Intra-day changes in the levels of biochemistry parameters
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Tarih
2022
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objectives: People mostly live in the nonfasting state during a normal 24-h cycle. This study aims to compare the levels of\r18 biochemical parameters during different hours of the day.\rMethods: A total of 18 biochemical tests of patients who visited outpatient clinics only once between January 1, 2010,\rand December 31, 2019, were evaluated at the Hatay Mustafa Kemal University (HMKU) Central Laboratory by using\rhospital database information. The tests are albumin (Alb), aspartate aminotransaminase (AST), alanine aminotransaminase\r(ALT), alkaline phosphatase (ALP), amylase, blood urea nitrogen (BUN), calcium (Ca), total cholesterol (TC), creatine\rkinase (CK), creatinine (Cr), gamma-glutamyltransferase (GGT), glucose, high-density lipoprotein cholesterol\r(HDL-C), inorganic phosphorus (Pi), iron (Fe), total protein (TP), triglyceride (TG), and lipase. The blood samples of the\rpatient were divided into eight groups according to their collection time as follows: (a) 07:00-07:59, (b) 08:00-08:59, (c)\r09:00-09:59, (d) 10:00-10:59, (e) 11:00-11:59, (f ) 12:00-13:59, (g) 14:00-14:59, and (h) 15:00-17:00.\rResults: A statistically significant difference was found between the groups in terms of all parameters except amylase,\rGGT, and TP (p<0.05). The effect size refers to the minimum amount of difference that is clinically significant. According\rto the effect size values, there was no significant difference between time groups in the following parameters: Alb, ALT,\rAST, Pi, Ca, TC, Cr, Fe, glucose, BUN, lipase, TG, ALP, HDL-C, and CK (?<0.30).\rConclusion: When considering all of the results, nonfasting screening would not only be acceptable but also make\rphysiologic sense.
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Kaynak
International Journal of Medical Biochemistry
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Scopus Q Değeri
Cilt
5
Sayı
2
