzeyleri kreatinin, ALT, AST, CK, lökosit düzeyleri ile zayıf negatif ve anlamlı bir korelasyon gösterirken, yaş, CRP, ferritin, D-dimer ve fibrinojen düzeyleri ile anlamlı, orta derecede ve negatif yönde bir korelasyon göstermiştir.\rSonuç: Serum Zn düzeyleri COVID-19 hastalarında sağlıklı bireylere göre istatistiksel olarak anlamlı oranda daha düşüktür. COVID-19 olgularında hastalık şiddeti ile serum Zn düzeyleri arasında net bir ilişki bulunamamış olsa da hastalık şiddeti ile ilişkili biyokimyasal ve inflamatuar markırlar ile serum Zn düzeyleri arasında anlamlı bir ilişki olduğu görülmüştür.Öğe Determination of 25 hydroxyvitamin D reference ranges in Hatay region by indirect method(2023) Oğuzman, Hamdi; Doğan, SerdarObjective: The aim of this study is to determine the reference ranges of 25 hydroxyvitamin D (25(OH)D) levels from the serum 25(OH)D results of the patients and to investigate variations across age and gender groups. Methods: The patients (n=26829) who applied to Hatay Mustafa Kemal University Hospital between January 2018 and December 2019 and whose 25(OH)D levels were studied were included in this retrospective study. Serum 25(OH)D levels were studied by the chemiluminescence immunoassay method. The hospital information management system was used to obtain the test results and patient data. The indirect method was used to determine the reference ranges. Results: The prevalence of 25(OH)D deficiency in the patients participating in this study was 60.9% in the general population, 54.9% in men, and 67.5% in women. It has been observed that 25(OH)D deficiency is more common in women than in men. The reference ranges determined in this study were lower than the reference ranges provided by the manufacturer. Conclusion: In this study, 25(OH)D levels and reference ranges of Hatay Region were determined in a very large population. It can be said that the results of our region will contribute to the studies to be carried out on the determination of 25(OH)D levels and reference ranges throughout the country.Öğe Diyabet Hastalarında Hematüri Sıklığı ve Albüminüri ile İlişkisi(2022) Yılmaz, Müge Özsan; Doğan, Serdar; Turgut, Faruk HilmiAmaç: Bu çalışmanın amacı diyabetik hastalarda hematüri sıklığını belirlemek ve bunun mevcut klinik ve laboratuvar değişkenleriyle özellikle de\ralbüminüri ile olan ilişkisini değerlendirmektir.\rYöntem: Çalışmaya aynı başvuruda tam idrar tahlili ve idrar albümin/kreatinin oranı istenen 302 diyabet hastası dahil edilmiştir. Hastalar hematürisi\rolan ve hematürisi olmayan hastalar şeklinde iki gruba ayrılmıştır. Hastalara ait hemogram sonuçları, spot idrar albümin ve kreatinin düzeyleri, serum\rglukoz, total kolesterol, LDL kolesterol, trigliserid, BUN, kreatinin, albumin, sodyum ve potasyum sonuçlarıyla ALT ve AST enzim aktiviteleri, tam idrar\rtahlili, serum CRP düzeyleri, HbA1c düzeyleri ve tahmini glomerüler filtrasyon hızı (eGFR) düzeyleri retrospektif olarak değerlendirilmiştir.\rBulgular: Çalışmaya dahil edilen hastaların yaş ortalaması 54±13 yıl bulunmuştur. Hastaların %23.5 (n=71)’inde hematüri saptanmıştır. Çalışmaya dahil\redilen 229 (%75.8) hastanın normoalbüminürik, 52 (%17.2) hastanın mikroalbüminürik, 21 (%7) hastanın ise makroalbuminürik olduğu görülmüştür.\rHematürisi olan diyabetik hastaların idrar albüminüri değerleri hematürisi olmayanlara göre istatistiksel olarak anlamlı şekilde yüksek saptandı (14.23\rmg/g vs 1.96 mg/g, p<0.001). Makroalbüminüri görülme oranı hematürisi olan hastalarda olmayanlara göre istatistiksel olarak anlamlı şekilde yüksek\rbulunmuştur. Hematürisi olan hastaların ortalama eGFR değerleri hematürisi olmayan hastalar ile karşılaştırıldığında daha düşük bulunmuştur. Ancak\ristatiksel anlamlılığa ulaşmamıştır (p=0.055).\rSonuç: Diyabetik hastalarda hematüri sık görülmektedir ve hematüri diyabetik böbrek hastalığının bir bulgusu olarak karşımıza çıkabilir. Hematürisi\rolan hastalarda albüminüri değerleri daha yüksek ve eGFR değerleri daha düşük bulunmuştur.Öğe Intra-day changes in the levels of biochemistry parameters(2022) Arpacı, Abdullah; Doğan, Serdar; Gül, Bahar Ünlü; Kuş, Berna; Dırıcan, EmreObjectives: People mostly live in the nonfasting state during a normal 24-h cycle. This study aims to compare the levels of\r18 biochemical parameters during different hours of the day.\rMethods: A total of 18 biochemical tests of patients who visited outpatient clinics only once between January 1, 2010,\rand December 31, 2019, were evaluated at the Hatay Mustafa Kemal University (HMKU) Central Laboratory by using\rhospital database information. The tests are albumin (Alb), aspartate aminotransaminase (AST), alanine aminotransaminase\r(ALT), alkaline phosphatase (ALP), amylase, blood urea nitrogen (BUN), calcium (Ca), total cholesterol (TC), creatine\rkinase (CK), creatinine (Cr), gamma-glutamyltransferase (GGT), glucose, high-density lipoprotein cholesterol\r(HDL-C), inorganic phosphorus (Pi), iron (Fe), total protein (TP), triglyceride (TG), and lipase. The blood samples of the\rpatient were divided into eight groups according to their collection time as follows: (a) 07:00-07:59, (b) 08:00-08:59, (c)\r09:00-09:59, (d) 10:00-10:59, (e) 11:00-11:59, (f ) 12:00-13:59, (g) 14:00-14:59, and (h) 15:00-17:00.\rResults: A statistically significant difference was found between the groups in terms of all parameters except amylase,\rGGT, and TP (p<0.05). The effect size refers to the minimum amount of difference that is clinically significant. According\rto the effect size values, there was no significant difference between time groups in the following parameters: Alb, ALT,\rAST, Pi, Ca, TC, Cr, Fe, glucose, BUN, lipase, TG, ALP, HDL-C, and CK (?<0.30).\rConclusion: When considering all of the results, nonfasting screening would not only be acceptable but also make\rphysiologic sense.Öğe Monocyte eosinophil ratio and red blood cell distribution width in the diagnosis of asthma(2023) Koç, İbrahim; Doğan, SerdarObjective: Bronchial asthma is often associated with chronic airway inflammation and airway hyperresponsiveness in which many cells and mediators are involved. Pulmonary function tests (PFTs) are used in the diagnosis of the disease. Yet PFTs are not available in every healthcare institution or some of the patients cannot cooperate with the procedure. The aim of this study was to determine whether mean platelet volume (MPV), platelet distribution width (PDW), monocyte lymphocyte ratio (MLR), monocyte eosinophil ratio (MER), and platelet lymphocyte ratio (PLR) can be used in the diagnosis of bronchial asthma. Method: Two hundred and twelve patients who were diagnosed with bronchial asthma according to the Global Initiative for Asthma (GINA) criteria and 187 patients who were deemed not to have asthma were included in the study. Two patient groups were compared by examining the hemogram parameters at the time of diagnosis or exclusion of asthma. Results: The levels of MPV, neutrophil-lymphocyte ratio (NLR), and PLR were significantly lower in the Asthma group (pÖğe ORAL PRESENTATION ABSTRACTS(De Gruyter Open Ltd, 2024) Özcan, Oğuzhan; Doğan, Serdar; Çiçek, Güner; Kaçmaz, Filiz; Oğuzman, Hamdi; Arpacı, AbdullahObjectives: This study investigated the effect of aerobic exercise on serum irisin, preptin levels in overweight women and their relationship with routine biochemical tests. Methods: The study included 25 healthy controls and 25 overweight sedentary women (BMI>25). The exercise training was performed 3 days a week for 12 weeks. Anthropometric measurements were performed and fasting blood samples were collected before and after exercise period. All samples were centrifuged at 1500xg for 10 minutes and the serum was separated. Serum irisine and preptin levels were analyzed by ELISA method. Routine biochemical parameters were assayed by spectrophotometric, hsCRP levels by nephelometric and insulin levels by immunoassay method using auto analyzers. Results: There was a significant decrease in BMI and fat mass in the post-exercise group compared with pre-exercise (p<0.001). Serum irisin levels were significantly lower in pre- and post-exercise group compared to controls (p<0.001), but no significant change was observed after exercise period. Preptin levels were significantly higher in the pre-exercise group (median/IQR, 558.2 /351,2-756,8 pg/ml) compared to the controls (median / IQR, 137.1/85.2-427.9 pg/ ml), and significantly reduced in post-exercise group (medium/IQR, 243.1/179.2-330 pg/ml) compared to pre-exercise group. In the pre-exercise group, a significant negative correlation was observed between irisin and body mass index (r=-0.443, p=0,027), while a positive correlation was found between preptin and body weight (r=0.438, p=0.029). Conclusions: Twelve weeks of aerobic exercise in overweight sedentary women has lowering effect on serum preptin levels but no effect on serum irisin levels. © 2024 De Gruyter Open Ltd. All rights reserved.Öğe Relationship of Semaphorin Proteins with Blood Markers in Patients with COVID-19(2023) Okuyan, Hamza Malik; Doğan, Serdar; Bal, Tayibe; Çabalak, MehmetAim: The COVID outbreak is a serious health problem affecting socio-economic life and healthcare systems worldwide. Although the role of Semaphorins in some diseases is relatively known, the association of these molecules with the pathogenesis of COVID-19 remains unclear. Therefore, we aimed to investigate the relationship of Semaphorins (Sema3A, Sema4A, Sema4D and Sema7A) with biochemical and inflammatory alterations and their roles in predicting the presence of disease and disease severity in COVID-19 patients. Material and Method: A total of 144 COVID-19 patients and 20 healthy individuals were enrolled in the current study. Serum Semaphorins were analyzed using Enzyme-linked Immunosorbent Assay. Other laboratory parameters were measured using routine laboratory techniques. Results: Sema3A concentrations were elevated in both patients with severe and non-severe COVID-19 groups compared with healthy controls (p<0.0001). Sema4A levels were significantly decreased in patients with the severe COVID-19 group (p=0.002). Sema3A was negatively correlated with routine hematological markers such as EOS, RBC, HGB, HCT and MCV. Further, Sema3A was positively correlated with coagulation markers such as D-dimer and fibrinogen and the inflammatory markers, such as ESR, CRP, PCT and ferritin and biochemical markers such as ALT, AST, BUN, CK and LDH. Sema4A was negatively correlated with WBC, while it was positively correlated with LYM and HCT. Sema3A levels over 3.03 ng/mL and Sema4A concentrations of less than 11.8 ng/mL may predict the presence of COVID-19 (p<0.0001, p=0.02, respectively). Conclusion: Our data presented here suggest that Sema3A and Sema4A could be diagnostic markers for COVID-19 and may have importance in the clinical management of the disease.