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Öğe Assessment of Ischemia Modified Albumin as a Marker of Oxidative Stress in Chronic Kidney Disease(Wolters Kluwer Medknow Publications, 2021) Ozkurt, Sultan; Ozcan, Oguzhan; Dogan, IbrahimIncreased oxidative stress (OS) in chronic kidney disease (CKD), and particularly in those undergoing hemodialysis (HD), is widely recognized. We aimed to evaluate ischemia modified albumin (IMA) as a marker of OS in CKD patients who are not yet on HD compared to chronic HD patients. A cross-sectional study was conducted in Hitit University, Corum, Turkey in 2015. In this study, 39 chronic HD and 36 CKD patients in stage 3-4 were included, as well as 34 healthy individuals as a control group. IMA levels in HD patients (before and after HD session), stage 3-4 CKD patients and control group were evaluated using the ELISA method. Pre-HD and post-HD albumin levels were measured and albumin-adjusted IMA (aIMA) levels were calculated. IMA and aIMA levels were higher in chronic HD and CKD patients who are not yet on HD, compared to healthy individuals (IMA, 179.76 +/- 60.46, 209.67 +/-& nbsp; 69.84, 67.41 +/- 32.22, P < 0.001, respectively, aIMA, 186.22 +/-& nbsp; 64.84, 212.96 +/-& nbsp; 72.84, 68.80 +/- ; 34.42, P < 0.001, respectively). Likewise, IMA and aIMA levels in post-HD patients were higher than pre-HD levels (IMA, 294.62 +/- 66.64, 179.76 +/-& nbsp; 60.46, P < 0.001, respectively, aIMA, 298.31 +/-& nbsp; 70.93, 186.22 & PLUSMN; 64.83, P < 0.001). Linear regression analysis identified glomerular filtration rate as the most effective factor on IMA (P < 0.001). CKD is associated with increased OS and the HD procedure itself also contributes to the increase in OS. IMA may serve as a feasible biomarker for determination of OS.& nbsp;Öğe Correlation of serum galectin-3 level with renal volume and function in adult polycystic kidney disease(Springer, 2019) Ozkurt, Sultan; Dogan, Ibrahim; Ozcan, Oguzhan; Fidan, Nurdan; Bozaci, Ilter; Yilmaz, Behice; Bilgin, MuzafferPurposeThe decrease in kidney functions in autosomal dominant polycystic kidney disease (ADPKD) is strongly correlated with the severity and growth of kidney cysts. Total kidney volume (TKV) was shown to be an early marker of the severity of the disease and a predictor of reduction in kidney functions. New treatment approaches for ADPKD have led to a need for easily applicable strong biomarkers predicting progression of the disease. The profibrotic mediator of galectin-3 (Gal-3) is linked to development of renal fibrosis.MethodsThe study included 74 patients with ADPKD diagnosis and 40 healthy controls. The TKV of patients was calculated using the manual tracing method on MR images. The serum Gal-3 levels of patient and healthy control groups were measured with the ELISA method. The correlations between serum Gal-3 value with TKV and kidney function were assessed in patients.ResultsAs the stage of chronic kidney disease (CKD) increased, serum Gal-3 and TKV values increased (p<0.001, p=0.049, respectively). Correlation analysis found a negative relationship between serum Gal-3 levels and eGFR (r: -0.515, p<0.001); however, there was no relationship between serum Gal-3 and TKV (r=0.112, p=0.344). Linear regression analysis showed the major parameter affecting Gal-3 was eGFR (p=0.016).ConclusionsIn our study, we showed that renal impairment is an important determinant of Gal-3, and there is no correlation of Gal-3 and TKV in ADPKD. As a result, there is an urgent clinical need for new biomarkers to identify individuals with the chance of treatment in the early stage among ADPKD patients.Öğe Investigation of mindin levels in hypertensive patients with left ventricular hypertrophy and QRS fragmentation on electrocardiography(Taylor & Francis Ltd, 2018) Dogan, Tolga; Yetim, Mucahit; Celik, Oguzhan; Kalcik, Macit; Ozcan, Oguzhan; Dogan, Ibrahim; Erenler, Ali KemalPurpose: Mindin was associated with diabetic nephropathy, podocyte injury, colitis, allergic asthma, liver ischaemia and reperpusion injury and ischaemic brain injury. On the other hand, it was reported as a protective factor against obesity, cardiac hypertrophy, fibrosis and remodelling. Fragmented QRS complexes (fQRS) are markers of altered ventricular depolarisation owing to a prior myocardial scar and fibrosis. In this study, we aimed to investigate mindin levels in hypertensive patients with left ventricular hypertrophy and fQRS on electrocardiography. Methods: This observational case-control study enrolled 70 (36 female) hypertensive patients with fQRS and 38 (23 female) hypertensive control patients. All patients were evaluated by transthoracic echocardiography. Mindin levels were measured by the enzyme-linked immunosorbent assay (ELISA). Clinical, echocardiographic and laboratory data were compared between patient and control groups. Results: There was no significant difference between patient and control groups in terms of clinical, echocardiographic and routine laboratory parameters. The mindin levels were significantly higher in the patient group than controls (11.3 (7.21-19.31) vs 4.15 (2.86-6.34); p < .001). Multiple logistic regression analyses defined increased mindin levels as an independent predictor for the presence of fQRS (Odds ratio: 1.733; p = .034). Mindin levels >6.74 predicted the presence of fQRS with a sensitifity of 84.3% and specificity of 79.9% on receiver operating characteristic (ROC) curve analysis (The area under the curve:0.889; Confidence Interval: 0.827-0.951; p < .001). Conclusion: Mindin expressin is upregulated in hypertensive patients with fQRS complexes. In contrary to previous studies, increased mindin levels may be associated with myocardial fibrosis.Öğe IS OXIDATIVE STRESS ASSOCIATED WITH TOTAL KIDNEY VOLUME IN PATIENTS WITH AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE?(Oxford Univ Press, 2020) Dogan, Ibrahim; Eser, Bads; Aydemir, Nihal; Kayadibi, Huseyin; Ozcan, Oguzhan; Fidan, Nurdan; Ozkurt, Sultan[Abstract Not Available]
