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Öğe Bir köşekte (C. dromedarius) nutrisyonel kardiyomiyopati(2016) Özdemir, Özgür; Çiftçi, Mustafa Kemal; Hatipoğlu, Fatih; Ortatatlı, Mustafa; Yavuz, Orhan; Kanat, ÖzgürBu çalışmada Türkiye'de ilk kez 1.5 aylık dişi bir köşekte (deve yavrusu) (C. dromedarius) nutrisyonel kardiyomiyopati olgusunun makroskobik ve mikroskobik bulguları tanımlandı. Konya ili, Karatay İlçe Belediyesi, Hayvanat Bahçesi'nde ölü olarak bulunan deve yavrusunun nekropsisinde, sol epikardda daha belirgin olmak üzere her iki ventrikül ile interventriküler septumda solgun, beyazımsı renkte alanlara rastlandı. Akciğerler oldukça hacimli ve koyu kırmızı renkte, trake ve bronşlarda köpüklü sıvı vardı. Mediastinal ve bron- şiyal lenf düğümlerinde büyüme, karaciğerde konjesyon ve tiroid bezinde büyüme gözlendi. Mikroskobik incelemede kalp kasında, hiyalin dejenerasyonu, zenker nekrozu ve yaygın kalsifikasyon, akciğerde konjesyon ile alveollerde yaygın ödem vardı. Karaciğerde hafif hiperemi, bağırsaklarda lamina epitelyaliste dejenerasyon ve deskuamasyon, propriyada nötrofil ve eozinofil granülosit infiltrasyonu gözlendi. Tiroid folliküllerinin epitellerinde hiperplaziye bağlı papiller uzantılar dikkati çekti. Bu bulgular ışığında deve yavrusunda ve/ veya annesindeki beslenme yetersizliği sonucunda beyaz kas hastalığı ve buna bağlı akciğerde dolaşım bozukluğu şekillendiği kanaatine varılarak, özellikle hayvanat bahçeleri gibi kapalı ortamlarda bakılan hayvanlara ilave vitamin ve mineral takviyesi yapılmasının uygun olacağı önerilmiştir.Öğe Effects of Adding Murt Volatile Oil (Myrtus Communis) to Japanese Quail Diets on Growth, Feed Consumption, Carcass, Some Blood and Tissue Characteristics in Lipopolysaccharide-Induced Inflammation(2022) Önel, Süleyman Ercüment; Alaşahan, Sema; Küçükgül, Altuğ; İşgör, Mehmet Mustafa; Kanat, Özgür; Hark, Betül DağoğluThis study, it was aimed to determine the effects of murt volatile oil added to the diet on Lipopolysaccharide (LPS) induced inflammation on body weight, feed consumption, feed conversion ratio, slaughter characteristics, some blood and organ parameters in quails. The study groups were formed as follows: control (commercial chick starter feed), M group (commercial chick starter + 200 mg/kg Murt volatile oil), MLPS group (commercial chick starter + 1 mg/kg-17th day and 7.5 mg/kg- 24th day intrabdominal LPS administered group) and LPS (commercial chick starter feed + 1 mg/kg 17th day and 7.5 mg/kg - 24th day intraabdominal LPS administered group). The study, 4 experimental groups consisting of 40 (4x10) quail chicks were formed and the fattening period lasted for 36 days. The study, blood and liver OSI (Oxidative stress index) values were found to be lower in the M and MLPS groups with murt supplementation than in the control groups without murt addition. During the study, the body weight value was determined lower in the groups with Murt added than in the groups without Murt addition. In addition, the feed conversion ratio was significantly better in the M group with murt supplementation between the 5th and 33rd days than in the other groups. Significant differences were determined between the groups in terms of gizzard ratio and chest+back+neck+wing ratio values. In the study, macroscopic and histopathological hyperemia was not observed in the small intestines, there was an increase in cell infiltration in other groups with added murt compared to the control group, and degeneration and necrosis of the epithelium were detected more prominently. In the study, it was determined that the addition of murt to quail compound feed had a positive effect on growth performance, feed consumption and feed efficiency.Öğe Histopathological and immunohistochemical findings in different tissues of goats infected with small ruminant lentivirus(2023) Kanat, Özgür; Ataseven, Veysel Soydal; Seçinti, İlke Evrim; İncecik, Veli; Doğan, FıratAim: Small ruminant lentivirus infections has chronic and incurable character that might simultaneously and immunopathogenically affect several major target organs, causing pathological and clinical mastitis, maedi, visna, and arthritis in sheep and goats. This study aimed to reveal the lesions and their cellular distribution in different tissues of histopathologically and immunohistochemically infected goats. Materials and Methods: A total of six goats, known as seropositive, and one aborted fetus, were used for the study. Histopathologic findings and immunohistochemical cellular distributions were determined. Results: Histopathologically, bronchopneumonia and chronic interstitial pneumonia, enteritis, hyaline droplets and hyaline cylinders, hydropic degeneration and necrosis of proximal and distal tubular epithelium in the kidneys, congestion and decrease of lymphoid cells in the spleen, congestion, hyaline degeneration and necrosis in the heart, and hydropic degeneration, necrosis and hepatitis in the liver were observed. Immunohistochemically, positive staining was observed in the epithelium of the bronchi and bronchioles, alveolar macrophages and lymphocytes in the lung, lymphocytes and macrophages in the spleen, crypt, and villous epitelium, lymphocytes and macrophages in the intestine, and Kupffer cells and lymphocytes in the liver. In contrast, no positivity was observed in the kidneys and heart. Conclusion: It is anticipated that the data obtained on small ruminant lentivirus infections will have an important place in goat breeding and will be important for new studies and control programs that may be developed.Öğe In vivo biocompatibility and fracture healing of hydroxyapatite-hexagonal boron nitridechitosan- collagen biocomposite coating in rats(TÜBİTAK, 2020) Yılmaz Deveci, Mehmet Zeki; Gönenci, Ramazan; Canpolat, İbrahim; Kanat, ÖzgürThe biocompatibility of orthopaedic implants and their effects on fracture healing have key roles for success. In this study, it was aimed to investigate the effects of a novel biocomposite consisting of hydroxyapatite (HA), hexagonal boron nitride (h-BN), chitosan (Cs), and type 1 collagen (Ct1) on biocompatibility and fracture healing in rats. A total of 60 adult male Wistar rats weighing 300–500 g were used in the study. The rats were randomly divided into 2 groups named A (uncoated/control) and B (biocomposite coated). Biocomposite (HA/h-BN/Cs/Ct1) coated and uncoated stainless-steel implants were used as intramedullary pins. Groups A and B were divided into subgroups of A1 and B1 (15th day), A2 and B2 (30th day), A3 and B3 (45th day) according to the date of euthanasia. Clinical, radiographic, haematological, biochemical, and histopathological findings were evaluated by pairwise comparisons. The findings were consistent and similar. No statistically significant difference was found for a finding disturbing the biocompatibility. Histopathological examinations showed that coating biomaterials did not resorb over the course of 15, 30, and 45 days. It is thus revealed that the content is biocompatible. However, it has been concluded that it is necessary to increase the physical strength of the coating surface against sterilization and surgical procedures. As a result, based on the interpretations of the clinical, radiographic, haematological, biochemical, and histopathological findings, the biocompatibility of HA/h-BN/Cs/Ct1 biocomposite materials has been revealed.Öğe In vivo biocompatibility and fracture healing of hydroxyapatite-hexagonal boron nitridechitosan-collagen biocomposite coating in rats(TÜBİTAK, 2020) Deveci, Mehmet Zeki Yılmaz; Gönenci, Ramazan; Canpolat, İbrahim; Kanat, ÖzgürThe biocompatibility of orthopaedic implants and their effects on fracture healing have key roles for success. In this study, it was aimed to investigate the effects of a novel biocomposite consisting of hydroxyapatite (HA), hexagonal boron nitride (h-BN), chitosan (Cs), and type 1 collagen (Ct1) on biocompatibility and fracture healing in rats. A total of 60 adult male Wistar rats weighing 300–500 g were used in the study. The rats were randomly divided into 2 groups named A (uncoated/control) and B (biocomposite coated). Biocomposite (HA/h-BN/Cs/Ct1) coated and uncoated stainless-steel implants were used as intramedullary pins. Groups A and B were divided into subgroups of A1 and B1 (15th day), A2 and B2 (30th day), A3 and B3 (45th day) according to the date of euthanasia. Clinical, radiographic, haematological, biochemical, and histopathological findings were evaluated by pairwise comparisons. The findings were consistent and similar. No statistically significant difference was found for a finding disturbing the biocompatibility. Histopathological examinations showed that coating biomaterials did not resorb over the course of 15, 30, and 45 days. It is thus revealed that the content is biocompatible. However, it has been concluded that it is necessary to increase the physical strength of the coating surface against sterilization and surgical procedures. As a result, based on the interpretations of the clinical, radiographic, haematological, biochemical, and histopathological findings, the biocompatibility of HA/h-BN/Cs/Ct1 biocomposite materials has been revealed.Öğe Molecular identification of bovine papillomaviruses in dairy and beef cattle: first description of Xi- and Epsilonpapillomavirus in Turkey(2016) Ataseven, Veysel Soydal; Kanat, Özgür; Ergün, YaşarIn the current study, 23 papilloma/tumor-like samples obtained from cattle having clinical lesions and 9 blood samples collected from healthy-appearing cattle in Turkey were examined for bovine papillomavirus (BPV) DNA using the degenerate primers FAP59/64, and the different types of BPV were distinguished by type-specific primer sets. Furthermore, histopathological studies of papillomavirus were performed. A total of 7 BPV types (BPVs 1, 2, 3, 4, 6, 8, 9), including genera Deltapapillomavirus, Xipapillomavirus,and Epsilonpapillomavirus, were identified. In all samples, BPV-1 was the most common genotype (90.6%). Overall, coinfections were determined in 26 of the examined samples (81.3%), and coinfection with BPV-1/BPV-4/BPV-8 (21.9%) was the most frequently identified using BPV type-specific primers. Moreover, bovine leukemia virus, an oncogenic retrovirus, was detected from three cattle with tumor-like lesions (13.0%), which were also coinfected by different BPV types. Histopathologically, nine papilloma-like lesions were assessed and diagnosed as five fibropapillomas and four papillomas. BPV infection is an important cause of economic losses in the dairy and beef industry. Our study will be highly useful for guiding further large-scale epidemiological studies and providing detailed data on the risk factors associated with BPV infection in cattle populations in Turkey.Öğe Nutritional muscular dystrophy in broiler thigh muscles: pathological analysis of a problem in the field(Biblioteca Universidad de Cordoba, 2022) Kanat, Özgür; Çerçi, Ibrahim HalilObjective. This study aims to use histopathologic method to investigate nutritional muscular dystrophy in broilers due to vitamin E deficiency. Materials and methods. Tissue samples taken from 20 dead chicks and total 28 blood samples sent by taking from diseased also eight chicks were analyzed. The amount of vitamin E determined in feed analysis was found to be 5% less than the amount declared to be present in the feed ration. Results. The average amount of ?-tocopherol in blood serums was measured as 0.285 ?g/g. Plasma calcium and phosphorus levels were found to be high, whereas sodium, potassium, and magnesium levels were found to be normal levels. Histopathologically, nutritional muscular dystrophy was defined in 18 of 20 chicks (90%). In the histopathologic examination of muscular sections, varying degrees of hyaline degenerations, necrosis, mineralization, lipidosis, and mononuclear cell infiltrations were observed. Conclusions. It was determined that when the fat content of the ration was increased, vitamin and mineral levels, particularly vitamin E, changed within the ration content, and the health of the chicks deteriorated, resulting in histopathologic damages in different organ tissues. The study concludes that the poultry farming industry should attach importance to feed management systems for chick’s the proper and healthy feeding. © The Author(s) 2021. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/), lets others remix, tweak, and build upon your work non-commercially, as long as they credit you and license their new creations under the identical terms.Öğe Şap Hastalığı(2015) İnce, Ömer Barış; Kanat, ÖzgürŞap hastalığı, yalnızca çift tırnaklı hayvanları etkileyen bir hastalık olmayıp canlı hayvan ve hayvansal ürünlerin ticaretindeki uluslararası kısıtlamalar nedeniyle ekonomik önemide olan viral hastalıklardan birisidir. Şap virusunun etiyolojisi teşhis ve uygun aşıların üretiminde önemli bir etmendir. Hastalığın endemik olduğu ülkelerde uygun serotipte inaktif aşılarla koruyucu aşılamalar yapılmakta ve hastalığın prevalansının düşürülmesine yönelik önlemler alınmaktadır. Son yıllarda Şap hastalığının dünyada hızlı bir yayılım göstermesi ve çok sıkı tedbirler alan ülkelerde bile görülmesi, hastalığın epidemiyolojisinde her ülkeye özgü risk faktörlerinin belirlenmesinin önemini bir kez daha ortaya çıkarmıştır. Bu derlemede, Şap hastalığı virusunun etiyolojisi, Dünya'da ve Türkiye'de dağılımı, epidemiyolojisi, patogenezi, teşhis ve kontrolüne yönelik güncel bilgiler verildi.
