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    Protective Effect of Colchicine on Ovarian Ischemia-Reperfusion Injury: An Experimental Study
    (Springer Heidelberg, 2015) Kurt, Raziye Keskin; Dogan, Ayse Citil; Dogan, Murat; Albayrak, Aynur; Kurt, Sefika Nur; Eren, Furkan; Okyay, Ayse Guler
    Objective: The aim of the present study is to investigate the efficiency of colchicine in the experimental rat ovarian torsion model in the light of histological and biochemical data. Study Design: A total of 35 Wistar albino female rats were randomly divided into 5 groups, group 1: (control-sham operated, n = 7); group 2: (torsion/detorsion, n = 7) 2 hours of ischemia and 2 hours of reperfusion; group 3: (torsion/detorsion, n = 7), 2 hours of ischemia and 5 days of reperfusion; group 4: (torsion/detorsion, n = 7) 2 hours of ischemia and 2 hours of reperfusion and a signal dose of oral 1 mL/kg colchicine; and group 5: (torsion/detorsion, n = 7), 2 hours of ischemia and 5 days of reperfusion and 5 days of oral 1 mg/kg colchicine. Histopathologic evaluation was performed by a scoring that assesses congestion, bleeding, edema, and cellular degeneration in the ovarian tissue. Catalase, tissue malondialdehyde (MDA), and protein carbonyl levels were calculated. Results: The histopathologic scores, MDA, and protein carbonyl levels in the control and colchicine groups were significantly lower than groups 2 and 3 (P < .001). Catalase activities were significantly higher in the control and colchicine groups than in groups 2 and 3 (P < .001). The results of the histopathologic parameters and biochemical markers showed that protective effects of colchicine treatment persisted up to 5 days. Conclusion: Our study results revealed that colchicine reduced ovarian ischemia-reperfusion injury in experimental rat ovarian torsion model. As the ovarian detorsion is the first choice of the treatment modality in the early phase, antioxidant and anti-inflammatory treatment modalities like colchicine might be used to reduce ovarian ischemia-reperfusion injury.
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    Zofenopril attenuates injury induced by ischemia-reperfusion on rat ovary
    (Wiley, 2015) Kurt, Raziye Keskin; Dogan, Ayse Citil; Dogan, Murat; Albayrak, Aynur; Kurt, Sefika Nur; Eren, Furkan; Silfeler, Dilek Benk
    AimThe aim of the study was to investigate the effectiveness of zofenopril in an experimental model of ovarian torsion in rats with histologic and biochemical assessments. Material and MethodsExperimental procedures were performed on 35 female rats (Wistar albino). Rats were randomly divided into five groups as: sham (sham operated, n=7); vehicle group 1 (torsion-detorsion, n=7) with 2h ischemia and 2h reperfusion; vehicle group 2 (torsion-detorsion, n=7) with 2h ischemia and 5 days' reperfusion; zofenopril group 1 (torsion-detorsion, n=7) with 2h ischemia, 2h reperfusion and a signal dose of oral 15mg/kg zofenopril; and zofenopril group 2 (torsion-detorsion, n=7) with 2h ischemia, 5 days' reperfusion and 5 days' oral 15mg/kg zofenopril. A scoring of histopathologic evaluation was performed on the ovaries according to congestion, bleeding, edema, and cellular degeneration. Biochemical assessments included catalase, tissue malondialdehyde and protein carbonyl. ResultsCompared with the vehicle groups, histopathologic scores, tissue malondialdehyde and protein carbonyl levels, which reflect oxidative stress markers, were significantly lower in the zofenopril groups. Furthermore, catalase levels were significantly increased in the zofenopril group. ConclusionOur study results revealed that zofenopril attenuates injury induced by ischemia-reperfusion on rat ovary.