Zofenopril attenuates injury induced by ischemia-reperfusion on rat ovary

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dc.authoridDelibasi, Tuncay/0000-0002-5780-8209
dc.authoridbenk silfeler, dilek/0000-0002-3533-0523
dc.authoridDogan, Murat/0000-0003-0002-8428
dc.contributor.authorKurt, Raziye Keskin
dc.contributor.authorDogan, Ayse Citil
dc.contributor.authorDogan, Murat
dc.contributor.authorAlbayrak, Aynur
dc.contributor.authorKurt, Sefika Nur
dc.contributor.authorEren, Furkan
dc.contributor.authorSilfeler, Dilek Benk
dc.date.accessioned2024-09-18T19:54:37Z
dc.date.available2024-09-18T19:54:37Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAimThe aim of the study was to investigate the effectiveness of zofenopril in an experimental model of ovarian torsion in rats with histologic and biochemical assessments. Material and MethodsExperimental procedures were performed on 35 female rats (Wistar albino). Rats were randomly divided into five groups as: sham (sham operated, n=7); vehicle group 1 (torsion-detorsion, n=7) with 2h ischemia and 2h reperfusion; vehicle group 2 (torsion-detorsion, n=7) with 2h ischemia and 5 days' reperfusion; zofenopril group 1 (torsion-detorsion, n=7) with 2h ischemia, 2h reperfusion and a signal dose of oral 15mg/kg zofenopril; and zofenopril group 2 (torsion-detorsion, n=7) with 2h ischemia, 5 days' reperfusion and 5 days' oral 15mg/kg zofenopril. A scoring of histopathologic evaluation was performed on the ovaries according to congestion, bleeding, edema, and cellular degeneration. Biochemical assessments included catalase, tissue malondialdehyde and protein carbonyl. ResultsCompared with the vehicle groups, histopathologic scores, tissue malondialdehyde and protein carbonyl levels, which reflect oxidative stress markers, were significantly lower in the zofenopril groups. Furthermore, catalase levels were significantly increased in the zofenopril group. ConclusionOur study results revealed that zofenopril attenuates injury induced by ischemia-reperfusion on rat ovary.en_US
dc.description.sponsorshipTurkish Academy of Science (TUBA)en_US
dc.description.sponsorshipErsin Fadillioglu and Tuncay Delibasi were partly supported by The Turkish Academy of Science (TUBA).en_US
dc.identifier.doi10.1111/jog.12658
dc.identifier.endpage931en_US
dc.identifier.issn1341-8076
dc.identifier.issn1447-0756
dc.identifier.issue6en_US
dc.identifier.pmid25546378en_US
dc.identifier.scopus2-s2.0-84930335022en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage926en_US
dc.identifier.urihttps://doi.org/10.1111/jog.12658
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7830
dc.identifier.volume41en_US
dc.identifier.wosWOS:000355743000014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Obstetrics and Gynaecology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantioxidanten_US
dc.subjectischemia-reperfusion injuryen_US
dc.subjectovarian torsionen_US
dc.subjectzofenoprilen_US
dc.titleZofenopril attenuates injury induced by ischemia-reperfusion on rat ovaryen_US
dc.typeArticleen_US

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