Age-related changes in cat brains as demonstrated by histological and immunohistochemical techniques
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Dosyalar
Tarih
2010
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Ecole Nationale Veterinaire Toulouse
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of the study was to investigate the brain pathological changes according to ageing in cats. For that, brains of 24 cats (over 10 years old) were compared with those of 8 younger cats (1-2 years old) using haematoxylin and eosin (HE), Periodic acid-Schiff (PAS) and von Kossa stains and immunohistochemical labelling for neuron-specific enolase (NSE), 2,3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), ubiquitin, glial fibrillary acidic protein (GFAP) and beta-amyloid protein (A beta). Cerebral and cerebellum atrophy with ventricular dilatation were observed for all aged cat brains. Histologically, these changes were frequently associated with fibrosis of meningeal vessels and hyalinosis of the choroid plexus, with neuronal degeneration (characterized by intense vacuolisation and swelling, white matter spongiosis, ubiquitin and NSE labelling and lipofuscinosis coupled to mineralization areas in the oldest cats) and also with severe gliosis (proliferation of Bergmann's glial cells and numerous positive GFAP and CNPase cells). Furthermore A beta deposits were mainly observed in vessel walls (in 91.7% of old cats) and as senile plaque (in 83.3% of cases). These age-related alterations of brain observed in cats were similar to those observed in humans and in other old mammals.
Açıklama
Anahtar Kelimeler
Ageing, brain, cat, histopathology, immunohistochemistry, neuronal degeneration, gliosis
Kaynak
Revue De Medecine Veterinaire
WoS Q DeÄŸeri
Q4
Scopus Q DeÄŸeri
Cilt
161
Sayı
12
