Yazar "Gozukara, Kerem Han" seçeneğine göre listele

Listeleniyor 1 - 5 / 5
  • Küçük Resim
    Öğe
    The effect of Bongardia Chrysogonum on prostate tissue in a rat model of STZ-induced diabetes
    (Springer International Publishing Ag, 2016) Dokuyucu, Recep; Gozukara, Kerem Han; Ozcan, Oguzhan; Sefil, Nebihat Kaplan; Nacar, Ahmet; Dokuyucu, Ahmet; Inci, Mehmet
    Background: Bongardia chrysogonum is widely used in Turkey for treating urinary tract infections and prostate hypertrophy, and it also has potent hypoglycemic effects and aids glucose homeostasis. Because of the inflammatory conditions in diabetes mellitus (DM), the prostate tissue of men with diabetes is particularly susceptible to developing hypoplasia, and DM produces characteristic pathological changes in prostate tissue. Here, we examined the effects of B. chrysogonum on the prostate tissue of rats with streptozotocin (STZ)-induced diabetes. Results: The glucose levels were statistically significantly higher in the diabetic rats than in healthy controls (P < 0.001). Further, they were significantly lower in the healthy and diabetic rats administered B. chrysogonum than in the untreated diabetic rats (P < 0.001 and 0.05, respectively). The total cholesterol levels were significantly lower in the healthy rats administered B. chrysogonum than the healthy controls (P < 0.05) and diabetic rats (P < 0.01). They were also significantly lower in the diabetic rats administered B. chrysogonum than those that were left untreated (P < 0.05). The testosterone levels were significantly lower in the untreated diabetic rats than in the controls (untreated ones and those administered B. chrysogonum) and diabetic rats administered the herb (P < 0.001, 0.05 and 0.01, respectively). The oxidative stress index was significantly higher in the untreated diabetic rats than the healthy controls (P < 0.05). It was also significantly lower in the healthy and diabetic groups treated with B. chrysogonum than the untreated diabetic rats (P < 0.05). Histological examination showed no changes in the prostate tissue of the non-diabetic rats. In the diabetic group, the glandular lumens were filled with cellular debris and leucocytic infiltrate, and the glandular epithelium was degenerated and thickened. In the diabetic group treated with B. chrysogonum, the epithelium was better preserved and less debris was seen in the glandular lumen. Conclusion: To our knowledge, this is the first study to histologically prove the effects of B. chrysogonum on prostate tissue in diabetes. Our findings may be useful in developing B. chrysogonum into a therapeutic agent against diabetes and benign prostate hyperplasia.
  • Küçük Resim
    Öğe
    Glomerular hyperfiltration in hypogonadotropic hypogonadic patients: Overlooking a cache?
    (Springer, 2015) Gozukara, Kerem Han; Arslan, Abdulmuttalip; Gorur, Sadik; Rifaioglu, Mehmet Murat; Carlioglu, Ayse
    To investigate renal function in idiopathic hypogonadotropic hypogonadic (IHH) patients by measuring glomerular filtration rate (GFR) using modification of diet in renal disease formula, and determine whether there is any relationship between GFR and testosterone levels. Thirty-three patients with IHH and 37 healthy control subjects participated in this study. The IHH group showed statistically significant higher GFR and proteinuria with respect to the control group (163.1 +/- A 46.9 to 117.9 +/- A 30.5 mL/min, p < 0.001; 0.2 +/- A 0.1 to 0.08 +/- A 0.02 mg/dL, p = 0.041, respectively). Uric acid and creatinine levels were statistically lower than in the control group (4.6 +/- A 0.5-3.6 +/- A 0.9 mg/dL, p = 0.02; 0.7 +/- A 0.2 to 0.9 +/- A 0.2 mg/dL, p < 0.001, respectively). Hyperfiltration positively correlated with IHH in multivariate linear regression analyses (beta = 0.591, p < 0.001). In addition, in the IHH group, we found that the GFR increased independently of body mass index and age. Our study confirms that low testosterone in IHH patients is associated with glomerular hyperfiltration. Patients with IHH should be carefully monitored with respect to their GFR.
  • Küçük Resim
    Öğe
    The Investigation of Relationship between Coronary Artery Ectasia, Benign Prostatic Enlargement, and Lower Urinary Tract Symptoms
    (Elsevier Science Inc, 2015) Inci, Mehmet; Baydilli, Numan; Akcay, Adnan Burak; Demirtas, Abdullah; Rifaioglu, Mehmet Murat; Gozukara, Kerem Han; Kaya, Mehmet Gungor
    OBJECTIVE To investigate benign prostatic enlargement (BPE) and lower urinary tract symptoms (LUTS) in patients with coronary artery ectasia (CAE). The relation between CAE, BPE, and LUTS has not been studied so far. METHODS We investigated BPE and LUTS symptoms in 47 men with CAE, 45 men with coronary artery disease (CAD), and 47 male controls with normal coronary arteries. LUTS was evaluated by the International Prostate Symptom Score (IPSS). BPE was evaluated with transabdominal ultrasonography. CAD was defined as myocardial infarction and angiographically diagnosed coronary disease. CAE was defined as being without any stenotic lesions with a visual assessment of the coronary arteries showing a luminal dilatation >= 1.5 fold of the adjacent normal coronary segments. RESULTS Prostate volume was higher in CAE and CAD patients compared with that of the control subjects, respectively (41.0 +/- 10.4 vs 33.5 +/- 9.4 cm(3); 39.1 +/- 10.3 vs 33.5 +/- 9.4 cm3; P = .0001); total IPSS was higher in CAD and CAE patients compared with that of the control subjects (P = .0001). Postmictional residual urine volume was higher in CAE and CAD patients compared with that of the control subjects (P = .002). CONCLUSION We showed that patients with CAE have higher prostate volume, IPSS, and postmictional residual urine volume compared with those of controls with normal coronary angiograms. This study proposes that BPE, LUTS, and CAE maybe different disorders to a common vascular pathology and endothelial dysfunction. This study showed that BPE and LUTS were frequently seen in CAE at least as much as in CAD. Therefore, LUTS and BPE should be kept in mind for CAE patients in follow-ups. (C) 2015 Elsevier Inc.
  • Küçük Resim
    Öğe
    Protective Effects of Colchicine on Testicular Torsion/Detorsion-Induced Ischemia/Reperfusion Injury in Rats
    (Urol & Nephrol Res Ctr-Unrc, 2020) Gozukara, Kerem Han; Ozcan, Oguzhan; Ozgur, Tumay; Kaya, Yusuf Selim; Tutuk, Okan
    Purpose: To evaluate the short-term use of colchicine on preventing ischemia-reperfusion injury after surgery in an experimental animal model. Materials and Methods: A total of 40 rats were divided into five groups (n = 8). Sham (Sh), ischemia-reperfusion (I/R), I/R and colchicine-treated for once per-operatively (I/Rcl), I/R and colchicine-treated for 5 days postoperatively (I/Rc5), and I/R and placebo given for 5 days (I/Rp) groups. Testicular torsion was created by rotating the testicle 720o in clockwise direction and held for 3 hours. In group I/Rcl 30 minutes before detorsion, p.o. 1 mg/kg mL infusion of colchicine was given only once. In group I/Rc5, colchicine continued p.o. once daily for five days. Tissue malonyldialdehite (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) were measured for evaluating the oxidative stress. Apoptosis levels shown with Caspase-3 staining and mean seminiferous tubular diameter (MSTD), germinal epithelial cell thickness (GECT), and mean testicular biopsy score (MTBS) were used to evaluate the germ cell damage. Results: Decreased protein MDA levels therewithal increased SOD, CAT and GPx levels achieved in I/Rc5 group when compared to I/R group and did not differ from the I/Rp group (p < 0.05). MSTD, GECT, and JS were better in I/Rc5 than I/Rp which showed the natural course of I/R damage in testis (p < 0.005). Caspase 3 positivity, as an apoptosis indicator, were significantly lower (p < 0.05) in I/Rc5 group in comparison with I/R, I/Rcl, and I/Rp groups. Conclusion: The usage of colchicine as a complementary treatment after definitive surgery reduce early-onset ischemia-reperfusion damage and diminishes apoptosis.
  • Küçük Resim
    Öğe
    Venous involvement in sickle cell diseases
    (E-Century Publishing Corp, 2016) Helvaci, Mehmet Rami; Gokce, Cumali; Sahan, Mustafa; Hakimoglu, Sedat; Coskun, Mesut; Gozukara, Kerem Han
    Background: Sickle cell diseases (SCDs) cause an accelerated atherosclerotic process in whole body. We tried to understand whether or not there is an additional venous involvement in the SCDs. Methods: As one of the significant endpoints of the SCDs, cases with chronic obstructive pulmonary disease (COPD) and without were collected into the two groups. Results: The study included 427 patients (220 males). There were 71 patients (16.6%) with COPD. Mean age of patients was significantly higher in the COPD group (32.8 versus 29.8 years, P=0.005). The male ratio was significantly higher in the COPD group, too (78.8% versus 46.0%, P<0.001). Smoking (35.2% versus 11.2%, P<0.001) and alcohol (7.0% versus 1.9%, P<0.01) were also higher among the COPD cases. Beside these, priapism (14.0% versus 2.8%, P<0.001), cirrhosis (8.4% versus 3.3%, P<0.05), leg ulcers (23.9% versus 12.0%, P<0.01), digital clubbing (25.3% versus 6.7%, P<0.001), coronary heart disease (23.9% versus 13.7%, P<0.05), chronic renal disease (15.4% versus 7.0%, P<0.01), and stroke (16.9% versus 8.1%, P<0.01) were all higher among the COPD cases. Although deep venous thrombosis and/or varices and/or telangiectasias of the lower limbs were also higher among them, the difference was nonsignificant (11.2% versus 5.0%, P>0.05) probably due to small sample size of the COPD group. Conclusion: SCDs are chronic catastrophic processes on vascular endothelium particularly at the capillary level, and terminate with accelerated atherosclerosis induced end-organ failures in early years of life. Beside the accelerated atherosclerotic process, venous involvement may also be common in the SCDs.