Venous involvement in sickle cell diseases

Basit Öğe Kaydı
dc.authoridhakimoglu, sedat/0000-0002-1556-7996
dc.contributor.authorHelvaci, Mehmet Rami
dc.contributor.authorGokce, Cumali
dc.contributor.authorSahan, Mustafa
dc.contributor.authorHakimoglu, Sedat
dc.contributor.authorCoskun, Mesut
dc.contributor.authorGozukara, Kerem Han
dc.date.accessioned2024-09-18T20:57:01Z
dc.date.available2024-09-18T20:57:01Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Sickle cell diseases (SCDs) cause an accelerated atherosclerotic process in whole body. We tried to understand whether or not there is an additional venous involvement in the SCDs. Methods: As one of the significant endpoints of the SCDs, cases with chronic obstructive pulmonary disease (COPD) and without were collected into the two groups. Results: The study included 427 patients (220 males). There were 71 patients (16.6%) with COPD. Mean age of patients was significantly higher in the COPD group (32.8 versus 29.8 years, P=0.005). The male ratio was significantly higher in the COPD group, too (78.8% versus 46.0%, P<0.001). Smoking (35.2% versus 11.2%, P<0.001) and alcohol (7.0% versus 1.9%, P<0.01) were also higher among the COPD cases. Beside these, priapism (14.0% versus 2.8%, P<0.001), cirrhosis (8.4% versus 3.3%, P<0.05), leg ulcers (23.9% versus 12.0%, P<0.01), digital clubbing (25.3% versus 6.7%, P<0.001), coronary heart disease (23.9% versus 13.7%, P<0.05), chronic renal disease (15.4% versus 7.0%, P<0.01), and stroke (16.9% versus 8.1%, P<0.01) were all higher among the COPD cases. Although deep venous thrombosis and/or varices and/or telangiectasias of the lower limbs were also higher among them, the difference was nonsignificant (11.2% versus 5.0%, P>0.05) probably due to small sample size of the COPD group. Conclusion: SCDs are chronic catastrophic processes on vascular endothelium particularly at the capillary level, and terminate with accelerated atherosclerosis induced end-organ failures in early years of life. Beside the accelerated atherosclerotic process, venous involvement may also be common in the SCDs.en_US
dc.identifier.endpage11957en_US
dc.identifier.issn1940-5901
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-84977597305en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage11950en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12247
dc.identifier.volume9en_US
dc.identifier.wosWOS:000379157300146en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSickle cell diseasesen_US
dc.subjectchronic endothelial damageen_US
dc.subjectdeep venous thrombosisen_US
dc.subjectvariceen_US
dc.subjecttelangiectasiaen_US
dc.titleVenous involvement in sickle cell diseasesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu