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Öğe ARACHNOID CYST CAUSING SUBFALCINE HERNIATION IN A CHILD FAILURE TO THRIVE(Nobel Ilac, 2011) Dogan, Murat; Yilmaz, Cahide; Ustyol, Lokman; Caksen, HuseyinArachnoid cysts represent only 1% in all intracranial masses. The signal and density of arachnoid cysts are mostly the same as cerebrospinal fluid unless be complicated. They do not have calcification and do not retain contrast material but they are benign lesions. Although they can be seen in all ages, they are mostly detected in children. Male-female ratio is In this case report., 18 months-old-boy with subfalcine herniation because of an arachnoid cyst who was brought to our hospital only with complaint of failure to thrive was presented due to its atypical and rare presentation.Öğe Comparison of Lung graphy and thorax computed tomography findings in children with Tuberculin skin test positive(Medknow Publications & Media Pvt Ltd, 2012) Efe, Evrim; Arica, Vefik; Dogan, Murat; Arica, Secil GunherAim: Benefit of thorax computed tomography was investigated when lung graphy remains insufficient in the diagnosis of tuberculosis. Materials and Methods: 55 patients across children with tuberculin skin test (TST) positive nonspecific symptom who applied to the tuberculosis polyclinic of our hospital were investigated between ages of 0-18, determined positivity in their TST test or with tuberculosis contact story. Age, gender, complaining, TST results, existence/number of BCG scar, underlying disease, contact status, cigarette exposure, laboratory findings, Lung graphy and thorax CT findings of patients were compared. Results: Average age of cases was 110, 38 +/- 42, 8 months. Lung graphy results of 36.4% of cases were abnormal while 63.6% were normal. Results of 30.9% (n=17) were abnormal while 69.1% (n=38) of cases were normal. No compliance is observed between results of CT and Lung graphy (p<0.05). Lung graphy was found to have a low positive true diagnosis value, a higher negative true diagnosis value. A significant difference is observed between tuberculosis sighting case and scar numbers of BCG (p<0.05). Conclusion: Taking lung graphy and thorax CT is beneficial and significant in the investigation of tuberculosis disease in patients with positivity of tuberculin skin test. Computed tomography is more sensitive method in comparison to lung graphy in terms of all findings.Öğe CONGENITAL HYPOTHYROIDISM WITH ISOLATED FIBULA AGENESIS(Nobel Ilac, 2010) Dogan, Murat; Yilmaz, Cahide; Caksen, Hueseyin; Cesur, Yasar; Akpinar, Fuat; Gueven, Ahmet SamiAlthough congenital hypothyroidism is seen often as an isolated case, it can also be seen as a part of some syndromes like Schinzel-Giedion, Aicardi-Goutieres-like, cleidocranial dysplasia and deletion of 18q. It is also well known that congenital hypothyroidism may be associated with other congenital malformations, especially with cardiac heart diseases, skeletal abnormalities, Central nervous system and eye malformations. In this article, 11-years-old-girl with fibula agenesis associated with congenital hypothyroidism because of thyroid gland hypoplasia is presented. In our knowledge, both congenital hypothyroidism and isolated fibula agenesis have not been published before in the literature.Öğe Convulsion in infants as a result of oral use of garden sage(Galenos Yayincilik, 2012) Arica, Vefik; Arica, Secil; Tutanc, Murat; Motor, Sedat; Motor, Vicdan Koksaldi; Dogan, MuratSalvia officinalis is a plant known as Garden Sage and it is used by the community in case of various clinical conditions. Herbalists are the right destinations to provide this special plant. Salvia officinalis is known to be used for its diuretic, anti-inflammatory, antimicrobial, antiseptic, expectorant, spasmolytic and diaphoretic effects. In this case study, a case of intoxication in which a 2-month old infant who presented with convulsion due to accidental oral use of garden sage oil which was actually prepared for topical use by a herbalist is reported. (Turk Arch Ped 2012; 47:67-8)Öğe Daily and every other day use of iron prophylaxis in the first year of life(Galenos Yayincilik, 2010) Arica, Vefik; Arica, Secil; Tutanc, Murat; Motor, Sedat; Onur, Hatice; Dogan, MuratAim: In countries like Turkey where iron deficiency anemia (IDA) is common, it was that iron prophylaxis can be used every other day as intermittent because it would show the same effect and easier for compliance. Material and Method: Two groups of infants born healthy, breastfed exclusively for the first six months and given 400 IU vitamin D were included in the study. In the fourth month of their life, infants started to take iron (Fe +2) 1 mg/kg/day and the second group 2 mg/kg/48 h In use of daily 1 mg/kg/day dose as of the fourth month till the first year 75 patients (the first group), in use of 2 mg/kg/48 h 80 patients (the second group) were involved in our study group. 34 infants (the third group) who did not start to take iron prophylaxis or use any was taken in our study as a control group. Results: It was found out that in the first group 14 infants (18.6%) developed iron deficiency (ID), 3 infants (4%) iron deficiency anemia (IDA), in the second group 16 infants (20%) developed ID and 4 infants (5%) IDA, in the third group, namely in the control group 12 infants (35,3%) developed ID and 10 infants (29.4%) IDA. In comparison of the control group with the first and second groups, IDA portion was less in iron prophylaxis groups, this value was found statistically reliable (p=0.001). When the first and second groups were compared with one another, a statistical difference could not be found between ID/IDA proportions. Because ID and IDA were encountered in both prophylaxis groups it was assumed that iron prophylaxis given just during the first year of life should also be given afterwards. Conclusions: There is no statistical difference between the first and second prophylaxis groups, thus, it was considered that instead of daily use, taking iron every other day would be more effective when it was given in a proper dose. (Turk Arch Ped 2010; 45: 343-7)Öğe Development of acute dystonia in three brothers due to metoclopramide(Isfahan Univ Med Sciences, 2012) Silfeler, Ibrahim; Arica, Vefik; Arica, Secil; Dogan, MuratOne of the agents that cause dystonic reactions is metoclopramide. In this study, we presented three individuals of the same family who were admitted to our hospital while receiving the treatment of metoclopramide because of developing acute dystonic reaction. Appropriate doses of metoclopramide therapy had begun to all brothers with a diagnosis of gastroenteritis. After receiving the first dose of medication, acute dystonia was observed within half an hour in these brothers who used metoclopramide. Thus, if there is a patient who developed acute dystonia in the same family due to metoclopramide, avoiding from use of metoclopramide will be beneficial for other members of the family.Öğe The effect of the length of the prodromal period on the metabolic control within the first 2 years in children with diabetic ketoacidosis manifestation(Walter De Gruyter & Co, 2011) Murat, Zehra; Arica, Vefik; Dogan, Murat; Arica, Secil GunherPurpose: We investigated the effects of clinical and laboratory properties at the time of the initial application of patients recently diagnosed and presenting metabolic indicators of diabetic ketoacidosis who were given disease prognoses in years 1 and 2 after discharge. Materials and methods: A total of 94 patients admitted to Bakirkoy Maternity and Children's Diseases Training and Research Hospital with diabetic ketoacidosis and recently diagnosed with type 1 diabetes mellitus were investigated. Patient files were examined within 2 years following discharge. Findings: All 94 study patients (53.2% male and 46.8% female) presented acidosis, ketonuria and hyperglycemia. While a moderate correlation was detected between the prodromal period and HbA(1c) values in year 1, only a slight correlation was seen in HbA(1c) values in year 2. In addition, a slight correlation was observed between the prodromal period and the number of hospitalizations due to diabetic ketoacidosis in the first year. Again, while a moderate correlation was observed between HbA(1c) values and the number of hospitalizations due to diabetic ketoacidosis in year 1, only a slight correlation was seen in year 2. The prodromal period was directly proportional to patient age. Results: Hospital admissions may be reduced through appropriate treatment, follow-up and metabolic control of patients with type 1 diabetes mellitus. In addition, we report a relationship between the prodromal period and HbA(1c) values in type 1 diabetes patients.Öğe Evaluation of Lymphocyte Subgroups in Children With Down Syndrome(Sage Publications Inc, 2015) Yilmaz, Cahide; Dogan, Murat; Basarslan, Fatmagul; Yilmaz, Nebi; Yuca, Sevil; Bulan, Keziban; Kaya, AvniIn this study, lymphocyte subgroups including blood CD3, CD4, CD8, CD4/CD8, CD19, and CD16.56 values were analyzed in children with Down syndrome (DS). The study includes 85 children with DS, followed at Department of Pediatrics, Faculty of Medicine, Yuzuncu Yil University and 64 healthy age-matched control participants. Blood CD3, CD4, CD8, CD4/CD8, CD19, and CD16.56 values were examined in both the groups. Significantly decreased blood CD3, CD4, and CD19 values were found in the study group (P < .05) when compared with the control group. In conclusion, we would like to emphasize that blood CD3, CD4, and CD19 levels were found to be decreased in children with DS. Based on these finding, we think that these decreased lymphocyte subgroups might be responsible for increased susceptibility to infections in children with DS.Öğe LATE ONSET ARGININE SUCCINATE LYASE DEFICIENCY WITH NORMAL PLASMA AMMONIA LEVEL(Nobel Ilac, 2011) Yilmaz, Cahide; Dogan, Murat; Cesur, Yasar; Caksen, Huseyin; Yuca, Sevil Ari; Atas, Bulent; Tuncer, OguzArginine succinate lyase (ASL) deficiency is one of the most common cause of urea cycle defect and shows all characteristics of this disorders. This disease is presented with hyperammonemia, abnormally kinky hair and mental retardation. 6-years-old-girl was brought to our hospital because of skin eruption, weight loses, abdominal pain, having no appetite, polydipsia and pollakiuria. In physical examination, especially occipital balding, mental retardation, hepatomegaly, ataxia and articulation defect were found. She, who was diagnosed as ASL deficiency after the laboratory examinations, had normal blood ammonia levels. Finally in this study, we emphasize; ASL deficiency must be thought when a child has mental retardation and cerebellar ataxia, even if normal ammonia levels.Öğe Nitric oxide, lipid peroxidation, and antioxidant enzyme levels in epileptic children using valproic acid(Elsevier Science Bv, 2009) Peker, Erdal; Oktar, Sueleyman; An, Mustafa; Kozan, Ramazan; Dogan, Murat; Cagan, Eren; Soeguet, SadikIn the present study, we investigated the effects of valproic acid (VPA) on nitric oxide (NO) level, lipid peroxidation, and antioxidant enzyme activities in 21 epileptic children and 26 healthy controls. The subjects were selected from those who visited for a checkup or medical treatment at the Mustafa Kemal University Research Hospital. Serum levels of NO-2, NO-3, malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) were analyzed by redox or enzymatic reactions and spectrophotometry. Based on the NO-2 and NO-3 levels, the NO concentration was about 10% higher in VPA group than in the control group (p < 0.001). However, no significant difference was detected for serum MDA, SOD, and CAT levels. It is suggested that NO would play a role in the mechanism of antiepileptic effects by VPA treatment. (c) 2009 Elsevier B.V. All rights reserved.Öğe OPHTALMOPLEGIC MIGRAINE(Nobel Ilac, 2010) Dogan, Murat; Yilmaz, Cahide; Caksen, Huseyin; Guven, A. SamiOpthalmoplegic migraine is characterized with recurrent 3rd, 4th and/or 6th nerve palsy during or following ipsilateral periorbital or temporal headache. In this study, we report four years old child with opthalmoplegic migraine because of a rare occasion. The patient was brought to our hospital for the first time due to ptosis following headache, which continued for 4 days. From the history, it was learned that one year ago, ptosis which lasted for one week following headache, had occurred too. Neurological examination was normal except the complete third nerve palsy. Cranial magnetic resonance imaging and electroencephalography examinations were normal. One year later, the patient was brought to us again with the same complaint. Since the attacks were so few we didn't give him migraine proflaxy and we advice him to use analgesic during the attacks. The patient still comes to our hospital for periodic controlsÖğe Prazosin treatment in the management of scorpion envenomation(Sage Publications Ltd, 2010) Peker, Erdal; Oktar, Suleyman; Dogan, Murat; Kaya, Ergun; Duru, MehmetScorpion stings represent an important and serious public health problem worldwide due to their high incidence and potentially severe and often fatal clinical manifestations. Children are at greater risk of developing severe cardiac, respiratory, and neurological complications due to lesser body surface area. Alpha receptor stimulation plays important role in the pathogenesis of pulmonary edema. Prazosin, a post synaptic alpha blocker, can be recommended as an effective drug in the treatment of serious scorpion envenomations with significant sympathetic symptoms. Oral prazosin is fast acting, easily available, relatively cheap, free from any anaphylaxis and highly effective.Öğe Protective Effect of Colchicine on Ovarian Ischemia-Reperfusion Injury: An Experimental Study(Springer Heidelberg, 2015) Kurt, Raziye Keskin; Dogan, Ayse Citil; Dogan, Murat; Albayrak, Aynur; Kurt, Sefika Nur; Eren, Furkan; Okyay, Ayse GulerObjective: The aim of the present study is to investigate the efficiency of colchicine in the experimental rat ovarian torsion model in the light of histological and biochemical data. Study Design: A total of 35 Wistar albino female rats were randomly divided into 5 groups, group 1: (control-sham operated, n = 7); group 2: (torsion/detorsion, n = 7) 2 hours of ischemia and 2 hours of reperfusion; group 3: (torsion/detorsion, n = 7), 2 hours of ischemia and 5 days of reperfusion; group 4: (torsion/detorsion, n = 7) 2 hours of ischemia and 2 hours of reperfusion and a signal dose of oral 1 mL/kg colchicine; and group 5: (torsion/detorsion, n = 7), 2 hours of ischemia and 5 days of reperfusion and 5 days of oral 1 mg/kg colchicine. Histopathologic evaluation was performed by a scoring that assesses congestion, bleeding, edema, and cellular degeneration in the ovarian tissue. Catalase, tissue malondialdehyde (MDA), and protein carbonyl levels were calculated. Results: The histopathologic scores, MDA, and protein carbonyl levels in the control and colchicine groups were significantly lower than groups 2 and 3 (P < .001). Catalase activities were significantly higher in the control and colchicine groups than in groups 2 and 3 (P < .001). The results of the histopathologic parameters and biochemical markers showed that protective effects of colchicine treatment persisted up to 5 days. Conclusion: Our study results revealed that colchicine reduced ovarian ischemia-reperfusion injury in experimental rat ovarian torsion model. As the ovarian detorsion is the first choice of the treatment modality in the early phase, antioxidant and anti-inflammatory treatment modalities like colchicine might be used to reduce ovarian ischemia-reperfusion injury.Öğe A rare tuberculosis form: congenital tuberculosis(Turkish Assoc Tuberculosis & Thorax, 2010) Peker, Erdal; Bozdogan, Erol; Dogan, MuratCongenital tuberculosis is defined as infection developing as a result of the encounter between the infant and Mycobacterium tuberculosis bacilli during the intrauterine period or during normal birth. Although tuberculosis infection is very common all over the world congenital tuberculosis cases are rare and mortalities of 50% have been reported. Nonspecific symptoms in congenital tuberculosis and difficulties encountered in the diagnosis of tuberculosis in general, make it difficult to reach a final diagnosis. Cases of congenital tuberculosis are generally known clinically during the first postnatal month. This case is important as the three-month infant was presented with pneumonia symptoms and diagnosed as congenital tuberculosis after an attentive anamnesis which is unusual during three postnatal months. To our knowledge, this case is one of a few cases in the literature diagnosed as congenital tuberculosis in three months. Our case emphasizes that it is necessary to consider congenital tuberculosis in the differential diagnosis of pulmonary infections in infants, particularly in countries where the incidence of tuberculosis is high. For this reason, we believe that a successfully obtained anamnesis is the parameter which provides a valid diagnosis. Furthermore, early and speedy initiation of treatment in cases with a potential diagnosis of tuberculosis is a very important factor that affects prognosis.Öğe Vitamin B12 deficiency with presenting nutritional difficulty: A case report(Dr Behcet Uz Cocuk Hastaliklari Ve Cerrahisi, 2012) Arica, Vefik; Silfeler, Ibrahim; Arica, Secil Gunher; Tutatanc, Murat; Dogan, Murat; Gucuk, SebahatVitamin B12 deficiency is among important causes of megaloblastic anemia. In developing countries, the major reason of Vitamin B12 deficiency is deficient dietary intake. Although vitamin B12 deficiency is a rare condition, early diagnosis and treatment are important to prevent permanent neurological sequela. Anorexia is seen frequently in children. We want to remind Vitamin B12 deficiency with this case presented with anorexia. A 12 month-old male patient presented with vomiting, weight loss, paleness, malnutrition, repulsion as well as growth retardation. Physical examination revealed paleness and loss of interest to environment. Hematologic test results were as follows: WBC: 6500 gr/dl, Hgb: 8.8 gr/dl, MCV: 96 fl, platelet count: 162.000/mm(3). Mean serum folic acid level of the patient was 19.4 ng/mL (3-22.4 ng/mL), and vitamin B12 level 72 pg/mL (200-1210 pg/mL), while mean vitamin B12 level of the mother was 96 pg/mL. The patient was diagnosed as vitamin B12 deficiency and intramuscular Vitamin B12 treatment was initiated. One month later, his vomiting ceased, his appetite was well and he gained 850 gr. His interest to environment was improved. We want to impress with this case that infants with anorexia might have vitamin B12 deficiency. Treatment of vitamin B12 deficiency is important because it might lead to permanent neurological sequela and vitamin B12 deficiency respond to treatment dramatically.Öğe Zofenopril attenuates injury induced by ischemia-reperfusion on rat ovary(Wiley, 2015) Kurt, Raziye Keskin; Dogan, Ayse Citil; Dogan, Murat; Albayrak, Aynur; Kurt, Sefika Nur; Eren, Furkan; Silfeler, Dilek BenkAimThe aim of the study was to investigate the effectiveness of zofenopril in an experimental model of ovarian torsion in rats with histologic and biochemical assessments. Material and MethodsExperimental procedures were performed on 35 female rats (Wistar albino). Rats were randomly divided into five groups as: sham (sham operated, n=7); vehicle group 1 (torsion-detorsion, n=7) with 2h ischemia and 2h reperfusion; vehicle group 2 (torsion-detorsion, n=7) with 2h ischemia and 5 days' reperfusion; zofenopril group 1 (torsion-detorsion, n=7) with 2h ischemia, 2h reperfusion and a signal dose of oral 15mg/kg zofenopril; and zofenopril group 2 (torsion-detorsion, n=7) with 2h ischemia, 5 days' reperfusion and 5 days' oral 15mg/kg zofenopril. A scoring of histopathologic evaluation was performed on the ovaries according to congestion, bleeding, edema, and cellular degeneration. Biochemical assessments included catalase, tissue malondialdehyde and protein carbonyl. ResultsCompared with the vehicle groups, histopathologic scores, tissue malondialdehyde and protein carbonyl levels, which reflect oxidative stress markers, were significantly lower in the zofenopril groups. Furthermore, catalase levels were significantly increased in the zofenopril group. ConclusionOur study results revealed that zofenopril attenuates injury induced by ischemia-reperfusion on rat ovary.
