Effects of probiotic use on bacterial translocation in created rat models with biliary obstructions

dc.authoridhttps://orcid.org/0000-0003-3324-4960en_US
dc.authoridhttps://orcid.org/0000-0003-3266-2562en_US
dc.authoridhttps://orcid.org/0000-0002-1845-6239en_US
dc.authoridhttps://orcid.org/0000-0001-8965-9335en_US
dc.authoridhttps://orcid.org/0000-0001-8965-9335en_US
dc.contributor.authorÇelikkaya, Mehmet Emin
dc.contributor.authorAkçora, Bülent
dc.contributor.authorHakverdi, Sibel
dc.contributor.authorÖzer, Burçin
dc.contributor.authorUlutaş, Kemal Türker
dc.contributor.authorDuran, Nizami
dc.date.accessioned2020-07-23T06:23:05Z
dc.date.available2020-07-23T06:23:05Z
dc.date.issued2019en_US
dc.departmentTayfur Ata Sökmen Tıp Fakültesien_US
dc.description.abstractObjective: The aim of this study was to investigate the protective effects of the combined use of probiotic strains on the development of bacterial translocation in addition to liver and intestinal tissue damage due to biliary obstruction in rats. Materials and Methods: Here, 3 groups each consisting of 10 rats were created:group 1 (sham group), group 2 (obstructive jaundice), and group 3 (obstructive jaundice+probiotic). Groups 1 and 2 were given 1 cc physiological saline solution by oral gavage twice a day; group 3 was given a probiotic solution that included Lactobacillus acidophilus, Lactobacillus rhamnosus, Bifidobacterium bifidum, Enterococcus faecium, and Bifidobacterium longum microorganisms by oral gavage twice a day. Results: Markers for liver damage were also found to be significantly improved (p<0.05) in the treatment group (group 3). Whencompared with groups 2 and 3 in terms of liver histology, damage was found to be significantly more severe in group 2 (p<0.01). With regard to ileal villous depth and ileal inflammation, the pathology was found to be significantly more severe in group 2 than that in group 3 (p<0.05). In blood, spleen, and mesenteric lymph node cultures, group 2 showed a microbiological growth rate of 33.8–58.8%, whereas group 3 showed a microbiological growth rate of 14.3–28.6%. This reduction was evaluated to be statistically significant (p<0.05). Conclusion: Our study showed that the combined use of a probiotic in bile duct obstructions reduced bacterial translocation and alleviated pathological changes arising in the liver and terminal ileum histologyen_US
dc.identifier.citationCelikkaya, M. E., Akcora, B., Hakverdi, S., Ozer, B., Ulutas, K. T., & Duran, N. (2019). Effects of Probiotic Use on Bacterial Translocation in Created Rat Models with Biliary Obstructions. The Eurasian journal of medicine, 51(2), 106.en_US
dc.identifier.doi10.5152/eurasianjmed.2019.18426en_US
dc.identifier.endpage111en_US
dc.identifier.issn1308-8734
dc.identifier.issue2en_US
dc.identifier.pmid31258347en_US
dc.identifier.scopus2-s2.0-85069531465en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage106en_US
dc.identifier.trdizinid333687en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/2912
dc.identifier.urihttps://dx.doi.org/10.5152/eurasianjmed.2019.18426
dc.identifier.volume51en_US
dc.identifier.wosWOS:000472088900002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherAtatürk Üniversitesien_US
dc.relation.ispartofThe Eurasian Journal of Medicineen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectBacterial translocationen_US
dc.subjectBile duct obstructionsen_US
dc.subjectGram-negative microorganismen_US
dc.subjectCombined use of probiotic microorganismsen_US
dc.subjectLiver damageen_US
dc.titleEffects of probiotic use on bacterial translocation in created rat models with biliary obstructionsen_US
dc.typeArticleen_US

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