Renal cell carcinoma : Epidemiological profile and histopathological features
Yükleniyor...
Dosyalar
Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Galenos Yayınevi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Nowadays, with the use of advanced imaging methods, the incidence of renal cell carcinomas (RCCs) has increased steadily and they have become
recognizable at early stage. Morphologically and immunophenotypically, RCCs are divided into many different types and are divided into three main subtypes. Each
type has differences in terms of genetics, biology, and behavior. The objectives of this study is to investigate the histopathological features of tumor specimens of
patients operated with diagnosis of RCC.
Materials and Methods: The pathology specimens and reports of 77 patients with RCC who underwent radical or partial nephrectomy were reviewed
retrospectively. Descriptive and clinical data of the patients were obtained. The size, lateralization, focality, histopathological type, Fuhrman nuclear grading system
(NGS), sarcomatoid change, renal sinus and vein invasions, perirenal fat tissue invasion, hilar fatty tissue invasion, ureter surgical margin, and primary tumor stage
of RCC were determined.
Results: According to the histopathologic type, 77.9% of the patients had clear cell RCC, 10.4% chromophobe RCC, 9.1% papillary RCC, and 2.6% multilocular
RCC. The Fuhrman NGS values were 5.2% for grade 1, 61% for grade 2, 26% for grade 3, and 7.8% for grade 4. There were sarcomatoid features in only 7.8%
of the patients. There were 6 patients (7.8%) with renal sinus invasion, 3 patients (3.9%) with renal vein invasion, 8 patients (10.4%) with perirenal adipose tissue
invasion, 2 patients (2.6%) with hilar fat tissue invasion, and 2 patients (2.6%) with tumors at the ureter surgical margin. Pathological changes were significantly
differentiated according to gender except for the primary tumor stage.
Conclusion: RCCs are divided into many different types and each type has differences in terms of genetics, biology, and behavior. Due to this, the pathologist
must differentiate cell types routinely by morphology and immunohistochemical markers as well as by cytogenetic and molecular genetic analysis particularly when
the cell type is equivocal.
Açıklama
Anahtar Kelimeler
Renal cell carcinoma, Histopathology, Kidney tumors
Kaynak
Üroonkoloji Bülteni
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
19
Sayı
2
Künye
Gursoy, D., Secinti, I. E., Hakverdi, S., & Gorur, S. (2020). Renal Cell Carcinoma: Epidemiological Profile and Histopathological Features. Bulletin of Urooncology, 19(2), 68-74.
