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    ANTI-INFLAMMATORY DRUG-LOADED BIOPOLYMERIC SPONGIOUS MATRICES WITH THERAPEUTIC PERSPECTIVES IN BURNS TREATMENT
    (Soc Stinte Farmaceutice Romania, 2018) Udeanu, Denisa Ioana; Kaya, Madalina Georgiana Albu; Ghica, Mihaela Violeta; Marin, Stefania; Marin, Maria Minodora; Kaya, Durmus Alpaslan; Popa, Lacramioara
    The most important goals of burns treatment suppose a fast skin regeneration to promote healing, the initial pain reduction and minimal scars forming. The development of new biopolymers-based wound dressings to ensure a proper healing process is nowadays a major challenge considering the incidence and consequences of burns. Our previously designed anti-inflammatory drug-loaded biopolymeric spongious matrices were initially tested by in vitro analysis and revealed proper morphological structure, swelling ability, degradation profiles and drug release patterns, indicating their potential use for burns treatment. Thus, the study aims to evaluate some collagen-sodium carboxymethylcellulose spongious matrices with or without mefenamic acid as non-steroidal anti-inflammatory drug in experimentally induced burns on Wistar rats, a frequently used animal model for the assessment of wounds healing. The treatment with the designed sponges promoted the wound healing compared to the classical treated control group. The sponges with mefenamic acid accelerated the healing process with a faster epithelial regeneration and a minimal scarring in comparison with the formulations containing no anti-inflammatory drug.
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    DICLOFENAC SPONGIOUS MATRICES BASED ON COLLAGEN AND ALGINATE FOR RELIEVING INJURY PAINS
    (Incdtp-Icpi, 2018) Draghici, Roxana-Denisa; Marin, Maria Minodora; Ghica, Mihaela Violeta; Kaya, Madalina Georgiana Albu; Anuta, Valentina; Dinu-Pirvu, Cristina; Kaya, Durmus Alpaslan
    The sport injuries become more and more frequent so there is a need to discover new solutions for increasing the quality of life for people affected by such wounds. The aim of this study was to obtain a novel NSAID drug delivery system, topical diclofenac spongious matrices based on collagen and alginate for the treatment of injuries and relieving of pain. The samples were analyzed by flow analysis and after their freeze-drying were analyzed by FT-IR and in vitro release of sodium diclofenac.The results obtained from analyses confirmed that diclofenac spongious matrices based on collagen and alginate exhibit proper characteristics for the treatment of injuries and relieving of pain.
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    Doxycycline/collagen/chondroitin sulfate delivery systems used for cartilage regeneration
    (Inst. Nat. Cercetare-Dezvoltare Text. Pielarie, 2020) Marin, Maria-Minodora; Albu Kaya, M?d?lina Georgiana; Ghica, Mihaela Violeta; D?nil?, Elena; Coar?, Gheorghe; Popa, L?cr?mioara; Chelaru, Ciprian
    Cartilage damage is difficult to self-heal due to an avascular microenvironment and distinct mechanical properties. These features are a challenge in designing a cartilaginous tissue with repairing effect without producing any local infections. Thus, a biodegradable scaffold in which the drug can be incorporated is preferable. Drug delivery systems based on collagen sponges have progressively become remarkable biomaterials for different medical applications. The aim of this work was to design and characterize some collagen/chondroitin sulfate supports with doxycycline for cartilage tissue regeneration. The doxycycline should prevent the development of potential infections. Collagen, chondroitin sulfate and doxycycline gels were cross-linked with different concentrations of glutaraldehyde and then freeze-dried in order to obtain collagen matrices. The structural characteristics for the new synthesized biomaterials were firstly assessed by infrared spectroscopy (FT-IR), and scaffolds morphology was then evaluated by optical microscopy and water uptake. The enzymatic biodegradation was also performed. Also, the sponges surface properties were quantified through contact angle. The in vitro doxycycline kinetics release was performed with a dissolution equipment and the release mechanism was investigated. The obtained results recommend these new scaffolds based on doxycycline/collagen/chondroitin sulfate as a promising approach for the treatment of cartilage problems. © 2020 Toate drepturile asupra acestei edi?ii sunt rezervate editorilor.
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    The effect of lavandula essential oils on release of niflumic acid from collagen hydrolysates
    (Korean Institute Chemical Engineers, 2016) Ghica, Mihaela Violeta; Albu, Madalina Georgiana; Kaya, Durmus Alpaslan; Popa, Lacramioara; Ozturk, Sevket; Rusu, Laura-Cristina; Dinu-Pirvu, Cristina
    The aim of this paper is to design and characterize some drug delivery systems (DDS) based on collagen hydrolysates (H), niflumic acid as a non-steroidal anti-inflammatory model drug and two essential oils of Lavandula officinalis L. (LO) and Lavandula stoechas L. subsp. Stoechas (LS), for use in healing cutaneous wounds with post-lesion inflammatory response. The essential oils are characterized by GC-MS. The wettability capacity of collagen hydrolysate powders was assessed by contact angle measurement. Niflumic acid release was investigated using a modified Franz diffusion cell, and the diffusion coefficient, time-lag and drug flux were determined. The kinetic parameters were found to be influenced by different concentrations and types of essential oils. These therapeutical products, based on collagen hydrolysates and synergistic drug associations, could have potential biomedical application in wound healing treatment.
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    Formulation and characterization of anti?aging cosmetic emulsions based on collagen hydrolysate and caffeine
    (Inst. Nat. Cercetare-Dezvoltare Text. Pielarie, 2020) D?nil?, Elena; Albu Kaya, M?d?lina Georgiana; Ghica, Mihaela Violeta; Bunea, Ana-Maria; Popa, L?cr?mioara; Kaya, Durmu? Alpaslan; Öztürk, Şevket
    The goal of this work was to formulate and characterize some O/W emulsions, designed as skin anti-aging creams. The cosmetic formulations based on collagen hydrolysate, caffeine and natural ingredients (essential and vegetable oils) were evaluated organoleptically, in terms of pH, morphological, superficial and rheological properties. The rheological measurements were carried out at 23 and 32°C, and the shear stress versus shear rate ascending and descending rheograms were built, as well as the flow patterns viscosity versus shear rate. All emulsions obtained are stable at different temperatures and the pH values correspond to the skin physiological one, indicating that cosmeceuticals can be safely applied to the skin. Results from the optical microscopy analysis show that all emulsions presented a creamy and foamy appearance. The superficial profiles, quantified through contact angle at solid/liquid interface, indicated a high emulsions hydrophilicity degree. The emulsions showed a pseudoplastic and thixotropic behaviour, facilitating the flow formulations and the topical application. The flow properties were quantified according to the Power law model, and the thixotropic analysis was performed using specific descriptors as thixotropic area and thixotropic index. The designed emulsions presented physico-chemical properties adequate for cosmetic skin care product formulations. © 2020 Toate drepturile asupra acestei edi?ii sunt rezervate editorilor.
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    Rheological Properties and Stability of Dermatocosmetic Emulsions with Collagen and Natural Ingredients Used as Color Correcting Cream and Cream Foundation
    (Revista Chimie Srl, 2019) Danila, Elena; Kaya, Durmus Alpaslan; Ghica, Mihaela Violeta; Kaya, Madalina Georgiana Albu; Negrea, Cristina; Popa, Lacramioara; Nitipir, Cornelia
    The aim of this study was to formulate and evaluate two types of 0/W emulsions based on collagen and other natural ingredients that can be used as color correcting (CC-cream) and cream foundation. Both types of emulsions obtained are stable at different temperatures and the pH values of emulsions correspond to the natural pH of the skin, indicating that emulsions can be safely applied to the skin. Results from the optical microscopy analysis show that all emulsions present foam-like appearance. The rheological properties of emulsions were studied and it was proved that all emulsions present a non-Newtonian pseudoplastic behaviour and thixotropic characteristics at two operating temperatures (24 and 33 degrees C). It can be concluded that all emulsions can be used as a natural alternative to a CC-cream or a cream foundation. Further microbiological tests and clinical trials are necessary for the obtained emulsions.
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    Rheological properties and stability of dermatocosmetic emulsions with collagen and natural ingredients used as color correcting cream and cream foundation
    (Syscom 18 SRL, 2019) Danila, Elena; Kaya, Durmus Alpaslan; Ghica, Mihaela Violeta; Kaya, Madalina Georgiana Albu; Negrea, Cristina; Popa, Lacramioara; Nitipir, Cornelia
    The aim of this study was to formulate and evaluate two types of O/W emulsions based on collagen and other natural ingredients that can be used as color correcting (CC-cream) and cream foundation. Both types of emulsions obtained are stable at different temperatures and the pH values of emulsions correspond to the natural pH of the skin, indicating that emulsions can be safely applied to the skin. Results from the optical microscopy analysis show that all emulsions present foam-like appearance. The rheological properties of emulsions were studied and it was proved that all emulsions present a non-Newtonian pseudoplastic behaviour and thixotropic characteristics at two operating temperatures (24 and 33°C). It can be concluded that all emulsions can be used as a natural alternative to a CC-cream or a cream foundation. Further microbiological tests and clinical trials are necessary for the obtained emulsions. © 2019 SYSCOM 18 S.R.L.. All rights reserved.
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    Selection of Optimal Operating Conditions for Extraction of Myrtus Communis L. Essential Oil by the Steam Distillation Method
    (Mdpi, 2020) Kaya, Durmus Alpaslan; Ghica, Mihaela Violeta; Danila, Elena; Ozturk, Sevket; Turkmen, Musa; Albu Kaya, Madalina Georgiana; Dinu-Pirvu, Cristina-Elena
    Myrtus communis L. is one of the important aromatic and medicinal species from the Mediterranean area. It is used in various fields such as culinary, cosmetic, pharmaceutical, therapeutic, and industrial applications. Thus, a Box-Wilson experimental plan was used in this study to select the optimal operating conditions in order to obtain high volumes of essential oils. The factorial design method was applied to evaluate at an industrial scale the effect of major process variables on the essential oil extraction from Myrtus communis L. herbs by the steam distillation method. The input variables considered as significant operating conditions were: X-1-boiler occupancy rate (boilers were filled to 50%, 75%, and 100%), X-2-distillation duration (distillation was continued 60, 75, and 90 min), and X-3-particle size (herbs were cut in sizes of 10, 20, and 30 mm via guillotine). The dependent variable selected, coded as Y, was the essential oil volume obtained (mL). The steps of the classical statistical experimental design technique were complemented with the Taguchi method to improve the extraction efficacy of essential oil from Myrtus communis L., and the optimum parameter conditions were selected: boiler occupancy rate 100%, distillation duration 75 min, and particle size 20 mm. Following the optimum parameters, the GC-MS assay revealed for the Myrtus communis L. essential oil two predominant components, alpha -pinene-33.14% and eucalyptol-55.09%.