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Öğe Conjunctival Impression Cytology and Tear Function in Patients with Keratoconus(2021) Özcan, Deniz Özarslan; Özcan, Sait Coşkun; Gürsoy, DidarObjectives: The aim of this study was to evaluate the ocular surface alterations of conjunctival cytological changes and tear function in patients with keratoconus. Methods: A total of 98 eyes with keratoconus and 68 eyes of age- and sex- matched healthy subjects were included in this prospective study. Ophthalmological evaluations, including Ocular Surface Disease Index (OSDI), tear break-up time (TBUT), ocular surface staining (OSS), Schirmer test, and conjunctival impression cytology (CIC), were performed. Results: The mean participant age was 23.4±5.3 years in the keratoconus group and 24.9±6.0 years in the control group. In the keratoconus group, the mean OSDI and OSS scores were statistically significantly higher than those of the controls, and the Schirmer and TBUT results were statistically significantly lower (all p<0.001). The severity of keratoconus was positively correlated with the CIC grade (r=0.292; p=0.004). Conclusion: Keratoconus results in deterioration of the ocular surface, including CIC and tear function parameters. The grade of keratoconus appears to be associated with conjunctival cytologic changes.Öğe THE EFFECT OF HISTOPATHOLOGICAL CHARACTERISTICS OF TESTICULAR TUMORS ON OVERALL SURVIVAL IN IMMIGRANTS(2022) Gökalp, Fatih; Koraş, Ömer; Gürsoy, Didar; Görür, SadıkIntroduction: Testicular cancer is a rare condition and incidence peaks in 2-3 decades. The incidence and oncological outcomes vary in patients with different race/ethnicity. In this study, we aimed to provide a description of racial difference in testicular cancer. Material and Method: Between 2016 and 2020, A total 52 patients underwent radical orchiectomy due to testicular cancer. All patients with hi stologically proven testicular germ cell tumors were included the study. Patients with other urological or systemic cancers, and lack of data were excluded from study. Results: The seminoma pathology was found in 27 patients. The median tumor size, and rete testis invasion were similar between groups (p=0.410, and p=0.487, respectively). The tumor stage was significantly higher in Immigrants (stage 2A and 3A, p<0.001) and overall survival was significantly lower in Immigrants (p<0.001). A total of 25 patients had non-seminoma pathology. The lymphovascular invasion, and tumor stage was also similar between groups (p=0.532, and p=0.781, respectively). However, overall survival was significantly lower in Immigrants (p=0.003). Conclusion: Testicular cancer is a rare but significant disease for young patients. Race/ethnicity effects oncological outcomes of testicular cancer.Öğe Effects of olive oil applied to the nonfunctional distal colon on atrophic changes in patients undergoing ostomy(İnönü Üniversitesi, 2019) Atıcı, Ahmet; Çelikkaya, Mehmet Emin; Gürsoy, DidarAim: Temporary colostomy is commonly performed for diseases requiring multi-stage surgery in pediatric surgical practice such as for anal atresia and Hirschsprung’s disease. Through this study, we aimed to decrease the diameter difference between the proximal and distal colon and subsequently provide surgical ease and to investigate the effect of 1-month application of pure olive oil, which is considered a trophic factor, to prevent distal colonic atrophy. Materials and Methods: In total, 24 pediatric patients who were treated at our clinic between June 2017 and November 2018 and who were scheduled to undergo colostomy closure were prospectively followed up. The patients were grouped into the following two groups: control group (n = 10), patients who were administered 5 cc 0.9% physiological saline solution twice a day for a month and olive oil group (n = 9), patients who were administered 5 cc pure olive oil as a trophic agent twice a day for a month. Results: There were significant differences in terms of mucosal thickness, muscular thickness, wall thickness, and colonic lumen diameter between the proximal and distal colon in the control group. On the other hand, in the olive oil group, there was no significant difference between the proximal and distal colon. However, there was a significant difference between the two groups in terms of first bowel movement and discharge times. Conclusion: Administration of olive oil from the distal colon opening prior to performing colostomy closure can decrease the diameter difference between the proximal and distal colons and provide easier surgical performance.Öğe Evaluation of Four Adult Visceral Leishmaniasis Cases(Galenos Publishing House, 2023) Çabalak, Mehmet; Çulha, Gülnaz; Kaya, Tuğba; Gürsoy, Didar; İlhan, Gül; Özbilgin, AhmetLeishmania infantum is the species responsible for visceral leishmaniasis [(VL), kala-azar], which is observed sporadically mainly in pediatric age groups in the Aegean, Mediterranean and Central Anatolian regions of Türkiye. The aim of this study is to evaluate the diagnosis, clinic, laboratory results and treatments of four adult patients with VL who applied to our hospital. The patients were referred to our hospital to investigate hematological malignancy. In the study, the data of four patients (three men, one woman; age range: 30-40 years) who were diagnosed with VL and treated in the infectious diseases clinic of our hospital between January 2022 and April 2022 were evaluated retrospectively. The diagnosis of VL was made according to appropriate clinical and physical examination findings, biochemical and serological tests (indirect fluorescent antibody test and rK39 rapid antigen test) and polymerase chain reaction (PCR) results, as well as the presence of amastigote forms of the parasite in bone marrow samples. Serology positivity was found in all patients, and bone marrow positivity was found in two patients. According to the results of RT-PCR in all patients, it was determined that the species causing the disease was L. infantum/L. donovani. Initially, the most common symptoms were fever, fatigue, and abdominal distension. None of the patients had an immunosuppressive condition. It was understood that all the patients lived in the rural area of Syria’s Idlib province. Hepatosplenomegaly, increased erythrocyte sedimentation rate, anemia, leukopenia and thrombocytopenia were found in all patients. The patients were treated with liposomal amphotericin-B (L-AMB). One patient did not come for follow-ups, the other three patients were found to have completely recovered in their follow-up. No recurrence was observed in any of the patients. In conclusion, VL should be considered in patients who apply to health institutions with complaints of fever, hepatosplenomegaly, increased erythrocyte sedimentation rate, anemia, leukopenia and thrombocytopenia. © Telif hakkı 2023 Türkiye Parazitoloji Derneği-Makale.Öğe The expression of Beta-Catenin and Sox2 in adenocarcinoma and adenomatous polyps of the colon and their association with clinicopathological parameters(2022) Güney, Neslihan; Gürses, İclal; Linke, Ebru Serinsöz; Gürsoy, Didar; Üçbilek, Enver; Çolak, TahsinObjective: Our aim was to investigate the immunohistochemical expression of ?-catenin and Sox-2 in adenomatous polyps and adenocarcinoma of colon and also to evaluate the effects of these markers in adenoma-carcinoma sequence and their association with clinicopathological parameters. Methods: Fifty-six tubular adenomas with low grade dysplasia (TALGD), 53 tubular adenomas with high grade dysplasia (TAHGD), 44 tubulovillous adenomas (TVA), 29 villous adenomas (VA) and 60 adenocarcinomas were included in the study. The nuclear staining of Sox2 was evaluated as well as both nuclear and cytoplasmic stainings of ?-catenin. A semiquantitative scoring was performed. The results were compared between the groups and the relationship of the results with clinicopathological parameters was evaluated. Results: Nuclear and cytoplasmic ?-catenin expressions of the adenocarcinomas were higher than polyps. The expressions in the VA and TVA polyp groups were higher than the expressions in TAHGD and TALGD, respectively. Membranous ?-catenin expression in the adenocarcinoma was higher than the polyps except VA. The evaluation between polyp groups with respect to membranous ?-catenin staining revealed a statistically significantly difference in favor of VA compared with TVA, TAHGD and TALGD; in favor of TAHGD compared with TVA, in favor of TVA compared with TALGD while it was found statistically significantly higher in TAHGD than TALGD. Conclusion: The results regarding ?-catenin expression of the polyp groups were consistent with the literature. There was a positive correlation between ?-catenin expression (nuclear and cytoplasmic) and malignancy. High Sox2 expressions were found correlated with malignancy potential. Large sampling size investigations to be supported by further molecular studies are needed to clarify the effect of Sox2 expression in the sequence of adenoma-carcinoma comprehensively.Öğe Hatay ilinde oral premalign lezyonların prevalansı: retrospektif bir çalışma(2020) Serindere, Gözde; Aktuna Belgin, Ceren; Gürsoy, Didar; Orhan, KaanBu çalışmanın amacı, 2017 ve 2019 yılları arasında Patoloji Anabilim Dalı'na başvuran hastalarda oral premalign lezyonların(OPL) prevalansını değerlendirmektir. Patoloji rapor arşivinde histopatolojik olarak OPL olduğu doğrulanmış toplam 194 hastageriye dönük olarak incelendi. Bunlardan 82'si (% 42,3) erkek, 112'si (% 57,7) kadındı. Cinsiyet ve yaş bilgisi tıbbi kayıtlardan eldeedildi. Patolojik sonuçlara göre OPL'ler sınıflandırıldı. 194 hastada OPL bulundu. 112 (% 57,7) kadın, 82'si (% 42,3) erkekti. Yaşdağılımına göre 10-20, 21-30, 31-40, 41-50- 51-60, 61-70, 71-80 ve 80 yaş üstü hasta sayıları 1 (% 0,5), 13 (% 6,7), 25 (% 12,9), 36(% 18,5), 50 (% 25,8), 35 (% 18,1), 20 (% 10,3) ve 14 (% 7,2) idi. En sık görülen premalign lezyon liken planus (% 50,6) olarakbulundu. Ağız boşluğunda malignite olasılığını ekarte etmek için biyopsi yapılmalıdır. OPL'lerin erken teşhisi tedavi için önemlidir.Öğe Nadir bir yerleşim : alt ekstremitede unilateral nevoid telenjiyektazi(Ayşe Akgül, 2019) Öncü, Işın Nur Sultan; Gürsoy, Didar; Serarslan, GamzeT Unilateral nevoid telenjiyektazi, ilk kez 1899 yılında Alfred Blaschko tarafından tanımlanan, dermal telenjiyektazilerle karakterize, unilateral dermatomal veya blaschkoid paternde dağılım gösteren nadir bir deri hastalığıdır. Hastalığın konjenital ve edinsel olmak üzere iki formu bulunmaktadır. Edinsel form kadınlarda, konjenital form erkeklerde daha sık görülmektedir. Sıklıkla trigeminal, servikal (C3-C5) ve üst torakal dermatom alanlarında görülmekle beraber daha nadir olarak lumbal veya sakral dermatom alanlarında da izlenebilmektedir. Bu çalışmada, lezyonların sol alt ekstremitede, lumbal ve sakral (L5-S1) dermatomlarda dağılım gösterdiği edinsel unilateral nevoid telenjiyektazi tanısı konulan, sekiz yaşındaki kız olgu sunulmuştur. Unilateral nevoid telenjiyektazinin nadir görülmesi ve bildirilen çok az sayıda alt ekstremite yerleşimli hasta bulunması nedeni ile literatür bilgileri ile birlikte tartışılması amaçlanmıştır.Öğe A rare presentation: Unilateral nevoid telangiectasia in lower extremities(OrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2019) Öncü, Işın Nur Sultan; Gürsoy, Didar; Serarslan, GamzeUnilateral nevoid telangiectasia is a rare cutaneous disease characterized by unilateral dermatomal or blaschkoid distrubution of superficial dermal telangiectasia, first described by Alfred Blaschko in 1899. Unilateral nevoid telangiectasia can be congenital or acquired. Whereas congenital forms mainly seen in men, acquired forms seen in female. It is located on the trigeminal, cervical (C3-C5) and upper thoracic dermatomes but more rarely in the lumbar or sacral dermatomes. We present an 8 years-old girl patient with a diagnosis of acquired involving left L5-S1 dermatomes. Since unilateral nevoid telangiectasia is seen rarely and very few reported cases of patients with lower extremity, it is discussed in the light of the literature data. Copyright © 2019 by Türkiye KlinikleriÖğe Renal cell carcinoma : Epidemiological profile and histopathological features(Galenos Yayınevi, 2020) Gürsoy, Didar; Seçinti, İlke EvrimObjective: Nowadays, with the use of advanced imaging methods, the incidence of renal cell carcinomas (RCCs) has increased steadily and they have become recognizable at early stage. Morphologically and immunophenotypically, RCCs are divided into many different types and are divided into three main subtypes. Each type has differences in terms of genetics, biology, and behavior. The objectives of this study is to investigate the histopathological features of tumor specimens of patients operated with diagnosis of RCC. Materials and Methods: The pathology specimens and reports of 77 patients with RCC who underwent radical or partial nephrectomy were reviewed retrospectively. Descriptive and clinical data of the patients were obtained. The size, lateralization, focality, histopathological type, Fuhrman nuclear grading system (NGS), sarcomatoid change, renal sinus and vein invasions, perirenal fat tissue invasion, hilar fatty tissue invasion, ureter surgical margin, and primary tumor stage of RCC were determined. Results: According to the histopathologic type, 77.9% of the patients had clear cell RCC, 10.4% chromophobe RCC, 9.1% papillary RCC, and 2.6% multilocular RCC. The Fuhrman NGS values were 5.2% for grade 1, 61% for grade 2, 26% for grade 3, and 7.8% for grade 4. There were sarcomatoid features in only 7.8% of the patients. There were 6 patients (7.8%) with renal sinus invasion, 3 patients (3.9%) with renal vein invasion, 8 patients (10.4%) with perirenal adipose tissue invasion, 2 patients (2.6%) with hilar fat tissue invasion, and 2 patients (2.6%) with tumors at the ureter surgical margin. Pathological changes were significantly differentiated according to gender except for the primary tumor stage. Conclusion: RCCs are divided into many different types and each type has differences in terms of genetics, biology, and behavior. Due to this, the pathologist must differentiate cell types routinely by morphology and immunohistochemical markers as well as by cytogenetic and molecular genetic analysis particularly when the cell type is equivocal.
