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Öğe Chemical Composition of Stachys pumila Essential Oil(Springer, 2015) Kaya, Durmus Alpaslan; Guzel, Yelda; Arslan, Mehmet[Abstract Not Available]Öğe Chemotaxonomy and flavonoid profiling of Torilis species by HPLC/ESI/MS2(Pergamon-Elsevier Science Ltd, 2011) Guzel, Yelda; Aktoklu, Ekrem; Roumy, Vincent; Alkhatib, Racha; Hennebelle, Thierry; Bailleul, Francois; Sahpaz, SevserThe flavonoid profiles of Turkish Torilis Gaertn. (Apiaceae) species were studied by TLC. HPLC-UV and HPLC/ESI/MS2 (negative mode). O-glycosides of luteolin, apigenin and chrysoeriol were identified from crude extracts with the help of mass spectra in different MS/MS modes, such as full scan, precursor ion scan and product ion scan. Luteolin-7-O-glucoside and luteolin-7-O-rutinoside were common to all species. Flavonoid profiles usually differ from one species to another and can be put to use for a genus such as Torilis which has been little studied. By the help of different flavonoid profiles, it is concluded that, the plants, which are recognised as less rayed subspecies of Torilis arvensis (Huds.) Link. in various floras including Turkish one, must be classified in species category as Torilis chrysocarpa and Torilis purpurea. Flavonoid profiles seem to be in relation with evolutionary biogeography of the species. Because the most isolated species of the genus, endemic Torilis triradiata, has the most different flavonoid pattern. Moreover, geographically isolated species, T triradiata and Torilis leptocarpa, do not share any flavonoid except for the two which are common to all species. (C) 2011 Elsevier Ltd. All rights reserved.Öğe Contributions to the taxonomy of the Irano-Turanian genus Rhabdosciadium (Apiaceae): Nomenclatural notes, carpology, molecular phylogeny and the description of a new species from Bitlis (Turkey)(Magnolia Press, 2019) Firat, Mehmet; Guzel, YeldaA new Rhabdosciadium (Apiaceae) species, R. hizanense is described and illustrated from eastern Anatolia (Bitlis/Hizan). The new species has a distinct appearance with caespitose, low-growing habit and regularly pinnate, ovate-lobed leaves. It is most closely related to another recently described distinct Rhabdosciadium species, R. anatolyi, but differs from it by various features. Because R. anatolyi has been described based on a sample at the vegetative development stage, the holotype of the species has no flowers or fruits and the description of the species is incomplete. Hence, we designated a fully developed epitype for R. anatolyi. Comprehensive descriptions of both species are provided, including detailed photographs, geographical distribution maps, habitats and ecology, vernacular names, ethnobotanical usages, and IUCN conservation statuses. The phylogenetic position of the species within Rhabdosciadium, as well as within tribe Careae, was also studied based on nuclear-encoded ribosomal internal transcribed spacer region (ITS) sequence analysis.Öğe Current nomenclature and systematics of Capsella Medik. with lectotypifiications:towards solving the puzzle(Tubitak Scientific & Technological Research Council Turkey, 2022) Guzel, YeldaThe taxonomic history of Capsella Medik., one of the genera with the highest phenotypic plasticity, and thus the highest synonym number relative to the recognized species number, was reviewed. The current systematics of the genus was discussed and the exact number of taxa was determined. In light of the molecular and nomenclatural data, it was decided that the genus was represented around the world by five species and one hybrid. Considering the molecular studies that have been conducted over the 30 years it was concluded that the species of this genus are typical examples of the concept of cryptic species. The classification and nomenclature of such genetically different, morphologically similar species should be one of the most current discussion topics of modern systematic science. Capsella is one of the best examples to examine this situation; hence, this feature was discussed herein. It was decided that C. thracica and C. ?? abortiva are conspecific and the correct naming should be C. abortiva (pro hybr.). Lectotype assignments were performed for the names of 5 taxa, mainly C. rubella, C. ?? abortiva, and C. thracica. Also, the missing type specimen of the Turkish endemic C. lycia was found, the lectotype was assigned and it was determined to be a synonym of C. bursa-pastoris. Various errors in the type sample references, especially in the holotype of C. grandiflora, were thus corrected. Their distribution around the world was checked and then corrected, and an identification key is given for the taxa of the genus.Öğe Ethnobotany of medicinal plants used in Antakya: A multicultural district in Hatay Province of Turkey(Elsevier Ireland Ltd, 2015) Guzel, Yelda; Guzelsemme, Mehmet; Miski, MahmutEthnopharmacological relevance: We have compiled information about the medicinal plants used in folk medicine in the district of Antakya. Since its establishment by King Seleucus I in 300 B.C., Antakya (old Antioch) has hosted nearly 20 civilizations. Antakya, neighboring Northwestern Syria, is located on the western end of the Silk Road and was one of the great centers of Graeco-Roman world. Today, Antakya is a cosmopolitan city in which Arabic and Turkish are widely spoken, and where distinct ethnic and religious communities, such as Arab Alawite, Arab Christian, Arab Sunni, Turk Sunni, Armenian, and Jewish, have been living together in harmony for centuries. In addition, the rich flora in the vicinity of Antakya also renders the area interesting in terms of ethnobotanical fieldwork. Aim of the study: This study aimed to compile the information about plants used for medicinal purposes by local people in the district of Antakya. This city is a significant region in terms of ethnobotanical fieldwork, owing to its cosmopolitan structure, long history, relatively preserved traditional community structure, and rich flora. Furthermore, we sought to compare the ethnomedicinal data geographically, cross-culturally, and historically. Materials and methods: The ethnobotany of medicinal plants used in the district of Antakya has been investigated through two separate studies; one was conducted in 1975, interviewing 29 people, and the other was conducted in 2011-2013, interviewing 182 people. The use value (UV) and informant consensus factor (FIC) values of the plants were calculated. In order to interpret the authenticity and sources of the compiled ethnomedicinal information, previous publications that contain information about the similar medicinal uses of plants identified in our region were reviewed and evaluated meticulously. A comparison with the data obtained from other regions of Turkey and from other Mediterranean regions, as well as a cross-cultural analysis between the ethnic groups within the study area, was performed by implementation of the Jaccard index (JI) Results: Throughout the study, information about 202 medicinal plant taxa was compiled. Among these plants, 39 have either not yet been mentioned in ethnobotanical or medicinal studies, or have been used for a medicinal purpose other than those encountered in the literature review. The ethnomedicinal information we gathered from the study area exhibits close similarities to the ethnomedicinal information of other Southern and Eastern Mediterranean countries where Arabic is spoken, as well as to that of Northern and Western Mediterranean countries where Latin languages are spoken. In addition to these similarities, in most cases, this ethnomedicinal information shows hybrid features of ethnomedicinal knowledge from Eastern and Western Mediterranean countries. Conclusion: Based on a literature survey, we found that the cited medicinal uses for 43 plants have also been corroborated by other various biological testings. This finding strongly suggests the importance of ethnobotanical studies in the development of new medicines. We believe that this study has compiled rich ethnomedicinal information that reflects the cosmopolitan structure of Antakya in a very good way. (c) 2015 Elsevier Ireland Ltd. All rights reserved.Öğe Ethnoveterinary Uses of Medicinal Plants in Mediterranean District, Turkey(Chiminform Data S A, 2017) Yipel, Mustafa; Yipel, Fulya Altinok; Tekeli, Ibrahim Ozan; Guzel, YeldaEthnoveterinary Medicine (EVM) research is defined as the reevaluation of the animal disease prevention and treatment folklore dating back to 14,000 years using modern and scientific methods. The knowledge acquired in centuries by trial and error has been used in medicine and has reached today by being transferred from generation to generation. As the science of chemistry has developed after the 18th century, synthetic or semi-synthetic materials have replaced the plants as raw materials for drugs. However, the emerging problems caused by the side effects of modern drugs in the recent years have popularized the use of natural drugs again. This study is conducted in the Mediterranean Region which is ranked at the top of medical aromatic plant diversity list in Turkey. 60 participants living in the region, chosen by random sampling have been interviewed face-to-face and we have tried to measure their knowledge about the plants they use for EVM. The obtained information has enabled us to make 168 citations to 67 different plants used in animal diseases. L. nobilis L., (%7.14), Mentha spp. and Urtica urens L. (%4. 17) were the most prominent among these plants and it was reported that the medicinal plants were mostly used for gastrointestinal disorders (%26). Although EVM parctices reached today and are still being widely applied, the recorded information about this subject in Turkey and many other countries is inadequate. This study presents information about the plants used in Turkey's Mediterranean region for EVM and how they are used to treat which diseases.Öğe Evaluation of the antioxidant and cytotoxic potency of Euphorbia rigida and Arbutus andrachne methanol extracts in human hepatocellular carcinoma cell lines in vitro(Springernature, 2021) Aslanturk, Ozlem Sultan; Yilmaz, Ebru Sebnem; Celik, Tulay Askin; Guzel, YeldaBackground Ethnobotanical studies on plants and their active compounds take a great interest in traditional medicine. After pharmacological and toxicological studies, there will be a possibility to be used in therapy. This study aimed to examine the in vitro antioxidant and cytotoxic activity of the methanol extracts of Arbutus andrachne L. and Euphorbia rigida M.Bieb. 10, 25, 50, 75, 100 and 150 mu g mL(-1) concentrations of A. andrachne and E. rigida were tested for antioxidant activity by using DPPH radical scavenging assays, total antioxidant capacity (phosphomolybdate assay) and and metal ion chelating activity. In addition, in vitro cytotoxic effects of this plants methanol extracts on Hep3B and HepG2 human hepatocellular carcinoma cell lines were evaluated at 24, 48 and 72 h. The cytotoxicity test was carried using the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] assay. Results Methanol extract obtained from both plants showed increased antioxidant activity depending on the increase in concentration. When A. andrachne and E. rigida methanol extracts were compared in free DPPH scavenging activity, total antioxidant capacity and metal ion chelating activity, A. andrachne methanol extract was found more effective than E. rigida. Results from MTT assay revealed that except for 72 h treatment of HepG2 cells with 400 and 500 mu gmL(-1) extract concentrations, A. andrachne methanol extract did not show significant cytotoxic effects on either Hep3B or HepG2 cells at any concentration and treatment time. On the contrary, it significantly increased proliferation in Hep3B cells from 48 h and at a concentration of 100 mu g mL(-1). E. rigida methanol extract exhibited statistically significant cytotoxic activity on HepG2 cells after 48 and 72 h treatment. However, the treatment concentrations of E. rigida methanol extract were not as effective on Hep3B cells as on HepG2 cells. Conclusions According to our findings, it was determined that A. andrachne methanol extract did not have cytotoxic activity on neither Hep3B nor HepG2 cells, while E. rigida methanol extract had cytotoxic activity especially on HepG2 hepatocellular carcinoma cells. Further research is needed to identify and purify the active ingredients in E. rigida extracts.Öğe Hemostatic effects of traditional Inula viscosa and Capsella bursa-pastoris plant mixture extract on rat liver parenchymal bleeding model(Turkish Assoc Trauma Emergency Surgery, 2022) Ozturk, Ozan Utku; Ugur, Mustafa; Guzel, Yelda; Ozturk, Mehmet Ali; Gursoy, Didar; Dogan, Serdar; Temiz, MuhyittinBACKGROUND: Failure to achieve effective bleeding control and problems related to transfusion in liver surgery are the most common causes of post-operative mortality and morbidity. Various methods/drugs including topical hemostatic agents have been employed for bleeding control in liver surgery. This study was aimed to investigate the hemostatic properties of the herb mixture extract of Inula viscosa and Capsella bursa-pastoris (IvCbp) in rat liver laceration model, which have been traditionally used as antiseptic and hemostatic agents public in Hatay/Tukey. METHODS: Thirty rats were divided into three groups equally and blood samples were taken from all rats for preoperative hemoglobin (Hb) measurements. Then, the standard liver resection model was applied to all rats. Sponge for the first rat group, Ankaferd Blood Stopper (R) Trend-Tech for the second rat group and IvCbp plant extract mixture for the third group were applied to resection areas for 3 minutes. Liver samples of all rats were evaluated in terms of inflammation and necrosis intensity on the 5th post-operative day. RESULTS: operative Hb values were found as 11.0 +/- 1.1 g/dL in the sponge group, 11.9 +/- 2.0 g/dL in the Ankaferd group, and 14.I +/- 1.2 g/dL in the IvCbp herb mixture group (p<0.001). In the histopathological examination, less necrosis was observed in the herb mixture group compared to the sponge and Ankaferd groups (p=0.001). In addition, no statistically significant necrosis difference was observed between sponge and Ankaferd groups. While less inflammation was observed in the herb mixture group compared to the other groups, Ankaferd group had the highest inflammation score (p<0.001). CONCLUSION: IvCbp herb mixture extract group provide effective hemostatic control, caused less Hb decrease and resulted in less inflammation and necrosis compared to Ankaferd and sponge groups in a rat liver resection model.Öğe Humulane and Germacrane Sesquiterpenes from Ferula lycia(Amer Chemical Soc, 2010) Alkhatib, Racha; Hennebelle, Thierry; Joha, Sami; Roumy, Vincent; Guzel, Yelda; Biabiany, Murielle; Idziorek, ThierryFive new juniferol esters (1-5), along with six known humulane derivatives (6-11), were isolated from the roots of Ferula lycia, an endemic Turkish species. The fruits of the same species were also investigated and led to the isolation of these same compounds, as well as two known germacrane esters (12 and 13). All isolated sesquiterpenes were assayed for cytotoxicity against two tyrosine kinase inhibitor-resistant cell lines, K562R and DA1-3b/M2(BCR-ABL). The two most active compounds, juniferinin (7) and 6-beta-p-hydroxybenzoyloxygermacra-1(10),4-diene (12), were moderately active against Raji lymphoma cells but also displayed some toxicity against healthy bone marrow cells.Öğe A new Dionysia (Primulaceae) species from southern Turkey, the most western species of the Irano-Turanian genus(Magnolia Press, 2021) Guzel, YeldaA new Dionysia species, D. zeynepiae, is described from Antakya, a Mediterranean province in southern Turkey. It differs from all other known species of the genus by the presence of the trifid corolla lobes (vs. entire, emarginate or bifid lobes). This is the most western and most separated population of this mostly Irano-Turanian genus, which is distributed mainly in the Zagros Mountains (Iran) and adjacent areas. The floral morphology of the heterostylous flowers is also described in detail.Öğe Noccaea ali-atahanii (Brassicaceae): a new species from southern Anatolia(Tubitak Scientific & Technological Research Council Turkey, 2018) Guzel, Yelda; Ozudogru, Baris; Kayikci, Samim; Ozgisi, KurtulusNoccaea ali-atahanii, a new Brassicaceae species from southern Anatolia, is described herein. It is mostly similar to N. aghrica, but can be readily distinguished by the presence of apical placentation and orbiculate fruit with wings extending almost evenly from the base to the apex. Its phylogenetic relationships within the genus are provided based on the nuclear-encoded ribosomal internal transcribed spacer region. Carpological and ecological features of N. ali-atahanii and related species are also discussed.Öğe PHENOLIC COMPOSITION, ANTIOXIDANT CAPACITY OF SALVIA VERTICCILATA AND EFFECT ON MULTIDRUG RESISTANT BACTERIA BY FLOW-CYTOMETRY(African Networks Ethnomedicines, 2014) Tekeli, Yener; Karpuz, Esra; Danahaliloglu, Hatice; Bucak, Serbay; Guzel, Yelda; Erdmann, HelmuthBackground: Antioxidants are of great importance for preventing oxidative stress that may cause several degenerative diseases. Studies have indicated phytochemicals have high free-radical scavenging activity, which helps to reduce the risk of chronic diseases. The aim of the present study is the determination of antioxidant properties, polyphenolic content and multidrug resistant bacteria of Salvia verticcilata L. Materials and Methods: Methanol was used as the extraction solvent. The total phenolic content was calculated using Folin-Ciocalteau method and phenolic composition was determined by HPLC. The radical scavenging activity of plant was evaluated in vitro based on the reduction of the stable DPPH free radical. The reducing capacity was identified by using the FRAP method. The ability of Salvia verticcilata L. to increase the permeability of multidrug resistant bacterial cells was conducted by flow cytometric assay on Listeria innocua and E-coli. Results: The amount of total phenolics was found to be 347.5 mg GA/g extract. The IC50 value and FRAP assay are 0.61, and 0.944 respectively, Free radical scavenging effect and FRAP values are less than synthetic antioxidant compounds (BHA and BHT). Eight phenolic compounds were found in Salvia verticcilata L. Intense concentration of S. verticcilata L. has destroyed 97 % of living cells for Listeria innocua and 94.86% for E-coli Conclusion: This studyshows that methanolic extracts of Salvia verticcilata L. is a potential source of natural antioxidants and antimicrobial agent and can form the basis for pharmacological studies.Öğe Rediscovery and reinstatement of Heracleum amanum (Apiaceae) based on morphological and carpological data(Magnolia Press, 2017) Guzel, Yelda; Kayikci, SamimHeracleum amanum was only known so far from the material collected in the Amanos Mountains, near Belen (southern Turkey) in 1862 by C.G.T. Kotschy, which was referred to in the protologue. This taxon was considered a mere variant of H. crenatifolium in Flora of Turkey, and apparently it had never been collected again. In the present contribution, the rediscovery of H. amanum is reported about 150 years after the first publication of the name, and recent gatherings are compared to samples of H. crenatifolium on the basis of carpological and morphological data. As a result of the investigations carried out, H. amanum and H. crenatifolium are suggested here to be treated as separate species, both endemic to Turkey. Distribution and habitat data, as well as their conservation status, are assessed for each one.Öğe Scorzonera pacis (Asteraceae), a new species from Hatay, Turkey(Finnish Zoological Botanical Publishing Board, 2013) Guzel, Yelda; Kayikci, Samim; Yildiz, SerhatA new species, Scorzonera pacis Ouzel, Kayikci & S. Yildiz (Asteraceae) from Hatay Province, South Anatolia is described. It is a very distinct species with its saw-toothed, winged achenes. SEM micrographs of the achenes, notes on the habitat and distribution, and a comparison with its morphologically closest species are provided.Öğe Specialized natural product analysis and chemophenetics of some Turkish endemic Centaurea L. (Asteraceae) taxa by electrospray ionization mass spectrometry fingerprinting and liquid chromatography-tandem mass spectrometry(Pergamon-Elsevier Science Ltd, 2020) Guzel, YeldaSpecialized natural product analysis of six Turkish endemic and two narrowly distributed Centaurea L. taxa was performed via electrospray ionization mass spectrometry (ESI-MS) fingerprinting and liquid chromatography-tandem mass spectrometry (LC-MS/MS), which is an effective methodology that is widely used for fast screening of complex natural mixtures such as food extracts, but not has not been used as commonly for plant chemophenetics. This method is preferable when it is aimed to compare a large number of plant extracts for chemophenetic purposes and when it is difficult to provide equally good chromatographic separation in all of the extracts. ESI-MS shows the major compounds in fingerprinting extracts. LC-MS/MS provides identification according to fragmentation with the advantage of MS/MS, and validation can be performed in selected reaction monitoring (SRM) mode with simultaneous precursor and product ion scans. Herein, sixteen flavones, four flavonols, four flavanones, two lignans, three sesquiterpene lactones, and four phenolic acids, a total of thirty three substances, were identified tentatively or unambiguously from the extracts. It was concluded that ESI-MS fingerprinting is a suitable method for plant chemophenetics when coupled and validated with LC-MS/MS. Moreover, it was concluded that sesquiterpene lactones, lignans, and flavonoids are suitable for taxonomic purposes in Centaurea owing to species-specific metabolite profiles.
