Age-related changes in cat brains as demonstrated by histological and immunohistochemical techniques

Basit Öğe Kaydı
dc.contributor.authorOzsoy, S. Y.
dc.contributor.authorHaziroglu, R.
dc.date.accessioned2024-09-18T19:52:30Z
dc.date.available2024-09-18T19:52:30Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Ãœniversitesien_US
dc.description.abstractThe aim of the study was to investigate the brain pathological changes according to ageing in cats. For that, brains of 24 cats (over 10 years old) were compared with those of 8 younger cats (1-2 years old) using haematoxylin and eosin (HE), Periodic acid-Schiff (PAS) and von Kossa stains and immunohistochemical labelling for neuron-specific enolase (NSE), 2,3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), ubiquitin, glial fibrillary acidic protein (GFAP) and beta-amyloid protein (A beta). Cerebral and cerebellum atrophy with ventricular dilatation were observed for all aged cat brains. Histologically, these changes were frequently associated with fibrosis of meningeal vessels and hyalinosis of the choroid plexus, with neuronal degeneration (characterized by intense vacuolisation and swelling, white matter spongiosis, ubiquitin and NSE labelling and lipofuscinosis coupled to mineralization areas in the oldest cats) and also with severe gliosis (proliferation of Bergmann's glial cells and numerous positive GFAP and CNPase cells). Furthermore A beta deposits were mainly observed in vessel walls (in 91.7% of old cats) and as senile plaque (in 83.3% of cases). These age-related alterations of brain observed in cats were similar to those observed in humans and in other old mammals.en_US
dc.description.sponsorshipMKU BAP [08G0601]en_US
dc.description.sponsorshipThis research was supported by project MKU BAP (08G0601).en_US
dc.identifier.endpage548en_US
dc.identifier.issn0035-1555
dc.identifier.issn2258-0646
dc.identifier.issue12en_US
dc.identifier.startpage540en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7460
dc.identifier.volume161en_US
dc.identifier.wosWOS:000287897300002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherEcole Nationale Veterinaire Toulouseen_US
dc.relation.ispartofRevue De Medecine Veterinaireen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAgeingen_US
dc.subjectbrainen_US
dc.subjectcaten_US
dc.subjecthistopathologyen_US
dc.subjectimmunohistochemistryen_US
dc.subjectneuronal degenerationen_US
dc.subjectgliosisen_US
dc.titleAge-related changes in cat brains as demonstrated by histological and immunohistochemical techniquesen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
Ä°sim:
7460.pdf
Boyut:
1.31 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
Ä°ndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu