Effects of probiotic use on bacterial translocation in created rat models with biliary obstructions
Yükleniyor...
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Atatürk Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivs 3.0 United States
Attribution-NonCommercial-NoDerivs 3.0 United States
Özet
Objective: The aim of this study was to investigate the protective effects of the combined use of probiotic
strains on the development of bacterial translocation in addition to liver and intestinal tissue damage due to biliary obstruction in rats.
Materials and Methods: Here, 3 groups each consisting of 10 rats were created:group 1 (sham group),
group 2 (obstructive jaundice), and group 3 (obstructive jaundice+probiotic). Groups 1 and 2 were given 1
cc physiological saline solution by oral gavage twice a day; group 3 was given a probiotic solution that included Lactobacillus acidophilus, Lactobacillus rhamnosus, Bifidobacterium bifidum, Enterococcus faecium, and Bifidobacterium longum microorganisms by oral gavage twice a day.
Results: Markers for liver damage were also found to be significantly improved (p<0.05) in the treatment
group (group 3). Whencompared with groups 2 and 3 in terms of liver histology, damage was found to be
significantly more severe in group 2 (p<0.01). With regard to ileal villous depth and ileal inflammation, the
pathology was found to be significantly more severe in group 2 than that in group 3 (p<0.05). In blood,
spleen, and mesenteric lymph node cultures, group 2 showed a microbiological growth rate of 33.8–58.8%, whereas group 3 showed a microbiological growth rate of 14.3–28.6%. This reduction was evaluated to be statistically significant (p<0.05).
Conclusion: Our study showed that the combined use of a probiotic in bile duct obstructions reduced
bacterial translocation and alleviated pathological changes arising in the liver and terminal ileum histology
Açıklama
Anahtar Kelimeler
Bacterial translocation, Bile duct obstructions, Gram-negative microorganism, Combined use of probiotic microorganisms, Liver damage
Kaynak
The Eurasian Journal of Medicine
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
51
Sayı
2
Künye
Celikkaya, M. E., Akcora, B., Hakverdi, S., Ozer, B., Ulutas, K. T., & Duran, N. (2019). Effects of Probiotic Use on Bacterial Translocation in Created Rat Models with Biliary Obstructions. The Eurasian journal of medicine, 51(2), 106.
