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    Changes in selected immunological parameters and oxidative stress responses in different organs of Oncorhynchus mykiss exposed to ivermectin
    (Syscom 18 SRL, 2012) Sakin, Fatih; Yonar, Serpil Mise; Enis Yonar, M.; Sa?lam, Naim
    In this study, effects of ivermectin on selected immunological parameters, oxidative stress, and antioxidant status in the blood, liver, kidney, heart, and spleen of the rainbow trout (Oncorhynchus mykiss) were examined. Ivermectin was administered intraperitoneally at single doses of 0.01 and 0.02 mg ivermectin kg-1 fish. Blood and tissue samples (liver, kidney, heart, and spleen) were then removed on days 3, 7,10, and 14 for immunological and biochemical analyses. The immunological parameters measured were numbers of leucocytes (WBC), nitroblue tetrazolium activity (NBT), total plasma protein (TP), and total immunoglobulin (TI). Malondialdehyde (MDA) values were measured in the liver, kidney, heart, and spleen tissues as indexes of oxidation, and the activities of catalase (CAT), reduced glutathione (GSH), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) were measured as indexes of antioxidant status. The results showed a decrease in the WBC value, NBT activity, and TP and Tl levels after the injection of 0.01 and 0.02 mg ivermectin kg1 fish (p <0.05, 0.01, 0.001). Our results suggest that ivermectin at these doses causes oxidation in fish liver, kidney, heart, and spleen tissues due to impairment of the antioxidant system.
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    Effect of short-term cypermethrin exposure on oxidant-antioxidant balance in the whole body of rainbow trout fry (Oncorhynchus mykiss)
    (2011) Sakin, Fatih; Ispir, Ünal; Yonar, Serpil Mişe; Enis Yonar, M.; Reşk Taysi, M.
    The objective of this study was to investigate the propensity of cypermethrin (CYP) to induce whole body oxidative stress in rainbow trout following exposure. We investigated the effect of CYP (10%, 5%, 2% and 1% of the 4-day rainbow trout flow-through LC 50 1.46 ?g/L CYP) on antioxidants in rainbow trout fry, Oncorhynchus mykiss, using standard laboratory conditions. 24 h exposure caused induction of malondialdehyde (MDA) and various antioxidant enzymes such as catalase (CAT), glutathione peroxidase (GSH-Px) and reduced glutathione (GSH) in the whole body. Fish were monitored for clinical signs. Results obtained showed that CYP significantly (p < 0.05) increased MDA level. Compared to controls, activities of GSH, GSH-Px, and CAT were significantly (p < 0.05) reduced in the whole bodies of rainbow trout fry exposed to CYP. © by PSP.