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Öğe Clinical efficacy of diclofenac sodium and flunixin meglumine as adjuncts to antibacterial treatment of respiratory disease of calves(Wiley-Blackwell, 2010) Guzel, M.; Karakurum, M. C.; Durgut, R.; Mamak, N.Objective To compare the efficacy of the non-steroidal antiinflammatory drugs, diclofenac sodium and flunixin meglumine as adjuncts to the antibiotic treatment of bovine respiratory disease (BRD). Procedure We randomly allocated 80 Holstein calves with BRD to three groups. All the calves received a dose of 2.5 mg/kg tulathromycin by single subcutaneous injection and two of the groups received, in addition, either 2.5 mg/kg diclofenac sodium as a single intramuscular injection (diclofenac group, n = 30) or 2.2 mg/kg flunixin meglumine as an intravenous injection on the first three consecutive days after tulathromycin administration (flunixin group, n = 30). All calves were given a clinical score prior to initial treatment (day 0) and after treatment (days 1, 2, 3, 7 and 14) by observing appetite, demeanour, rectal temperature, the rate and type of respiration, presence or absence of coughing, and nasal discharge. Results During the first 48 h, improvement of adverse signs of respiratory disease, such as pyrexia and elevated respiratory rate, and of a high clinical index score was significant in the two adjunct groups compared with the calves receiving antibiotic alone. The reduction in pyrexia was greatest in the diclofenac group. There were no statically significant differences between treatment groups with regard to eventual perceived recovery from respiratory disease in 14 days. Conclusion In this trial, a single intramuscular dose of diclofenac sodium was equally effective as three intravenous injections of flunixin meglumine given on consecutive days as adjunctive therapy for BRD.Öğe Corynebacterium pseudotuberculosis infection in Saanen x Kilis crossbred (White) goats in Ankara, Turkey and effective kanamycin treatment(Elsevier Science Bv, 2008) Ural, K.; Alic, D.; Haydardedeoglu, A. E.; Cedden, F.; Guzel, M.; Ozyildiz, Z.; Cantekin, Z.In the present paper we describe Corynebacterium pseudotuberculosis infection in the Saanen x Kilis crossbred goats with abscesses located in retropharyngeal (n=29), mandibular (n=49), parotid (n=26), superficial cervical (n=40), subiliac (n=23) and popliteal (n=11) lymph nodes. The most prominent site of the abscesses was in the anterior half of the body affecting 80.89% of the goats. Histopathological examination of the lymph nodes showed pyogranulomatous inflammation. The goats were randomly assigned to either kanamycin treatment group or a placebo. The efficacy of kanamycin was assessed clinically and on the basis of a lesion score derived from the examination of the affected lymph nodes. Clinical evaluations and lesion scoring were done by the same veterinary investigator. Both owners and the veterinary investigator were blinded to the allocation to the groups. Throughout the study kanamycin treatment significantly decreased (P < 0.05) the investigator's clinical scores while no significant changes were detected in the placebo group. (c) 2008 Elsevier B.V. All rights reserved.Öğe Detection and Sequence Analysis of Equine Gammaherpesviruses from Horses with Respiratory Tract Disease in Turkey(Wiley, 2010) Ataseven, V. S.; Bilge-Dagalp, S.; Oguzoglu, T. C.; Karapinar, Z.; Guzel, M.; Tan, M. T.P>The equid herpesvirus 2 (EHV-2) and 5 (EHV-5), identified agents of respiratory infections and keratoconjunctivitis cases in some equids, comprise a high degree of antigenic heterogeneity. Prevalence and genetic characterization of EHV-2 and EHV-5 strains from Turkey were investigated in this study. A total of 73 nasal swabs and 54 blood specimens were sampled from horses with respiratory tract diseases characterized by mucopurulent nasal discharge and occasional coughing. Overall, EHV-2- and EHV-5-specific DNA amplicons were obtained from 19.2% (14/73) and 21.9% (16/73) of horses tested by multiplex nested PCR. Sequences of EHV-2 and EHV-5 glycoprotein B (gB) gene were used in a phylogenetic analysis that included six EHV-2 and three EHV-5 isolates, which showed that the Turkish EHV-2 and EHV-5 strains have marked sequence divergence from European strains and from each other. Turkish EHV-2 isolates were divided into two distinct subdivisions, and a few isolates were located on a separate branch. This study provides the first epidemiological and phylogenetical report about EHV-2 and EHV-5 infections in Turkey.Öğe Detection of Echinococcus granulosus coproantigens in dogs from Antakya Province, Turkey(Walter De Gruyter Gmbh, 2008) Guzel, M.; Yaman, M.; Koltas, I. S.; Demirkazik, M.; Aktas, H.Seventy-nine owned dogs (47 males and 32 females) from Antakya province were examined for E. granulosus by coproantigen ELISA (CHEKIT (R)-ECHINOTEST) between April to July in 2006. The estimated prevalence of E. granulosus infection was 8.86 % (7/79). Mean age of the dogs with E. granulosus was 2.3 years ranging from one to five years. There was no statistically significant difference regarding the prevalence between male and female dogs. A significant difference was detected between unrestrained (or free roaming) and indoor or chained dogs (p < 0.05). Although the prevalence of the E. granulosus infection in owned dogs in Antakya province is low, the incidence was quite high in the unrestrained and undewormed dogs. Therefore a preventive control programme in the dogs should be initiated in this region.Öğe Evaluation of ivermectin tablets in the treatment of generalized canine demodicosis(Ecole Nationale Veterinaire Toulouse, 2007) Karakurum, M. C.; Ural, K.; Cingi, C. C.; Guzel, M.; Haydardedeoglu, A. E.; Borku, M. K.Sixteen privately owned dogs with generalized demodicosis included in this study. For the treatment of generalized demodicosis, tablet form of ivermectin (Efektin tablet (R) 10 mg, Sanovel) at a dose of 600 mu g kg(-1) daily was used in study dogs for 6-22 weeks. lvermectin was used at least for 2 weeks more after no mites (dead or alive) seen. All dogs had significant reduction in the in clinical signs and number of mites on skin scrapings during re-evaluations. All dogs became skin scrapings negative. After no mites were seen, treatment was continued for 2 more weeks and then stopped. But three dogs relapsed 5, 8 and 9 months after the therapy lasted. Remained 13 dogs were negative for skin scrapings and clinically normal after 12 months. Oral ivermectin, at a dosage of 600 mu g kg(-1), PO, daily, was found to be effective in resolving generalized demodicosis in 13 of 16 dogs (82,25%.) in one year follow-up after discontinuing of therapy. Although, there were some literatures evaluating the efficacy of the use of injectable formula of ivermectin, to the present authors' knowledge these is the first report evaluating tablet form of ivermectin in the treatment of canine demodicosis.Öğe Evaluation of the hormones responsible for the gastrointestinal motility in cattle with displacement of the abomasum; ghrelin, motilin and gastrin(Bmj Publishing Group, 2013) Ozturk, A. S.; Guzel, M.; Askar, T. K.; Aytekin, I.This study provides the evidence of increased serum gastrointestinal motility hormone concentrations including ghrelin, motilin and gastrin in cattle with displacement of abomasum (DA). In this study, 38 cows with DA (21 left DA (LDA) and 17 right DA (RDA)) and 15 healthy controls were included. All cattle with DA were at the stage of postpartum one to eight weeks, and had clinical signs including anorexia, decreased milk yield and scanty, pasty faeces. Serum ghrelin, motilin and gastrin concentrations, and leptin concentration which is a functional antagonist of ghrelin, were determined by ELISA. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), Na, K, Cl, Ca and P concentrations were measured by spectrophotometer. In serum biochemical analysis, increases were seen on the serum ALT, AST and GGT activities; however, serum Na, K, Cl and P concentrations decreased in abomasal displacement compared with the control animals. The serum ghrelin, motilin and gastrin concentrations increased in the cattle with LDA and RDA, as compared with those in the healthy controls. On the other hand, serum leptin concentration decreased in the cattle with DA compared with the controls. Increases in the serum ghrelin, motilin and gastrin concentrations might be attributed to activation of gastrointestinal motility hormones to enhance of gastric emptying in impaired gastric motility and/or outlet occlusion in displaced abomasum.Öğe Frequencies of blood type A, B and AB in cats from the mediterranean sea coast of the Turkey(Ecole Nationale Veterinaire Toulouse, 2010) Arikan, S.; Guzel, M.; Ozturk, A. S.; Simsek, O.The aim of the present study was to determine the frequency of blood types in cats located in southern Turkey and the inherent risk of isoerythrolysis in kittens born to parents of unknown blood type. A total of 240 non-pedigree cats stemming from 6 cities of the Mediterranean Sea cost were blood typed by slide agglutination assays: the type A was assessed using an anti-A antiserum prepared from known type B cats, while the type B was determined using the lectin from Triticum vulgaris, then the proportions of mating carrying a risk for neonatal isoerythrolysis were calculated. The overall proportions of type A, type B and type AB were 72.1%, 25.4% and 2.5% respectively and the specific prevalence of these blood types were relatively homogeneous among the 6 cites. Considering that all type B cats possess high serum titre of anti-A antibodies, the calculated mean risk for neonatal isoerythrolysis was high (18.9%), ranged from 9.9% to 22.0% according to the cities. These results clearly demonstrate that not-typed transfusion or mating between unknown blood type cats carries a high risk for incompatibility reactions because of the relatively high type B prevalence and lead to strong recommendation for blood typing cats.Öğe Frequency of blood types DEA 1.1, 3, 4, 5, and 7 in Kangal dog(Ecole Nationale Veterinaire Toulouse, 2009) Arikan, S.; Guzel, M.; Mamak, N.; Ograk, Y. Z.Despite clinical significance of the blood typing, relatively little is known about the prevalence of canine blood groups. This study aimed to determine the frequency of blood types DEA 1.1, 4, 5. and 7 in Kangal dogs, a Turkish shepherd dog. A total of 198 Kangal dogs were surveyed from local government organizations and private breeders living around Kangal town of Sivas province in Eastern Turkey. Blood typing was performed using tube agglutination assay. Of the 198 dogs, 61.1% had DEA 1.1 positive reactions. Approximately one fourth of dogs (232%) were positive for DEA 3. All dogs (100%) were positive for DEA 4. Prevalence of DEA 5 and 7 positive dots wits 55.5% and 71.7% respectively. The most common blood type, were DEA 1.1, 4 and 7. DEA 4 does not seem to be important for Kangal dogs in terms of transfusion medicine, since all dots have DEA 4 positivity. The prevalence and antigenic properties of DEA 1.1 and 7 are significantly high, which might create acute hemolytic transfusion reactions if unmatched transfusion is performed in Turkish Kangal dogs.Öğe Incidence of failure of immune passive transfer (FPT) in thoroughbred foals - Interest of a rapid diagnosis for FPT(2005) Kalinbacak, A.; Guzel, M.; Altintas, I.The occurrence of complete or partial failure of passive transfer of colostral immunoglobulin to newborns induces low blood IgG concentrations in foals and renders them highly sensitive to infectious diseases. This prospective study was conducted on 190 thoroughbred newborn foals from a breeding farm in Turkey by determining blood IgG concentrations using a rapid, semi-quantitative test, the Snap Foal IgG test. The FPT incidence was 17.4% : 6.3% of foals presented total FPT with blood IgG concentrations below 4 g/L and 11.1% presented partial FPT with blood IgG concentrations between 4 and 8 g/L. Because of the precocious FPT diagnosis, colostrum could be orally administered for correcting foal immune status in a first attempt. Consequently, equine plasma perfusion has been reserved only for foals resistant to colostrum treatment.Öğe Nimesulide-induced acute biliary tract injury and renal failure in a kitten: a case report(Czech Academy Agricultural Sciences, 2008) Borku, M. K.; Guzel, M.; Karakurum, M. C.; Ural, K.; Aktas, S.A 3-month-old male kitten was presented to our clinic with malaise, vomiting and jaundice. In the anamnesis, we learned that the cat had a history of anorexia, sneezing, and nasal discharge and that the owner had administered 100 mg/day (t.i.d.) nimesulide orally for three days. In the laboratory study, high levels of serum alkaline phosphatase, gamma-glutamyl transtransferase, total bilirubin, direct bilirubin, indirect bilirubin, urea, and creatinine were detected. All the clinical signs and laboratory abnormalities returned to normal levels after cessation of the nimesulide and supportive treatment. In this case, clinical and laboratory findings were thought to be compatible with nimesulide-induced acute biliary injury and renal failure. This case report indicates that the household pets are at risk of toxic drugs administered by their owners and great caution should be taken in administering NSAIDs in cats.Öğe Prevalence of Dirofilaria immitis in dogs from Hatay province, Turkey(Cambridge Univ Press, 2009) Yaman, M.; Guzel, M.; Koltas, I. S.; Demirkazik, M.; Aktas, H.The present study was conducted to determine the prevalence of canine dirofilariosis in Hatay province, south of Turkey. A total of 269 blood samples were collected from owned dogs in this multi-centre survey between March and July 2006. Blood samples were examined by modified Knott and enzyme-linked immunosorbent assay (ELISA) techniques to detect circulating microfilariae and antigens of Dirofilaria immitis, respectively. Seventy out of 269 dogs (26.0%) were positive for D. immitis. However, 61.4% of positive dogs had occult infection. The prevalence of canine dirofilariosis was heterogeneous in Hatay province, with higher values in shoreline (33.0%) and riverside (30.9%) areas followed by the lowland (25.5%) or mountainous (15.2%) areas. No statistically significant differences were observed in relation to sex (females, 33.3%; males, 24.4%, P > 0.05). When evaluating the prevalence of D. immitis by age, the highest prevalence was observed in dogs older than 4 years of age. Large breeds (29.6%) and the dogs living outdoors (30.2%) showed a higher prevalence in comparison to small breeds (21.4%) and the dogs living indoors (10.5%), respectively. In conclusion, according to the results of this study canine dirofilariosis had a high prevalence in Hatay province. Therefore, prophylaxis against heartworm is advisable to decrease the incidence of canine dirofilariosis.
