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Öğe Collagen Wound Dressings with Anti-Inflammatory Activity(Taylor & Francis Ltd, 2012) Albu, M. G.; Ferdes, M.; Kaya, D. A.; Ghica, M. V.; Titorencu, I.; Popa, L.; Albu, L.The aim of this study was to develop modern wound dressings such as controlled drug delivery systems. These systems consist in collagen as release support and niflumic acid as drug. The scaffolds were prepared by lyophilization in order to obtain porous structures and were evaluated by release profile of niflumic acid, water absorption, collagenase degradation and biocompatibility with fibroblast cells. The collagen scaffold with 0.75% niflumic acid solved in laurel oil was optimal in terms of biodegradability, absorbability and fibroblast cells biocompatibility. Thus, the obtained collagen scaffolds could be used as wound dressings with absorbent, antibacterial and anti-inflammatory properties.Öğe Effect of thyme oil (Thymbra spicata l. Var. Spicata) on meat quality in Japanese quails(Eugen Ulmer Gmbh Co, 2014) Aksu, T.; Aksu, M. I.; Onel, S. E.; Yakan, A.; Kaya, D. A.; Baylan, M.The effects of thyme oil on meat quality in Japanese quails were investigated. A total of 192 mixed sexes Japanese quail chicks were used in the feeding trial, which lasted until the birds reached 35 d of age. Birds were randomly allocated to 4 dietary treatments comprising three experimental groups and one control group (basal diet). Each group was divided into 4 subgroups, with each containing twelve quails. Basal diet was formulated according to NRC recommendations. Thyme oil was added daily to the basal diet at 200 (T1), 400 (T2) and 600 mg/kg (T3) levels, respectively. After slaughtering and evisceration, the carcasses were stored at 3 +/- 0.5 degrees C for 10-12 h and then the breast fillets were removed from carcass. All dietary levels of thyme oil increased significantly the pH values of the breast fillets (P < 0.01). Dietary thyme oils significantly affected the Thiobarbituric Acid Reactive Substances (TBARS) values. The TBARS value was significantly higher in male quails than in females (P < 0.01). Interaction between groups and gender has been significant for TBARS values and cold carcass weight (P < 0.01). The supplementation of thyme oil to diets significantly affected a* and C* values of breast fillets in Japanese quails (P < 0.01) while no differences were observed among all groups for L*, b*, H* values. Interaction between group and gender was also significant for a* and C* values (P < 0.01).Öğe EUCALYPTUS-COLLAGEN COMPOSITE GELS FOR DENTISTRY APPLICATIONS(Inst Materials Physics, 2014) Rusu, L. C.; Kaya, D. A.; Ghica, M. V.; Albu, M. G.; Popa, L.; Butu, A.; Dinu-Pirvu, C. E.Composite gels based on collagen and eucalyptus oil were prepared in order to be used in dentistry. The main components such as beta-Cymene (32.1%), Eucalyptol (36.59%), Cryptone (4.35%) and Spathulenol (3.82%) of Eucalyptus camadulensis Dehnh. essential oil were determined by GC-MS. The eucalyptus oil dissolved in different concentration of ethanol (4 and 8% v/v) was embedded in collagen gels (0.4 and 0.8% w/w) and crosslinked with tannic acid (0.2 and 0.4% w/w). The stability of gels was depending on collagen concentration, only the gels with 0.8% of collagen being stable. The rheological analysis of composite gels showed that formulation containing a combination of ethanol and tannic acid at the ratio of 8% v/v: 0.4% w/w resulted in the highest consistency index and yield stress. All the 0.8% collagen gels exhibited a suitable pseudoplastic behaviour and could be recommended for an adequate administration in the oral cavity.Öğe Lipid nanocarriers based on natural oils with high activity against oxygen free radicals and tumor cell proliferation(Elsevier Science Bv, 2015) Lacatusu, I.; Badea, N.; Badea, G.; Oprea, O.; Mihaila, M. A.; Kaya, D. A.; Stan, R.The development of nano-dosage forms of phytochemicals represents a significant progress of the scientific approach in the biomedical research. The aim of this study was to assess the effectiveness of lipid nanocarriers based on natural oils (grape seed oil, fish oil and laurel leaf oil) in counteracting free radicals and combating certain tumor cells. No drug was encapsulated in the nanocarriers. The cytotoxic effect exerted by bioactive nanocarriers against two tumor cells, MDA-MB 231 and HeLa cell lines, and two normal cells, L929 and B16 cell lines, was measured using the MTT assay, while oxidative damage was assessed by measuring the total antioxidant activity using chemiluminescence analysis. The best performance was obtained for nanocarriers based on an association of grape seed and laurel leaf oils, with a capacity to scavenge about 98% oxygen free radicals. A dose of nanocarriers of 5 mg.mL(-1) has led to a drastic decrease in tumor cell proliferation even in the absence of an antitumor drug (e.g. about 50% viability for MDA-MB 231 cell line and 60% viability for HeLa cell line). A comparative survival profile of normal and tumor cells, which were exposed to an effective dose of 2.5 mg.mL(-1) lipid nanocarriers, has revealed a death rate of 20% for normal B16 cells and of 40% death rate for MDA-MB 231 and HeLa tumor cells. The results in this study imply that lipid nanocarriers based on grape seed oil in association with laurel leaf oil could be a candidate to reduce the delivery system toxicity and may significantly improve the therapeutic efficacy of antitumor drugs in clinical applications. (C) 2015 Elsevier B.V. All rights reserved.
