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    Age-related changes in cat brains as demonstrated by histological and immunohistochemical techniques
    (Ecole Nationale Veterinaire Toulouse, 2010) Ozsoy, S. Y.; Haziroglu, R.
    The aim of the study was to investigate the brain pathological changes according to ageing in cats. For that, brains of 24 cats (over 10 years old) were compared with those of 8 younger cats (1-2 years old) using haematoxylin and eosin (HE), Periodic acid-Schiff (PAS) and von Kossa stains and immunohistochemical labelling for neuron-specific enolase (NSE), 2,3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), ubiquitin, glial fibrillary acidic protein (GFAP) and beta-amyloid protein (A beta). Cerebral and cerebellum atrophy with ventricular dilatation were observed for all aged cat brains. Histologically, these changes were frequently associated with fibrosis of meningeal vessels and hyalinosis of the choroid plexus, with neuronal degeneration (characterized by intense vacuolisation and swelling, white matter spongiosis, ubiquitin and NSE labelling and lipofuscinosis coupled to mineralization areas in the oldest cats) and also with severe gliosis (proliferation of Bergmann's glial cells and numerous positive GFAP and CNPase cells). Furthermore A beta deposits were mainly observed in vessel walls (in 91.7% of old cats) and as senile plaque (in 83.3% of cases). These age-related alterations of brain observed in cats were similar to those observed in humans and in other old mammals.
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    Öğe
    Evaluation of the age related changes in dog brains
    (Ecole Nationale Veterinaire Toulouse, 2010) Haziroglu, R.; Guvenc, T.; Tunca, R.; Ozsoy, S. Y.; Ozyildiz, Z.
    In this study it was aimed to compare the pathological findings on the brains of aged and young dogs. The research material consisted the brains of 20 dogs over 10 years old and brains of 10 dogs with an age of 1-2 years old. The brains were first of all examined macroscopically afterwards the tissue samples were taken from telencephalon, mesencephalon, rhombencephalon for histopathological and immunohistochemical investigations. In the aged dogs brains macroscopic examinations revealed meningeal thickness and ventricular dilatation. Microscopically, fibrosis at choroid plexus, meninges and vascular walls also ependymal defects, gliosis and neuronal depletion were observed in the aged dogs brains. On semi quantitative examination of the sections, a statistically significant increase on Glial Fibrillary Acidic Protein (GFAP) and 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNPase) expressions were determined in old dogs compared to young dogs (P<0.01).