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Öğe Adrenal miyelolipom : Olgu sunumu(2008) Hakverdi, Sibel; Görür, Sadık; Temiz, Muhyittin; Akarsu, Bülent; Kiper, Ahmet NamıkAdrenal miyelolipomlar ender görülen benin tümörlerdir. Sıklıkla boyutları 5 cm’nin altındadır ve belirti vermezler. Burada adrenal miyelolipomlu bir olguyu sunuyor ve yayın bilgileri ışığında değerlendiriyoruz. Sağ kasığa vuran yan ağrısı olan 60 yaşındaki kadın hastada ultrasonografi ve bilgisayarlı tomografi ile sağ adrenal bez yerleşiminde yaklaşık 8 cm boyutta kitle tanımlandı. Ameliyat edilen hastanın materyalinin histopatolojik değerlendirmesinde matür yağ doku ve kemik iliği elemanlarından oluşan tümöre adrenal miyelolipom tanısı kondu. Adrenal bölgede bulunan ve yağ içeriği yüksek olan olgularda ayırıcı tanıda adrenal miyelolipom düşünülmelidir. Kitlenin olguda belirti verip vermemesi ve büyüklüğüne göre tedavi şekli planlanmalıdır.Öğe Adrenal myelolipoma: Case report(2008) Hakverdi, Sibel; Görür, Sadik; Temiz, Muhyittin; Akarsu, Bülent; Kiper, Ahmet NamikIntroduction: Adrenal myelolipoma are rare occurring benign tumors. They are generally less than 5cm and may not cause symptoms. We discuss a case with adrenal myelolipoma in the light of literature. A 60 year-old female patient had strait flank pain radiate to inguinal region. In the right adrenal gland, a mass about 8 cm was specified by ultrasonography and computerized tomography imaging. In the hystopathological evaluation of the completely resected mass, it was determined that the mass was composed of mature adipose tissue and hematopoetic elements, and the tumor was described as adrenal myelolipoma. In the cases with masses localized in the adrenal gland, adrenal myelolipoma should be considered. Therapy procedure should be planned according to size of the tumor and the presence of symptoms.Öğe ADRENAL MYELOLIPOMA: CASE REPORT(Aves, 2008) Hakverdi, Sibel; Gorur, Sadik; Temiz, Muhyittin; Akarsu, Bulent; Kiper, Ahmet NamikAdrenal myelolipomas are rare occurring benign tumors. They are generally less than 5cm and may not cause symptoms. We discuss a case with adrenal myelolipoma in the light of literature. A 60 year-old female patient had strait flank pain radiate to inguinal region. In the right adrenal gland, a mass about 8 cm was specified by ultrasonography and computerized tomography imaging. In the hystopathological evaluation of the completely resected mass, it was determined that the mass was composed of mature adipose tissue and hematopoetic elements, and the tumor was described as adrenal myelolipoma. In the cases with masses localized in the adrenal gland, adrenal myelolipoma should be considered. Therapy procedure should be planned according to size of the tumor and the presence of symptoms.Öğe Anormal uterin kanamalı kadınlarda uterus içi lezyonların tespitinde dilatasyon ve küretajın tanısal değeri(2008) Hakverdi, Sibel; Güngören, Arif; Hakverdi, Ali Ulvi; Dolapçıoğlu, Kenan; Çiftçi, Şinasi; Kaya, Zozan; Yalınkaya, AhmetAMAÇ: Histerektomi sonrası elde edilen histolojik bulgularla, Dilatasyon ve küretajdan ( D&C) elde edilen histolojik bulguları karşılaştırarak, D&C’nin teşhis açısından yetersizliğini değerlendirmek. Bu retrospektif çalışmada, D&C’nin teşhis açısından kesinliğini tespit etmeyi araştırdık. MATERYAL-METOD: Anormal uterin kanamalı 259 hasta değerlendirildi. Kadınların hepsine jinekolojik ve ultrasonografik muayene uygulandıktan sonra anestezi altında D&C işlemi uygulandı.Semptomların devam etmesinden ya da histolojik bulgulardan dolayı histerektomi gerçekleştirildi. Her hastanın histerektomi ve D&C sonrası histolojik bulgularını karşılaştırmaya çalıştık. SONUÇLAR: Semptomların devam etmesinden ya da histolojik bulgulardan dolayı D&C’den sonraki 2 ay içinde histerektomi gerçekleştirilen 259 hastayı değerlendirdik. Kadınların % 54.5’inde D&C’de patoloji saptanmadı. Diğer hastaların % 59,5’inde patolojik düzensizlikler histerektomide de mevcuttu. 259 hastanın 105’inde histerektomide sıklıkla bulunan intrauterin patolojileri tespit etmede, D&C yetersiz kaldı. Histerektomiden sonra, 259 hastanın 227’sinde D&C deki histolojik teşhise ilave patolojik düzensizlikler bulundu. TARTIŞMA: D&C, serviks laserasyonu ve enfeksiyonu ile uterus perforasyonunu içeren komplikasyonların riskine ve ilave hastane maliyetine yol açar. Uterusta lezyonlar mevcutsa D&C teşhis aracı olarak yetersiz kalır. D&C, alınan uterusta mevcut olan endometrial lezyonların ve majör intrauterin düzensizliklerin % 40.5’ini tanımaz. D&C iyileştirici bir araç olmayabilir. İntrauterin patolojilerin teşhisi için, alternatif ve daha doğru metodların D&C ın yerine kullanılması önerilmektedir.Öğe Axillary lipogranuloma mimicking carcinoma metastasis after silicone breast implant rupture: A case report(Elsevier Sci Ltd, 2013) Gundeslioglu, A. Ozlem; Hakverdi, Sibel; Erdem, Ozlem; Ozen, E. Cigdem; Inan, Irfan; Emlik, DilekSilicone-gel-filled breast implants have been widely used for breast augmentation and reconstruction after mastectomy. However, silicone implants have some well-known complications, such as implant rupture, which requires surgical intervention. Dissemination of silicone particles out of the implant causes a granulomatous reaction, a phenomenon known as silicone granuloma, in breast parenchyma as well as axillary, breast and chest wall lymph nodes, which mimics breast cancer metastasis. However, lipogranuloma after silicone breast implant rupture has not been reported in the literature, although it is a common complication after mineral oil or liquid silicone injection. We present a case report of an axillary lymphadenopathy resulting from lipogranuloma after silicone-gel-filled implant rupture. Review of the literature suggests that this is the first report of a lipogranuloma resulting from implant rupture. (C) 2012 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.Öğe Blaschko çizgileri dağılımlı iki lineer liken planus olgusu(2008) Serarslan, Gamze; Hakverdi, SibelLiken planus, deri ve mukozaları tutabilen, inflamatuar bir deri hastalığıdır. Lineer liken planus, liken planusun nadir görülen bir formudur ve tüm liken planuslu hastaların yaklaşık %0.2’sini oluşturur. Alt ekstremitede lineer liken planus lezyonu olan ve Blaschko çizgileri boyunca dağılım gösteren iki olgu sunmaktayız.Öğe Caffeic acid phenethyl ester suppresses oxidative stress in Escherichia coli-induced pyelonephritis in rats(Springer, 2007) Celik, Sefa; Gorur, Sadik; Aslantas, Ozkan; Erdogan, Suat; Ocak, Sabahattin; Hakverdi, SibelAlthough oxidative damage is known to be involved in inflammatory-mediated tissue destruction, modulation of oxygen free radical production represents a new approach to the treatment of inflammatory diseases. Caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives, has antioxidant, anti-inflammatory and antibacterial properties. For that reason, we aimed to investigate the efficiency of CAPE administration in preventing oxidative damage in pyelonephritis (PYN) caused by Escherichia coli. In this study, 35 Wistar rats were grouped as follows: control, PYN 24 h, PYN 48 h, PYN 72 h, CAPE 24 h, CAPE 48 h and CAPE 72 h. E. coli (1 x 10(9) c.f.u.) were inoculated into the rats in both PYN and CAPE groups via urethral catheterization. Ten mu M/kg-body weight CAPE was injected to the rats in all CAPE groups 24 h before E. coli infection, and injections were repeated at 24-h intervals. Rats were sacrificed 24 h, 48 h and 72 h after infection in both PYN and CAPE groups. Malondialdehyde (MDA) and nitric oxide (NO) levels were significantly increased in kidneys of PYN groups. The activities of the antioxidant enzymes, catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and xanthine oxidase (XO) were also elevated by E. coli. However, CAPE administration reduced MDA and NO levels, as well as XO activity, although it increased SOD and GSH-Px activities. Histopathological examination showed that CAPE reduced the inflammation grade induced by E. coli. In conclusion, CAPE administrations decrease the oxidative damage occurring in PYN and therefore could be used for medical management of bacterial nephropathy.Öğe Chromosome Imbalances and Alterations in the p53 Gene in Uterine Myomas from the Same Family Members: Familial Leiomyomatosis in Turkey(Asian Pacific Organization Cancer Prevention, 2013) Hakverdi, Sibel; Demirhan, Osman; Tunc, Erdal; Inandiklioglu, Nihal; Uslu, Inayet Nur; Gungoren, Arif; Erdem, DuyguUterine leiomyomas (UL) are extremely common neoplasms in women of reproductive age, and are associated with a variety of characteristic choromosomal aberrations (CAs). The p53 gene has been reported to play a crucial role in suppressing the growth of a variety of cancer cells. Therefore, the present study investigated the effects of CAs and the p53 gene on ULs. We performed cytogenetic analysis by G-banding in 10 cases undergoing myomectomy or hysterectomy. Fluorescence in situ hybridization (FISH) with a p53 gene probe was also used on interphase nuclei to screen for deletions. In patients, CAs were found in 23.4% of 500 cells analysed, significantly more frequent than in the control group (p<0.001). In the patients, 76% of the abnormalities were structural aberrations (deletions, translocations and breaks), and only 24% were numerical. Deletions were the most common structural aberration observed in CAs. Among these CAs, specific changes in five loci 1q11, 1q42, 2p23, 5q31 and Xp22 have been found in our patients and these changes were not reported previously in UL. The chromosome breaks were more frequent in cases, from high to low, 1, 2, 6, 9, 3, 5, 10 and 12. Chromosome 22, X, 3, 17 and 18 aneuploidy was observed to be the most frequent among all numerical aberrations. We observed a low frequency of p53 losses (2-11%) in our cases. The increased incidence of autosomal deletions, translocations, chromatid breaks and aneuploidy, could contribute to the progression of the disease along with other chromosomal alterations.Öğe Comparison of Head and Neck Cancer Distribution in Turkish and Syrian Populations(Iranian Scientific Society Medical Entomology, 2019) Serindere, Gozde; Bolgul, Behiye; Gursoy, Didar; Hakverdi, Sibel; Savas, NazanBackground: Although oral health improves in several countries, global problems are still present. Predictably, the disadvantaged and poor population groups in both developing and developed countries have high rate of malign disease. The aim of this study was to evaluate the prevalence of head and neck cancers (HNCs) and to compare them between Syrian and Turkish population. Methods: A total of 4570 patients confirmed to have HNC histopathologically from Hatay Mustafa Kemal University Hospital Pathology report archive were retrospectively evaluated. Among them, 452 were Syrian patients while 4118 were Turkish patients. Data were collected from 2010 to 2017. Gender and age information were taken from medical records. According to the pathological results, HNCs were classified. Results: In 474 patients, HNCs were inscriprived, of which 317 were in males and 157 in females aged 23-80 years with histologically approved cancer of head and neck area. Overall, 100 were Syrian patients while 374 were Turkish patients. In both Syrian and Turkish patients, the most observed HNC was squamous cell carcinoma (SCC). Conclusion: Nowadays, the prevalence of cancer is higher because of the excessive consumption of alcohol, tobacco, chewing, and smoking. For the higher cancer incidence in Syrian refugees, we thought that the impact of war such as stress may have been effective as well as the known several etiologic factors of cancer. For the increased risk of cancer, the early diagnosis of this become more important.Öğe Çukurova yöresinde seyrek yerleşimli ekinokokkozis (134 olgu )(2009) Hakverdi, Sibel; Sayar, Hamide; Yaldız, Mehmet; Erdoğan, Şeyda; Akansu, Bülent; Canda, Şerefettin M.Ekinokokkozis tarım ve hayvancılığın yaygın olduğu toplumlarda sıklıkla görülen paraziter bir hastalıktır. Türkiye'de Doğu Anadolu, İç Anadolu, Marmara ve Trakya bölgelerinde daha sık izlenmektedir. Yüksek oranda karaciğer ve akciğerde yerleşim gösteren ekinokkokozis seyrek olarak diğer doku ve organlarda da görülebilir. Bu çalışmada Çukurova bölgesinde, 10 yıllık sürede, 962 ekinokokkozis olgusu saptadık. Bu olguların 134'ü (%13,9) akciğer ve karaciğer dışı yerleşimdedir. Seyrek yerleşim gösteren ekinokokkozis olgu oranlarını belirlemek ve konu üzerine dikkati çekmeyi amaçladık.Öğe Delayed Diagnosis: Giant Basal Cell Carcinoma of Scalp(Deri Zuhrevi Hastaliklar Dernegi, 2008) Balci, Didem Didar; Serarslan, Gamze; Hakverdi, SibelAlthough basal cell carcinoma (BCC) is the most common form of skin cancer, the scalp lesions of BCC have been rarely reported. Giant BCC is defined as a tumor larger than 5 cm in diameter and only 0.5-1% of all BCCs achieve this size. We report a case of giant BCC on the scalp that was treated with topical coticosteroids and antifungal shampoo for five years. BCC should be considered in the differential diagnosis in erythematous plaque type lesions resistant to therapy with long duration localized on the scalp. (Turkderm 2008; 42: 67-9)Öğe DIAGNOSTIC VALUE OF DILATATION AND CURETTAGE TO DETECT INTRAUTERINE LESIONS IN WOMEN WITH ABNORMAL UTERINE BLEEDING(Galenos Yayincilik, 2008) Hakverdi, Sibel; Gungoren, Arif; Hakverdi, Ali Ulvi; Dolapcioglu, Kenan; Ciftci, Sinasi; Kaya, Zozan; Yalinkaya, AhmetObjective: To evaluate the diagnostic inadequacy of dilatation and curettage (D&C) by comparing histologic findings derived from D&C with histologic findings obtained after hysterectomy procedure retrospectively. Material and methods: Files of 259 patients with abnormal uterine bleeding who underwent hysterectomy within two months of a diagnostic D&C were analyzed. All patients had gynecologic and ultrasonographic examination, then they underwent D&C procedure under anesthesia. Hysterectomy was performed accordingly due to the histologic findings or persistence of the symptoms. Histologic diagnosis in D&C and after hysterectomy for each patient were compared. Results: 54.5% of the women had no pathology in D&C techniques. 59.5% of remaining patients had the same the pathologic findings in the hysterectomy specimens. In 105 of 259 patients, D&C failed to detect intrauterine disorders subsequently found at hysterectomy. After hysterectomy, in 227 of 259 patients were found additional pathologic abnormalities besides the histologic diagnosis in D&C specimens. Conclusions: D&C involves additional hospital costs and risk of complications; uterine perforation, infection and laceration of the cervix. If there are lesions in the uterus, dilatation and curettage is an inadequate diagnostic tool. D&C missed 40.5% of major intrauterine disorders and endometrial lesions were still present in the removed uterus. Therefore D&C can not be assessed as a therapeutic tool. Therefore D&C is suggested to be replaced by alternative and more accurate methods of diagnosis of endometrial abnormalities.Öğe Effect of mesalamine on healing in experimental colon anastomosis: A randomised experimental study(2008) Aslan, Ahmet; Temiz, Muhyittin; Hakverdi, Sibel; Polat, Gurbuz; Tumer, Cemil; Temiz, Abdulkerim; Canbolant, ElifObjective: We aimed to investigate the effect of mesalamine on healing of experimental colon anastomosis model. Material/Methods: Forty adult male Wistar albino rats were performed segmentary colonic resection and end-to-end anastomosis. Animals were randomly divided into four groups: group I, anastomosis group, received no treatment (GI, n = 8); group II, anastomosis + oral mesalamine group (100 mg/kg/day); group III, anastomosis + rectal mesalamine (2 mL) group, (GIII, n = 8); group IV, anastomosis + oral mesalamine + rectal mesalamine (GIV, n = 8) group. A sham group (n = 8) was constituted and was performed laparotomy. Bursting pressure, hydroxyproline levels and histopathological characteristics of the anastomosis were analyzed. Results: Although it was not statistically significant, there was an increase in the burst pressure of the mesalamine group. When hydroxyproline measurements were compared there were statistically significant difference between the non-treated colon and all groups. There were significant differences between GI and GIII-GIV, GII and GIV. The differences between group I and II and group II and III were not statistically significant. When we compared the median amount of the histopathological changes, we found significant difference between the anastomosis and the mesalamine groups (P < 0.05). But when mesalamine groups were compared with each other we did not observe a significant difference. Conclusion: Mesalamine had positive effects which were not statistically significant on bursting pressure and statistically different significant effects on hydroxyproline (HP) levels based on the way of administration and statistically significant positive effects on histopathologic anastomotic healing in experimental anastomosis model. © 2007 Surgical Associates Ltd.Öğe Effect of propolis on healing in experimental colon anastomosis in rats(Springer, 2008) Temiz, Muhyittin; Aslan, Ahmet; Canbolant, Elif; Hakverdi, Sibel; Polat, Gurbuz; Uzun, Semire; Temiz, AbdulkerimIntroduction: Propolis is the generic name for the resinous substance collected by honeybees, which is known to have antioxidant, anti-inflammatory, apoptosis-inducible effects. Anastomotic dehiscence after colorectal surgery is an important cause of morbidity and mortality. We aimed to assess the effect of propolis on healing in an experimental colon anastomosis in rats. Methods: Forty adult male Wistar albino rats were randomly assigned into 5 treatment groups with 8 rats in each: Group I, anastomosis+no treatment; Group II, anastomosis+oral propolis ( 600 mg/ kg/ d); Group III, anastomosis+oral ethyl alcohol ( 1 cc/ d); Group IV, anastomosis+rectal propolis ( 600 mg/ kg/ d); Group V, anastomosis+rectal ethyl alcohol ( 1 cc/ d). The bursting pressures, hydroxiproline levels and histopathological changes in each group were measured. Results: When bursting pressures were compared between groups, we observed that they were increased in the groups treated with propolis in contrast to all other groups. Hydroxiproline levels in the propolis groups were also significantly increased in contrast to the other groups. There was also a statistically significant difference in histopathological changes between the treatment types. When propolis administration methods were compared, we did not observe a statistically significant difference. Conclusion: Propolis has a significantly favourable effect on healing in experimental colon anastomosis, independent from the method of administration.Öğe Effect of the N-acetylcysteine and selenium on healing of experimental maxillary sinusitis caused by Staphylococcus aureus(Academic Journals, 2012) Akoglu, Ertap; Hakverdi, Sibel; Kontas, Tunay; Duran, Nizami; Altug, Muhammed Enes; Onel, Suleyman Ercument; Okuyucu, SemsettinThe purpose of this controlled-randomised study was aimed to test the antioxidative effect of the N-acetylcysteine (NAC) and selenium on healing of Staphylococcus aureus sinusitis. After experimental sinusitis, 30 New Zealand rabbits were randomly divided into three groups; group A was treated with Ampicillin/sulbactam and physiological saline. Group B and C were treated with NAC and selenium in addition to Ampicillin/sulbactam, respectively. The measurements were repeated at the 3rd and 10th day. Serum malondialdehyde (MDA) levels and superoxide dismutases (SOD) activities at the 3rd day of experiment were higher than basal levels in all groups. These levels at the 10th day were lower than those of the 3rd day in groups B and C, significantly. The severity of the grade of inflammation and epithelial changes were significant between the infected and control side, but no significant change was found among the groups. S. aureus sinusitis causes to increase the level of reactive oxygen species (ROS) in the blood. These increased levels of ROS can be neutralized in some degree by antioxidative effects of NAC and selenium which are supplemented to standard antibiotic therapy. The effect of NAC and selenium on healing of maxillary sinus mucosa seems to be insignificant.Öğe Effects of caffeic acid phenethyl ester on renal damage in rabbits with partial ureteral obstruction(2009) Akçora, Bülent; Altu?, Muhammed Enes; Hakverdi, Sibel; Kontaş, Tünay; Öztürk, Atakan; Bayraktar, SuphiObstructive urologic diseases may cause renal injury related to intensty and duration of occlusion. In experimental studies, many pharmacological agents were used to decrease the harmful effects of obstruction on kidney. This study was designed to investigate effects of caffeic acid phenethyl ester (CAPE) on the parsial ureteral obstruction in rabbits. Twenty-one New Zealand rabbits were divided randomly into 3 groups each containing 7 animals. Group 1, 2 and 3 were defined as control (sham), partially obstructed, and partially obstructed plus CAPE treatment, respectively. All animals were sacrified at the end of 3 weeks. Malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD) and myeloperoxidase (MPO) levels were measured. In addition, kidney tissues stained with Hematoxylin-eosine were evaluated using Cleasson's histopathological criteria. MDA, NO and SOD levels were not significantly different among all groups. Mean MPO levels of groups 1, 2 and 3 were 0.22±0.07 U/g protein, 0.36±0.09 U/g protein, 0.27±0.10 U/g protein respectively. A significant increase was found in group 2 when compared to group 1(p<0.05). Kidneys of group 3 were significantly protected in terms of 2 out of 9 histopathologic criteria when compared to group 2 (p<0.05). There was significant difference between group 2 and group 3 in terms 2 out of 9 histopathologic criteria (p<0.05); injury of kidneys in group 3 was less than in group 2. MDA, NO and SOD levels which are used to detect renal injury in complete ureteral obstruction model, did not show any significant difference in partial obstruction model in our study. In the light of our biochemical and histopathologic findings, we can say that CAPE treatment has a tendency to decrease the degree of renal injury in the partial obtruction model. © 2009 OMÜ Tüm Haklari Saklidir.Öğe Effects of intrauterine device and oral contraceptive on vaginal flora and epithelium(Saudi Med J, 2007) Ocak, Sabahattin; Cetin, Meryem; Hakverdi, Sibel; Dolapcioglu, Kenan; Gungoren, Arif; Hakverdi, Ali U.Objectives: To investigate the microbial and cytopathological changes and genital symptoms in oral contraceptive pill (OCP) and intrauterine contraceptive device (IUCD) users. Methods: Included in the study were 34 women using OCP and 34 women using IUCD for 24 to 36 months period and 34 women as control group. We conducted the study between March to September 2005 in Antakya Maternity Hospital, Turkey. Vaginal discharge was subjected to wet mount examination, gram staining, and culture. Cervical smears were examined and reported using the Bethesda system as reference. Results: In the IUCD group, women with intermediate score was 20.6%, while those with bacterial vaginosis was 11.7%. In the OCP group however, women with intermediate score was 8.8%, while those with bacterial vaginosis was 5.9%. Compared to the control group, these rates were 2.9% for those with intermediate score and 2.9% for those with bacterial vaginosis. Escherichia coli vaginal colonization increased by 5-fold in the IUCD users (P<0.05). Cervical erosion was found in 14.7% of the women using IUCD as compared to the other groups (p<0.05). Actinomyces like organisms was detected in 11.7% of the IUCD users (P<0.05). Conclusion: The use of IUCD clearly alter the normal vaginal flora, although OCP appears to have minimal effects on the vaginal microbial flora. The data support the hypothesis that IUCD might change cervico vaginal environment, and suggests that women with IUCD may be at a higher risk for vulvovaginal infection.Öğe Effects of probiotic use on bacterial translocation in created rat models with biliary obstructions(Atatürk Üniversitesi, 2019) Çelikkaya, Mehmet Emin; Akçora, Bülent; Hakverdi, Sibel; Özer, Burçin; Ulutaş, Kemal Türker; Duran, NizamiObjective: The aim of this study was to investigate the protective effects of the combined use of probiotic strains on the development of bacterial translocation in addition to liver and intestinal tissue damage due to biliary obstruction in rats. Materials and Methods: Here, 3 groups each consisting of 10 rats were created:group 1 (sham group), group 2 (obstructive jaundice), and group 3 (obstructive jaundice+probiotic). Groups 1 and 2 were given 1 cc physiological saline solution by oral gavage twice a day; group 3 was given a probiotic solution that included Lactobacillus acidophilus, Lactobacillus rhamnosus, Bifidobacterium bifidum, Enterococcus faecium, and Bifidobacterium longum microorganisms by oral gavage twice a day. Results: Markers for liver damage were also found to be significantly improved (p<0.05) in the treatment group (group 3). Whencompared with groups 2 and 3 in terms of liver histology, damage was found to be significantly more severe in group 2 (p<0.01). With regard to ileal villous depth and ileal inflammation, the pathology was found to be significantly more severe in group 2 than that in group 3 (p<0.05). In blood, spleen, and mesenteric lymph node cultures, group 2 showed a microbiological growth rate of 33.8–58.8%, whereas group 3 showed a microbiological growth rate of 14.3–28.6%. This reduction was evaluated to be statistically significant (p<0.05). Conclusion: Our study showed that the combined use of a probiotic in bile duct obstructions reduced bacterial translocation and alleviated pathological changes arising in the liver and terminal ileum histologyÖğe Ekinokokkozis olgularının histopatolojik yönden retrospektif olarak değerlendirilmesi(2013) Özgür, Tümay; Kaya, Özlem Aycan; Hakverdi, Sibel; Akın, Mustafa; Hamamcı, Berna; Yaldız, MehmetAmaç: Çalışmada Ocak 2008-Haziran 2013 yılları arasında cerrahi kliniklerden patoloji laboratuvarına gönderilen ve patolojik olarak kist hidatik tanısı konulan 28 olguya ait materyallerin retrospektif olarak değerlendirilmesi amaçlandı. Yöntemler: Hastanemizde kist hidatik tanısı konulan 28 olgunun kayıtları incelendi; hastaların yaş ve cinsiyet bilgileri ile kist hidatik lokalizasyonları kaydedildi. Bulgular: Histopatolojik incelemesi yapılmış kist hidatik olgularında en sık lokalizasyonun 19 (%68) olgu ile karaciğerde, 7 (%25) olgu ile akciğerde, 1 (%3,5) olgu ile gluteal bölgede ve 1 (%3,5) olgu ile sağ aksiller bölgede bulunduğu saptandı. Hastaların 15 (%54)’i erkek 13 (%46)’ü ise kadındı. Olguların yaşları 7 ile 73 arasında olup erkeklerde yaş ortalaması 30,2±19,5 yıl, kadınlarda ise yaş ortalaması 35,9±19,2 idi. Ayrıca hidatik kist olgularının patolojik incelemesinde 2 (%7,1) olguda nekroz tesbit edildi. Sonuç: Kist hidatiğin endemik olduğu bölgelerde özellikle kistik cerrahi örneklerin tamamının patolojik değerlendirilmesinde bu parazite ait yapıların dikkatle incelenmesi önemlidir.Öğe Endometriosis within the ephisiotomy scarring: Case report(2007) Güngören, Arif; Hakverdi, SibelEndometriosis is defined as presence of endometrial glands and stroma located outside uterus. The most frequent extrauterine involvement is in pelvic viscera and periton. Extrapelvic endometriosis is a rare disease. Endometrial cells usually reach gynaecologic (vulva, vagen, servix) and non-gynaecologic (bowel, lung, skin, lymphatics, nerves and brain) areas via vascular or lyhmphatic dissemination. A 28-year old woman who became pregnant seven time, with no living child was admitted to the clinic with a history of painful lump in perineal region. She hadn't any concomitant disease. Her 6 pregnancy ended in fifth months of pregnancy. Her last pregnancy was 4 years before. She has received oral contraceptives for 3 years. On physical examination, there was a tender, immobile lump in 2 cm dimention located within the right mediolateral ephisiotomy scar tissue. Transvaginal ultrasonography revealed normal uterus and polycistic overs. CA-125 level was 47.8 U/ml (normal range, 0-35 U/ml). Following patient permission, this lesion was excised under local anesthesia, applied pathologic examination. Endometriosis should be kept in mind for the diagnosis of painful lumps of perineal region in women who had previous history of vaginal birth and ephisiotomy.
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