In vivo biocompatibility and fracture healing of hydroxyapatite-hexagonal boron nitridechitosan- collagen biocomposite coating in rats

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dc.authorid0000-0002-9532-247Xen_US
dc.authorid0000-0002-4043-2612en_US
dc.authorid0000-0001-7196-5529en_US
dc.authorid0000-0002-9747-5496en_US
dc.contributor.authorYılmaz Deveci, Mehmet Zeki
dc.contributor.authorGönenci, Ramazan
dc.contributor.authorCanpolat, İbrahim
dc.contributor.authorKanat, Özgür
dc.date.accessioned2023-01-10T07:30:13Z
dc.date.available2023-01-10T07:30:13Z
dc.date.issued2020en_US
dc.departmentVeteriner Fakültesien_US
dc.description.abstractThe biocompatibility of orthopaedic implants and their effects on fracture healing have key roles for success. In this study, it was aimed to investigate the effects of a novel biocomposite consisting of hydroxyapatite (HA), hexagonal boron nitride (h-BN), chitosan (Cs), and type 1 collagen (Ct1) on biocompatibility and fracture healing in rats. A total of 60 adult male Wistar rats weighing 300–500 g were used in the study. The rats were randomly divided into 2 groups named A (uncoated/control) and B (biocomposite coated). Biocomposite (HA/h-BN/Cs/Ct1) coated and uncoated stainless-steel implants were used as intramedullary pins. Groups A and B were divided into subgroups of A1 and B1 (15th day), A2 and B2 (30th day), A3 and B3 (45th day) according to the date of euthanasia. Clinical, radiographic, haematological, biochemical, and histopathological findings were evaluated by pairwise comparisons. The findings were consistent and similar. No statistically significant difference was found for a finding disturbing the biocompatibility. Histopathological examinations showed that coating biomaterials did not resorb over the course of 15, 30, and 45 days. It is thus revealed that the content is biocompatible. However, it has been concluded that it is necessary to increase the physical strength of the coating surface against sterilization and surgical procedures. As a result, based on the interpretations of the clinical, radiographic, haematological, biochemical, and histopathological findings, the biocompatibility of HA/h-BN/Cs/Ct1 biocomposite materials has been revealed.en_US
dc.identifier.citationDEVECİ M, GÖNENCİ R, CANPOLAT İ, KANAT Ö (2020). In vivo biocompatibility and fracture healing of hydroxyapatite-hexagonal boron nitridechitosan- collagen biocomposite coating in rats. Turkish Journal of Veterinary and Animal Sciences, 44(1), 76 - 88. 10.3906/vet-1906-21en_US
dc.identifier.doi10.3906/vet-1906-21en_US
dc.identifier.endpage88en_US
dc.identifier.issn1300-0128
dc.identifier.issn1303-6181
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85084000380en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage76en_US
dc.identifier.trdizinid334630en_US
dc.identifier.urihttps://dx.doi.org/10.3906/vet-1906-21
dc.identifier.urihttps://hdl.handle.net/20.500.12483/3406
dc.identifier.volume44en_US
dc.identifier.wosWOS:000513771900010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTÜBİTAKen_US
dc.relation.ispartofTurkish Journal of Veterinary and Animal Sciencesen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBiomaterialen_US
dc.subjectbiocompositeen_US
dc.subjectimplant coatingen_US
dc.subjectboron nitrideen_US
dc.subjectelectrophoretic depositionen_US
dc.subjectexperimentalen_US
dc.titleIn vivo biocompatibility and fracture healing of hydroxyapatite-hexagonal boron nitridechitosan- collagen biocomposite coating in ratsen_US
dc.typeArticleen_US

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