In vivo biocompatibility and fracture healing of hydroxyapatite-hexagonal boron nitridechitosan- collagen biocomposite coating in rats
Yükleniyor...
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
TÜBİTAK
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The biocompatibility of orthopaedic implants and their effects on fracture healing have key roles for success. In this study, it
was aimed to investigate the effects of a novel biocomposite consisting of hydroxyapatite (HA), hexagonal boron nitride (h-BN), chitosan
(Cs), and type 1 collagen (Ct1) on biocompatibility and fracture healing in rats. A total of 60 adult male Wistar rats weighing 300–500
g were used in the study. The rats were randomly divided into 2 groups named A (uncoated/control) and B (biocomposite coated).
Biocomposite (HA/h-BN/Cs/Ct1) coated and uncoated stainless-steel implants were used as intramedullary pins. Groups A and B were
divided into subgroups of A1 and B1 (15th day), A2 and B2 (30th day), A3 and B3 (45th day) according to the date of euthanasia. Clinical,
radiographic, haematological, biochemical, and histopathological findings were evaluated by pairwise comparisons. The findings were
consistent and similar. No statistically significant difference was found for a finding disturbing the biocompatibility. Histopathological
examinations showed that coating biomaterials did not resorb over the course of 15, 30, and 45 days. It is thus revealed that the content
is biocompatible. However, it has been concluded that it is necessary to increase the physical strength of the coating surface against
sterilization and surgical procedures. As a result, based on the interpretations of the clinical, radiographic, haematological, biochemical,
and histopathological findings, the biocompatibility of HA/h-BN/Cs/Ct1 biocomposite materials has been revealed.
Açıklama
Anahtar Kelimeler
Biomaterial, biocomposite, implant coating, boron nitride, electrophoretic deposition, experimental
Kaynak
Turkish Journal of Veterinary and Animal Sciences
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
44
Sayı
1
Künye
DEVECİ M, GÖNENCİ R, CANPOLAT İ, KANAT Ö (2020). In vivo biocompatibility and fracture healing of hydroxyapatite-hexagonal boron nitridechitosan- collagen biocomposite coating in rats. Turkish Journal of Veterinary and Animal Sciences, 44(1), 76 - 88. 10.3906/vet-1906-21
