Venous involvement in sickle cell diseases
[ N/A ]
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
E-Century Publishing Corp
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: Sickle cell diseases (SCDs) cause an accelerated atherosclerotic process in whole body. We tried to understand whether or not there is an additional venous involvement in the SCDs. Methods: As one of the significant endpoints of the SCDs, cases with chronic obstructive pulmonary disease (COPD) and without were collected into the two groups. Results: The study included 427 patients (220 males). There were 71 patients (16.6%) with COPD. Mean age of patients was significantly higher in the COPD group (32.8 versus 29.8 years, P=0.005). The male ratio was significantly higher in the COPD group, too (78.8% versus 46.0%, P<0.001). Smoking (35.2% versus 11.2%, P<0.001) and alcohol (7.0% versus 1.9%, P<0.01) were also higher among the COPD cases. Beside these, priapism (14.0% versus 2.8%, P<0.001), cirrhosis (8.4% versus 3.3%, P<0.05), leg ulcers (23.9% versus 12.0%, P<0.01), digital clubbing (25.3% versus 6.7%, P<0.001), coronary heart disease (23.9% versus 13.7%, P<0.05), chronic renal disease (15.4% versus 7.0%, P<0.01), and stroke (16.9% versus 8.1%, P<0.01) were all higher among the COPD cases. Although deep venous thrombosis and/or varices and/or telangiectasias of the lower limbs were also higher among them, the difference was nonsignificant (11.2% versus 5.0%, P>0.05) probably due to small sample size of the COPD group. Conclusion: SCDs are chronic catastrophic processes on vascular endothelium particularly at the capillary level, and terminate with accelerated atherosclerosis induced end-organ failures in early years of life. Beside the accelerated atherosclerotic process, venous involvement may also be common in the SCDs.
Açıklama
Anahtar Kelimeler
Sickle cell diseases, chronic endothelial damage, deep venous thrombosis, varice, telangiectasia
Kaynak
International Journal of Clinical and Experimental Medicine
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
9
Sayı
6
