Zofenopril attenuates injury induced by ischemia-reperfusion on rat ovary
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Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
AimThe aim of the study was to investigate the effectiveness of zofenopril in an experimental model of ovarian torsion in rats with histologic and biochemical assessments. Material and MethodsExperimental procedures were performed on 35 female rats (Wistar albino). Rats were randomly divided into five groups as: sham (sham operated, n=7); vehicle group 1 (torsion-detorsion, n=7) with 2h ischemia and 2h reperfusion; vehicle group 2 (torsion-detorsion, n=7) with 2h ischemia and 5 days' reperfusion; zofenopril group 1 (torsion-detorsion, n=7) with 2h ischemia, 2h reperfusion and a signal dose of oral 15mg/kg zofenopril; and zofenopril group 2 (torsion-detorsion, n=7) with 2h ischemia, 5 days' reperfusion and 5 days' oral 15mg/kg zofenopril. A scoring of histopathologic evaluation was performed on the ovaries according to congestion, bleeding, edema, and cellular degeneration. Biochemical assessments included catalase, tissue malondialdehyde and protein carbonyl. ResultsCompared with the vehicle groups, histopathologic scores, tissue malondialdehyde and protein carbonyl levels, which reflect oxidative stress markers, were significantly lower in the zofenopril groups. Furthermore, catalase levels were significantly increased in the zofenopril group. ConclusionOur study results revealed that zofenopril attenuates injury induced by ischemia-reperfusion on rat ovary.
Description
Keywords
antioxidant, ischemia-reperfusion injury, ovarian torsion, zofenopril
Journal or Series
Journal of Obstetrics and Gynaecology Research
WoS Q Value
Q4
Scopus Q Value
Q2
Volume
41
Issue
6
