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Öğe Advanced recurrent pterygium leading to significant visual impairment(Taylor & Francis Ltd, 2020) Kurtul, Bengi Ece; Elbeyli, Ahmet; Koca, Suleyman[Abstract Not Available]Öğe Assessment of platelet-to-lymphocyte ratio in patients with retinal vein occlusion(Sage Publications Ltd, 2020) Kurtul, Bengi Ece; cakmak, Ayse Idil; Elbeyli, Ahmet; Oezarslan oezcan, Deniz; Oezcan, Sait Coskun; Cankurtaran, VeyselPurpose: To investigate platelet-to-lymphocyte ratio (PLR) in retinal vein occlusion (RVO) patients. Methods: In this study, we retrospectively reviewed data of 32 patients with RVO (RVO group) and 32 age- and sex-matched participants without RVO (control group) between January 2017 and March 2019. The PLR was determined by dividing the platelet count by the lymphocyte count. Results: Age and gender were comparable between the groups (p = 0.204 and p = 0.800, respectively). PLR was significantly elevated in the RVO group compared with the control group (137 (113-164) vs 101 (86-129), p = 0.001)). In the receiver operator characteristics curve analysis, the optimal cut-off value of PLR for predicting RVO was 123, with 69% sensitivity and 72% specificity. Conclusion: We report that PLR are elevated in RVO, suggesting that PLR may be a useful marker for RVO.Öğe Assessment of Red Cell Distribution Width, Platelet/lymphocyte Ratio, Systemic Immune-inflammation Index, and Neutrophil/lymphocyte Ratio Values in Patients with Central Retinal Artery Occlusion(Taylor & Francis Inc, 2022) Elbeyli, Ahmet; Kurtul, Bengi Ece; Ozcan, Deniz Ozarslan; Ozcan, Sait Coskun; Dogan, EminePurpose To evaluate complete blood count (CBC)-derived inflammatory indices in central retinal artery occlusion (CRAO). Methods A total of 42 patients with CRAO (CRAO group) and 42 age- and sex-matched subjects without CRAO (Control group) were included. CBC parameters including red cell distribution width (RDW) levels were assayed. Platelet/lymphocyte ratio (PLR), systemic immune-inflammation index (SII) and neutrophil/ lymphocyte ratio (NLR) were calculated. Results RDW, PLR, SII and NLR values were significantly higher in CRAO group than control group [15.2 +/- 1.47% vs 13.96 +/- 1.13% (p < .001), 127.94 +/- 48.21 vs 101.16 +/- 24.84 (p = .008), 667.11 +/- 357.84 vs 493.44 +/- 207.07 (p = .008), 2.70 +/- 1.27 vs 2.13 +/- 0.83 (p = .018), respectively]. In multivariate analysis only RDW was independent predictor for CRAO (OR 2.317, p < .001). On ROC analysis, area under curve of RDW, PLR, SII, and NLR for CRAO were 0.761, 0.685, 0.622 and 0.618, respectively. Conclusion RDW seems superior to other inflammatory indices to predict CRAO.Öğe Association of childhood obesity with retinal microvasculature and corneal endothelial cell morphology(Walter De Gruyter Gmbh, 2021) Kurtul, Bengi Ece; Cakmak, Ayse Idil; Elbeyli, Ahmet; Karaaslan, Abdulkerim; El, CigdemObjectives: To investigate the optical coherence tomography angiography (OCTA) and specular microscopy (SM) findings in obese children and compare them with healthy ones. Methods: In this prospective study, 50 eyes of 25 obese children [body mass index (BMI) >= 95th percentile], 36 eyes of 18 control age- and sex- matched healthy subjects (BMI <85th percentile) were included. Demographic features and ophthalmological examination including OCTA measurements as well as SM findings were assessed. Cellular morphology was observed by noncontact SM and results for corneal endothelial cell density (cells/mm(2)), coefficient of variation of cell size and percentage of hexagonal cells were obtained. The OCTA was performed with 6 x 6 mm sections for macula and 4.5 x 4.5 mm sections for optic disc in all eyes. Foveal retinal thickness (FRT), retinal nerve fiber layer (RNFL) thickness, vessel density in different sections of retina and optic nerve head were analyzed. Results: All SM parameters, RNFL thickness for average, and all quadrants and optic disc radial peripapillary capillary densities were similar between groups. However, FRT, flow area for choriocapillaris, superficial and deep foveal capillary densities were significantly higher in obese group when compared to controls (242.4 +/- 18.2 mu m vs. 232.1 +/- 16.5 mu m, p=0.024, 2.2 +/- 0.1 mm(2) vs, 2.2 +/- 0.0 mm(2), p=0.042, 22.4 +/- 6.9% vs. 15.6 +/- 5.5%, p=0.001, and 38.9 +/- 7.5% vs. 31.1 +/- 8.6 %, p=0.001, respectively). Conclusions: Obese children seem to have higher values of FRT, flow area for choriocapillaris, superficial and deep foveal capillary densities. These results may have significant implications for understanding of how childhood obesity could affect retinal microvasculature.Öğe Changes in the cornea related to sickle cell disease: a pilot investigation(Wichtig Publ, 2015) Coskun, Mesut; Ilhan, Ozgur; Ilhan, Nilufer; Tuzcu, Esra Ayhan; Daglioglu, Mutlu Cihan; Kahraman, Hilal; Elbeyli, AhmetPurpose: To investigate corneal structural changes (central corneal thickness, endothelial cell count, and cellular morphology) in patients with sickle cell disease (SCD). Methods: This prospective study included 56 patients with SCD and 50 age- and sex-matched healthy subjects without any eye disease aside from refractive errors. Endothelial cell density (ECD), percentage of hexagonality, and the coefficient of variation in cell size (CV) were measured using noncontact specular microscopy, and central corneal thickness (CCT) was measured by pachymetry. Results: The mean CCT value was 509.6 +/- 20.7 mu m in the study group and 520.8 +/- 23.6 mu m in the control group. The mean ECD, CV, and percentage of hexagonality values in the study group were 2712 +/- 335 cells/mm(2), 34.5 +/- 5.3%, and 57.2 +/- 6.6%, respectively, and 3030 +/- 247 cells/mm(2), 31.6 +/- 5.0%, and 60.4 +/- 6.9% in the control group, respectively. Endothelial cell density (p = 0.001), CCT (p = 0.011), CV (p = 0.005), and percentage of hexagonality values (p = 0.018) were significantly different between the study and control groups. Conclusions: The results of the current study indicate that patients with SCD had considerable morphologic changes in the structure of the cornea when compared to healthy subjects.Öğe Comparison of Different Topographic Reference Surfaces in Keratoconus Cases(2021) Elbeyli, Ahmet; Kocamış, Sucattin İlker; Çakmak, Hasan Basrı; Doğan, EmineOBJECTİVE: To compare the sensitivity and specificity of elevation maps obtained from different topographical reference surfaces used in the diagnosis of keratoconus. MATERİALS AND METHODS: In this study 40 eyes of 23 patients with keratoconus and 40 eyes of 25 refractive surgery candidates as a control group was measured with a Scheimpflug camera (Sirius CSO-Italy). Using the receiver operator characteristic curves (ROC), a comparison was made of the ability to differentiate keratoconus from a normal cornea with anterior elevation(AE) and posterior elevation(PE) measurements obtained from the spherical, aspherical, asphero-toric reference surfaces. RESULTS: The ROC curve analysis showed that posterior elevation measured from the aspherical and asphero-toric surfaces had a significantly higher area under the ROC curves (0.987, 0.973 respectively) thanthevalueobtainedfromthesphericalreferencesurfaces. According to the data obtained from the ROC curve analysis, the posterior elevation maps obtained from the aspherical and asphero-toric reference surfaces had the highest sensitivity (97.5% for both) and the posterior elevation map obtained from the aspherical reference surface had the highest specificity (90%). CONCLUSION: The highest sensitivity and specificity values were obtained from the aspherical and asphero-toric reference surfaces rather than from the spherical reference surface. When compared to the anterior elevation values, the posterior elevation values were found to be more sensitive and specific. Therefore, aspherical and asphero-toric reference surfaces and a posterior elevation map would seem to be more accurate in the differentiation of keratoconus and normal cornea.Öğe Corneal endothelial cell density and microvascular changes of retina and optic disc in autosomal dominant polycystic kidney disease(Wolters Kluwer Medknow Publications, 2021) Kurtul, Bengi Ece; Elbeyli, Ahmet; Kakac, Ahmet; Turgut, FarukPurpose: Vascular endothelial dysfunction in autosomal dominant polycystic kidney disease (ADPKD) may affect the retinal vascular parameters due to structural similarities of kidney and retina. We aimed to evaluate the microvascular changes of retina and optic disc and also corneal endothelial cell density in patients with ADPKD. Methods: Forty-six eyes of 23 patients with ADPKD (Group 1), and 46 eyes of 23 sex- and age-matched healthy controls (Group 2) were included in this cross-sectional study. Demographic and ophthalmic findings of participants were collected. Corneal endothelial cell density (CECD) measurements were obtained by noncontact specular microscopy. Foveal retinal thickness, peripapillary retinal nerve fiber layer (RNFL) thickness, vessel density in different sections of the retina and optic nerve head were analyzed by optical coherence tomography angiography. Results: The mean ages were 41 +/- 11 years for Group 1 and 39 +/- 10 years for Group 2 (P = 0.313). CECD values were significantly lower in group 1 when compared to group 2 (2653 +/- 306 cells/mm(2) and 2864 +/- 244 cells/mm(2), respectively, P < 0.001). The foveal retinal thickness and RNFL thickness were similar, but superior quadrant thickness of RNFL was significantly lower in Group 1 than Group 2 (126 +/- 14 mu m vs. 135 +/- 15 mu m, P = 0.003). In Group 1, whole image of optic disc radial peripapillary capillary densities were significantly lower compared to Group 2 (49.4 +/- 2.04%, and 50.0 +/- 2.2%, respectively, P = 0.043). There was no significant difference regarding superficial, deep retinal vessel densities, foveal avascular zone and flow areas between the groups (P > 0.05 for all). Conclusion: Lower CECD values and decreased superior quadrant RNFL thickness, and microvascular densities of optic disc were revealed in patients with ADPKD. Evaluation of CECD and retinal microvasculature may be helpful in the management of these patients.Öğe The diagnostic value of systemic immune-inflammation index in diabetic macular oedema(Taylor & Francis Ltd, 2022) Elbeyli, Ahmet; Kurtul, Bengi Ece; Ozcan, Sait Coskun; Ozcan, Deniz OzarslanBackground This study evaluates the diagnostic value of systemic immune-inflammation index (SII) in the occurrence of DME in patients with non-proliferative diabetic retinopathy. Methods In this prospective study, the SII was applied to 150 consecutive patients with non-proliferative diabetic retinopathy. The relationship between the SII and the occurrence of DME was examined. Patients with DME were also divided into two subgroups according to the presence of accompanying sub-retinal fluid. The SII value was calculated as follows: platelet count x (neutrophil/lymphocyte). The risk factors for DME were evaluated using multivariate logistic regression analysis. A receiver operating characteristic (ROC) curve analysis of SII for predicting DME was performed. Results Patients with DME had significantly higher levels of SII than those without DME (599.7 +/- 279.2 and 464. 9 +/- 172.2, respectively, p < 0.001). However, The SII values were similar between sub-retinal fluid subgroups. Multivariate regression analysis indicated that SII, together with duration of diabetes, was an independent factor for DME occurrence [Odds ratio (OR) = 1.005, 95% confidence interval = 1.001-1.009, p = 0.04, and OR = 1.146, 95% CI = 1.049-1.252, p = 0.003, respectively]. ROC curve analysis revealed that the best cut-off value of SII was 399 (area under the curve: 0.633; sensitivity: 70%; specificity: 60%). Conclusion An elevated SII value is strongly associated with the development of DME. The SII may be a diagnostic biomarker for identifying DME to improve the risk stratification and management of non-proliferative patients with diabetic retinopathy.Öğe Effect of intravitreal injection of dexamethasone implant on corneal endothelium in macular edema due to retinal vein occlusion(Taylor & Francis Ltd, 2015) Ilhan, Nilufer; Coskun, Mesut; Ilhan, Ozgur; Tuzcu, Esra Ayhan; Daglioglu, Mutlu Cihan; Elbeyli, Ahmet; Keskin, UgurcanObjective: To evaluate the effects of dexamethasone (DEX) implant (Ozurdex(R)) on corneal endothelium in patients with retinal vein occlusion complicated with macular edema. Materials and methods: Patients (n = 31) received 1-3 intravitreal DEX implants in one eye. Measurements were intraocular pressure (IOP) at baseline and 1, 3, and 6 months after the first intravitreal injection and corneal specular microscopy and central corneal thickness (CCT) at baseline and 1 and 6 months. We analyzed endothelial cell density (ECD), coefficient of variation of cell size (CV), and percentage of hexagonality. Results: Mean follow-up period was 9.7 +/- 3.3 months. Mean number of injections was 1.5 +/- 0.8. Mean IOP values were 15.6 +/- 2.6mm Hg at baseline, 17.7 +/- 3.6mm Hg at one month, 16.4 +/- 4.1mm Hg at three months, and 16.0 +/- 2.7mm Hg at six months. There was a significant difference in mean IOPs at one month and six months (p = 0.008). There were no significant differences in mean ECD (p = 0.375), CV (p = 0.661), percentage of hexagonality (p = 0.287), and CCT (p = 0.331). Conclusion: Although intravitreal injection of 0.7mg DEX causes moderate elevation of IOP, it does not seem to have detrimental effects on corneal endothelium at six months.Öğe Epidemiological and Clinical Characteristics of Childhood Open Eye Injuries in the South of Anatolia(2021) Cakmak, Ayse Idil; Kakaç, Ahmet; Khaleqı, Zikria; Cankurtaran, Veysel; Özcan, Sait Coşkun; Elbeyli, Ahmet; Çetin, ŞirinPurpose: The aim of this study is to determine the demographic, epidemiological and etiological characteristics of pediatric patients presented\rwith open eye injury (OEI).\rMaterials and Methods: We retrospectively reviewed medical records of the children who presented with OEI to a tertiary eye care center\rbetween January, 2017 and July, 2019. The cases were stratified into two groups as preschool (2-5years) and school-age (6-16years) children.\rResults: The study included 39 eyes of 37 cases. The mean age was 7.38±4.01 years and male: female ratio was 1.85. The study included 22\reyes of 22 preschool and 17 eyes of 15 school-age children. It was seen that the most common OEIs were OEI by a sharp object (25 cases;\r64.1%), penetrating OEI (35 cases; 89,7%), zone I OEI (19 cases; 48.7%), corneoscleral OEI (19 cases; 48.7)) and small OEI (<5 mm in size)\r(18 cases;46,2%). Intraocular foreign body was detected in 5 cases (12.8%). No significant relationship was found between lens damage and\rcause of trauma (p=0.427); whereas there was a significant correlation between size of injury and retinal detachment (p<0.0001 for both). It was\rfound that there was bilateral OEI in 2 of 5 cases injured during the Syrian civil war and that 3 cases underwent evisceration.\rConclusion: Unlike the children who were seriously injured in the war environment, it was determined that children in peace environment were\rexposed to OEI with milder symptoms, mostly by preventable reasons. The results of this study show the severe effects of war on children; in\raddition, it may help to raise awareness and take first steps for prevention of OEI in children in peace.\rKeywords: Eye injuries, open-globe injury, trauma.Öğe Evaluation of systemic immune-inflammation index level as a novel marker for severity of noninfectious uveitis(Springer, 2021) Kurtul, Bengi Ece; Cakmak, Ayse Idil; Elbeyli, Ahmet; Ozcan, Sait Coskun; Ozcan, Deniz Ozarslan; Kimyon, GezmisPurpose To evaluate the association of systemic immune-inflammation index (SII) levels, neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) with severity of noninfectious uveitis. Methods This retrospective study included 46 patients with noninfectious uveitis (uveitis group) and 46 age- and sex-matched healthy subjects (control group). The demographic and ocular findings, localization, and activity of uveitis were recorded at the time of onset evaluation. SII, NLR, and PLR levels of patients were compared between the groups. Results SII, NLR, and PLR levels were significantly higher in uveitis group when compared to control group (p < 0.001, p = 0.005, and p = 0.001, respectively). While SII and NLR were significantly higher in severe anterior uveitis than mild anterior uveitis (p = 0.006 and p = 0.021, respectively), only SII was significantly higher in severe posterior and panuveitis than mild ones (p = 0.038). Conclusion SII, as a novel inflammation index, may be more significant tool than NLR and PLR in determining the severity of the uveitis. Furthermore, SII may be a potential useful index in clinical practice to follow-up and manage these patients by monitoring response to anti-inflammatory treatment modalities.Öğe Increased Systemic Immune-Inflammation Index Levels in Patients with Dry Eye Disease(Taylor & Francis Inc, 2022) Ozcan, Deniz Ozarslan; Kurtul, Bengi Ece; Ozcan, Sait Coskun; Elbeyli, AhmetPurpose To evaluate the systemic immune-inflammation index (SII) levels, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in patients with dry eye disease (DED) and to compare with control subjects. Methods This prospective study included 47 DED patients and 47 age- and sex-matched healthy controls. Ophthalmological examination, diagnostic DED tests, and routine complete blood cell count parameters were analyzed. The SII value was calculated as follows: platelet count x (neutrophil/lymphocyte). Results The mean SII, NLR, and PLR levels were significantly higher in DED patients compared to controls (p< .001,pp= .009, respectively). Using the receiver operating characteristics (ROC) curve analysis to predict patients with DED, the highest area under the curve (AUC) was determined SII (0.761 for SII, 0.727 for NLR, and 0.653 for PLR). Conclusions As a novel tool superior to other inflammatory markers, SII may be a cheap and reliable indicator of inflammatory status in DED patients.Öğe The Influence of Topical Cyclopentolate Instillation on Peripapillary and Macular Microvasculature Measured by Optical Coherence Tomography Angiography in Healthy Individuals(Wolters Kluwer Medknow Publications, 2021) Elbeyli, Ahmet; Kurtul, Bengi EcePurpose: To investigate the influence of topical cyclopentolate 1%, as an anti-muscarinic mydriatic agent, on the peripapillary and macular microvasculature by optical coherence tomography angiography (OCT-A) in healthy adults. Methods: A total of 41 healthy adults without any systemic or ocular disease were enrolled for this prospective consecutive study. All patients underwent OCT-A measurements (OptoVue Inc., Freemont, CA, USA) to assess optic disc status for radial peripapillary capillary network (whole image, inside disc, and peripapillaiy capillary densities), and superficial and deep capillary plexus whole, foveal, parafoveal and perifoveal densities, and foveal avascular zone (FAZ) densities. Foveal retinal thicknesses and all quadrant retinal fiber layer thicknesses were also assessed. The 4.5 mm x 4.5 mm peripapillary and 6 mm x 6 mm macular OCT-A images were undertaken before and 30 min after instillation of topical cyclopentolate 1% to the right eyes. Results: The mean age of subjects was 38.14 +/- 14.10 years. All macular, optic disc, and FAZ densities, foveal retinal thicknesses, average, and all quadrant retinal fiber layer thicknesses were statistically similar between baseline and after administration of topical cyclopentolate 1% (P > 0.05). Conclusion: The current study demonstrated that pupillary dilation with topical cyclopentolate 1% seems to have no statistical effect on macular and peripepillary OCT-A measurements of healthy adults.Öğe Investigation of the Retinal and Optic Disc Microvascularization in Polycystic Ovary Syndrome: An Optical Coherence Tomography Angiography Study(Taylor & Francis Inc, 2023) Elbeyli, Ahmet; Kurtul, Bengi Ece; Karapinar, Oya SoyluPurpose To investigate retinal and optic disc microvascular alterations using optical coherence tomography angiography (OCTA) in women with polycystic ovary syndrome (PCOS). Methods Forty-six eyes of 23 patients with PCOS (PCOS group), and 50 eyes of 25 sex and age-matched healthy controls (control group) were included in this cross-sectional study. Foveal retinal thickness, peripapillary retinal nerve fiber layer (RNFL) thickness, vessel density in different sections of the retina and optic disc were analyzed by OCTA. Results The superficial parafoveal vessel densities were significantly lower in PCOS group compared to the control group (53.7 +/- 4.0%, and 55.4 +/- 2.7%, respectively, p = .02). The deep retinal vessel densities, foveal retinal thicknesses and RNFL thicknesses, whole image of optic disc radial peripapillary capillary densities, foveal avascular zone and flow areas were similar between the groups (p > .05 for all). Conclusion OCTA analysis indicates that patients with PCOS tend to have lower superficial parafoveal vessel densities.Öğe Plasminogen activator inhibitor-1 4G/5G polymorphism and dyslipidemia with branch retinal artery occlusion in a young lady(Wolters Kluwer Medknow Publications, 2020) Kurtul, Bengi Ece; Elbeyli, Ahmet; Ozcan, Sait CoskunBranch retinal artery occlusion (BRAO) leads obstruction of blood flow in the distribution of the affected vessel giving rise to ischemia and reorganization of the retinal layers. It is a very rare diagnosis and the etiological risk factors of BRAO are not clean in the young population. Various hypercoagulable states leading to thrombosis appeared to be more responsible. Here, the authors present an interesting case of a 25-year-old female patient with BRAO accompanying with plasminogen activator inhibitor-1(PAI-1) 4G/5G gene polymorphism and dyslipidemia together, for the first time. There was a history of sudden painless blurred vision in her right eye 3 months ago. Her visual acuity was 20/20 in both eyes at the admittion. Fundus photo, red-free photo, optical coherence tomography images of 3 months ago revealed BRAO in the right eye. Fundus exam and images taken at the 3th month confirmed the recovery of retinal edema. Attenuation of inferotemporal retinal artery still mildly appeared. Applied confrontation fields showed a visual field defect corresponding with affected area. Ophthalmologists are advised to be aware of the importance of PAI-1 4G / 5G gene polymorphism and dyslipidemia conditions besides the other genetic mutations and thrombophilic markers regarding BRAO in young patients. © 2020 Wolters Kluwer Medknow Publications. All rights reserved.Öğe Schnyder Corneal Dystrophy: A Rare Case Report(Nepal Ophthalmic Soc, 2020) Kurtul, Bengi Ece; Elbeyli, Ahmet; Ozcan, Deniz Ozarslan; Ozcan, Sait Coskun; Karaaslan, AbdulkerimIntroduction: Schnyder corneal dystrophy (SCD) is a rare, autosomal dominant, anterior stromal dystrophy described as progressive bilateral corneal opacification due to abnormal accumulation of cholesterol and phospholipids in the cornea. The clinical signs can change as the patient ages. SCD with different presentations may actually be misdiagnosed. Early diagnosis would help to rule out other potentially sight threatening or treatable conditions like infectious keratitis or drug toxicity. Case: We present a case of a 34-year-old Syrian male patient, came to our clinic for bilateral decreased visual acuity for 5 years. His visual acuity was 0.15 in both eyes. Slitlamp examination revealed corneal arcus or disk-like lesion and polychromatic crystalline depositions in both eyes in subepithelial and the anterior 1/3 of the stroma. The mild onset of arcus lipoides was also seen. Central corneal thickness results were 507 mu m in the right eye and 503 mu m in the left eye. A diagnosis of Schnyder corneal dystrophy was thought based on clinical presentation and coexistence dyslipidemia of the patient. Conclusion: Ophthalmologists should keep in mind SCD and its associated systemic findings that need to be evaluated and managed properly.Öğe A Series of Civilian Ocular Injuries from the Civil War in Syria(2020) Elbeyli, Ahmet; Kurtul, Bengi EceObjectives: This study aimed to evaluate the demographic and clinical features of eye injury cases in the Syrian Civil War.Methods: A total of 224 eyes of 212 Syrian patients who were referred urgently to Hatay Mustafa Kemal University Facul-ty of Medicine Department of Ophthalmology between January 2011 and December 2018 were evaluated retrospectively. Types of trauma and clinical findings were analyzed.Results: Patients were predominantly male (n=194, 91.5%). The mean age was 29.50±10.76 (range 1–74) years. A total of 30 (14.15%) patients were <18 years old. Most eye traumas (n=177, 79.0%) were open globe injuries, and the remaining 21.0% (n=47) were closed globe injuries. Intraocular foreign body was detected in 106 (47.32%) eyes. Primary repair was performed in 74.10% (n=166) of the cases, and evisceration was performed in 4.46% (n=10).Conclusion: Our study indicated that war conditions can cause serious eye injuries in civilians. These conditions often cause vision and eye loss in adults and children. In addition, all units carrying and treating patient should be strongly coor-dinated to minimize vision, time, and economic losses.Öğe Systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio levels are associated with keratoconus(Wolters Kluwer Medknow Publications, 2021) Elbeyli, Ahmet; Kurtul, Bengi EcePurpose: The aim of this study was to assess the systemic immune-inflammation index (SII) levels, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in patients with keratoconus (KC). Methods: A total of 42 patients with KC (KC group) and 42 age- and sex-matched healthy subjects (control group) were included into this cross sectional study. Complete blood count parameters were assayed. SII, NLR, red cell distribution width (RDW), and PLR values were calculated. The SII value was calculated as follows: platelet count x (neutrophil/lymphocyte). Results: SII, NLR, RDW, and PLR values were significantly higher in KC group compared to control group [709 +/- 236 vs. 418 +/- 117 (P < 0.001), 2.5 +/- 0.8 vs. 1.76 +/- 0.3 (P < 0.001), 14.3 +/- 1.6% vs. 12.9 +/- 0.54% (P < 0.001), and 143 +/- 36 vs. 106 +/- 23 (P < 0.001), respectively]. Using the receiver operating characteristics (ROC) curve analysis to predict KC, the highest area under the curve (AUC) was determined SII (0.846 for SII, 0.778 for NLR, and 0.796 for PLR). Conclusion: SII, NLR, RDW, and PLR levels were significantly increased in patients with KC. This study supports the idea that several inflammatory pathways may play important role in the pathogenesis of this disorder. SII may be much better marker than NLR and PLR for predicting the inflammatory status of the disease.
