Yazar "Kaya, Madalina Georgiana Albu" seçeneğine göre listele

Listeleniyor 1 - 7 / 7
  • Küçük Resim
    Öğe
    ANTI-INFLAMMATORY DRUG-LOADED BIOPOLYMERIC SPONGIOUS MATRICES WITH THERAPEUTIC PERSPECTIVES IN BURNS TREATMENT
    (Soc Stinte Farmaceutice Romania, 2018) Udeanu, Denisa Ioana; Kaya, Madalina Georgiana Albu; Ghica, Mihaela Violeta; Marin, Stefania; Marin, Maria Minodora; Kaya, Durmus Alpaslan; Popa, Lacramioara
    The most important goals of burns treatment suppose a fast skin regeneration to promote healing, the initial pain reduction and minimal scars forming. The development of new biopolymers-based wound dressings to ensure a proper healing process is nowadays a major challenge considering the incidence and consequences of burns. Our previously designed anti-inflammatory drug-loaded biopolymeric spongious matrices were initially tested by in vitro analysis and revealed proper morphological structure, swelling ability, degradation profiles and drug release patterns, indicating their potential use for burns treatment. Thus, the study aims to evaluate some collagen-sodium carboxymethylcellulose spongious matrices with or without mefenamic acid as non-steroidal anti-inflammatory drug in experimentally induced burns on Wistar rats, a frequently used animal model for the assessment of wounds healing. The treatment with the designed sponges promoted the wound healing compared to the classical treated control group. The sponges with mefenamic acid accelerated the healing process with a faster epithelial regeneration and a minimal scarring in comparison with the formulations containing no anti-inflammatory drug.
  • [ N/A ]
    Öğe
    Design and evaluation of new wound dressings based on collagen-cellulose derivatives
    (Elsevier Sci Ltd, 2023) Tudoroiu, Elena-Emilia; Kaya, Madalina Georgiana Albu; Titorencu, Irina; Dinu-Pirvu, Cristina Elena; Marin, Maria Minodora; Rosca, Ana-Maria; Popa, Lacramioara
    The purpose of this research was to design and characterize new hydrogels, respectively, their lyophilized forms, spongious matrices, based on collagen and methylcellulose or hydroxyethylcellulose to be used as wound dressings. 1.1% collagen gel was blended with 3% cellulose ethers gels in different ratios. To design the new potential dressings, we evaluated the compatibility of biopolymers through rheological and spectroscopic analyses for hydrogels, respectively spectral, morphological, goniometric, enzymatic, and thermal stability. Rheological measurements indicated that all hydrogels were pseudoplastic, a required property for their manipulation and application. Spectroscopic and spectral analyses showed the conservation of the specific triple helix structure of collagen for samples with 30% cellulose ethers. The morphological evaluation demonstrated that matrices presented hydrophilic and porous structures with proper swelling ability. The thermal and biodegradation study illustrated the increase of matrices' stability with the addition of cellulose ethers gels. Biocompatibility tests showed that none of the tested matrices had any cytotoxic effect and some compositions of collagen and methylcellulose or hydroxyethylcellulose release factors that might promote fibroblasts' proliferation and had no inhibitor effect on fibroblasts migration ability; all these results guarantee the development of a promising wound dressing based on 70% collagen gel and 30% cellulose ethers gels.
  • [ N/A ]
    Öğe
    DICLOFENAC SPONGIOUS MATRICES BASED ON COLLAGEN AND ALGINATE FOR RELIEVING INJURY PAINS
    (Incdtp-Icpi, 2018) Draghici, Roxana-Denisa; Marin, Maria Minodora; Ghica, Mihaela Violeta; Kaya, Madalina Georgiana Albu; Anuta, Valentina; Dinu-Pirvu, Cristina; Kaya, Durmus Alpaslan
    The sport injuries become more and more frequent so there is a need to discover new solutions for increasing the quality of life for people affected by such wounds. The aim of this study was to obtain a novel NSAID drug delivery system, topical diclofenac spongious matrices based on collagen and alginate for the treatment of injuries and relieving of pain. The samples were analyzed by flow analysis and after their freeze-drying were analyzed by FT-IR and in vitro release of sodium diclofenac.The results obtained from analyses confirmed that diclofenac spongious matrices based on collagen and alginate exhibit proper characteristics for the treatment of injuries and relieving of pain.
  • [ N/A ]
    Öğe
    In vitro cytotoxic activity of Nigella sativa L. On human malignant melanoma cell lines
    (Certex, INCDTP-ICPI, 2016) Duran, Nizami; Duran, Gulay Gulbol; Ay, Emrah; Kaya, Durmus¸ Alpaslan; Kaya, Madalina Georgiana Albu; Mert, Ahmet
    Nigella is a medicinal plant that has various pharmacological properties. It is widely used in folk medicine to treat many diseases in the world. It was aimed to investigate the essential oils Nigella sativa L. on two human melanoma cells (A-375 and A-2058 cell lines). In this study, two different cancer cell lines (A- 375and A-2058 cell lines) and one normal cell culture (vero cells) were used. Firstly, the non-toxic concentrations the essential oils of Nigella sativa L. were determined on normal cells (Vero cell line). And then, the cytotoxicity test were applied at these non-toxic concentrations. The cytotoxic activity of the essential oils of Nigella sativa L. on the cell lines was measured by MTT and Trypan blue assays. The chemical components analyses of the Nigella sativa L. oils were carried out by GC-MS. Medically important various components of Nigella sativa L. were determined in the GC-MS analysis. Some of these components are as follows; anethole (22.97%), thymoquinone (21.36%), a-thujene (6.22%), longifolene (5.76%), trans-isoeugenol (3.55%), carvacrol (2.23%). A total of 24 compounds were identified. The essential oils of Nigella sativa L. were found to inhibit the cell proliferation of human malignant melanoma cells. The IC50 values of the essential oils of Nigella sativa L. It were investigated as compared with a standard drug (methotrexate). Statistically significant decrease on the cell proliferations was found in the cells treated with the essential oils ofNigella sativa L. It was found to be non-toxic on normal cells (on Vero cell line) at the effective concentrations of the essential oils.While the non-toxic concentrations of essential oils on Vero cell line were found to be 12.5 ?g/ml, the effective concentrations for A-375 and A-2058 cell lines were as 1.56 ?g/ml and 3.12 ?g/ml, respectively. In conclusion, the essential oils of Nigella sativa L. were found to be significantly inhibited the cell proliferation on the human melanoma cells. The effect may arise from the components situated in the structure of Nigella sativa L. such asanethole, thymoquinone, a- thujene, longifolene, trans-isoeugenol and carvacrol. These components of this plant have been found promising in the treatment for human melanomas. But further studies, especially further animal studies should be needed to explain the action mechanisms of these components. © 2016 Certex, INCDTP-ICPI.
  • [ N/A ]
    Öğe
    Rheological Properties and Stability of Dermatocosmetic Emulsions with Collagen and Natural Ingredients Used as Color Correcting Cream and Cream Foundation
    (Revista Chimie Srl, 2019) Danila, Elena; Kaya, Durmus Alpaslan; Ghica, Mihaela Violeta; Kaya, Madalina Georgiana Albu; Negrea, Cristina; Popa, Lacramioara; Nitipir, Cornelia
    The aim of this study was to formulate and evaluate two types of 0/W emulsions based on collagen and other natural ingredients that can be used as color correcting (CC-cream) and cream foundation. Both types of emulsions obtained are stable at different temperatures and the pH values of emulsions correspond to the natural pH of the skin, indicating that emulsions can be safely applied to the skin. Results from the optical microscopy analysis show that all emulsions present foam-like appearance. The rheological properties of emulsions were studied and it was proved that all emulsions present a non-Newtonian pseudoplastic behaviour and thixotropic characteristics at two operating temperatures (24 and 33 degrees C). It can be concluded that all emulsions can be used as a natural alternative to a CC-cream or a cream foundation. Further microbiological tests and clinical trials are necessary for the obtained emulsions.
  • [ N/A ]
    Öğe
    Rheological properties and stability of dermatocosmetic emulsions with collagen and natural ingredients used as color correcting cream and cream foundation
    (Syscom 18 SRL, 2019) Danila, Elena; Kaya, Durmus Alpaslan; Ghica, Mihaela Violeta; Kaya, Madalina Georgiana Albu; Negrea, Cristina; Popa, Lacramioara; Nitipir, Cornelia
    The aim of this study was to formulate and evaluate two types of O/W emulsions based on collagen and other natural ingredients that can be used as color correcting (CC-cream) and cream foundation. Both types of emulsions obtained are stable at different temperatures and the pH values of emulsions correspond to the natural pH of the skin, indicating that emulsions can be safely applied to the skin. Results from the optical microscopy analysis show that all emulsions present foam-like appearance. The rheological properties of emulsions were studied and it was proved that all emulsions present a non-Newtonian pseudoplastic behaviour and thixotropic characteristics at two operating temperatures (24 and 33°C). It can be concluded that all emulsions can be used as a natural alternative to a CC-cream or a cream foundation. Further microbiological tests and clinical trials are necessary for the obtained emulsions. © 2019 SYSCOM 18 S.R.L.. All rights reserved.
  • [ N/A ]
    Öğe
    Synergistic activities of the essential oils Hypericum perforatum with methotrexate on human breast cancer cell line MCF-7
    (Certex, INCDTP-ICPI, 2016) Duran, Gulay Gulbol; Duran, Nizami; Ay, Emrah; Kaya, Durmus Alpaslan; Kaya, Madalina Georgiana Albu
    Hypericum perforatum (Hypericaceae) is a perennial plant usually known as “Sarikantaron“ that has been reported to have various important biological activities.In this present study, it was aimed to (I) identify the components (ii) show the synergistic activities of the essential oils Hypericum perforatum with methotrexate on human breast cancer cell line MCF-7. A normal [Madin-Darby Bovine Kidney (MDBK) cell line] and a cancer cell line [Human breast adenocarcinoma cell line (MCF-7)] were used in this study. The cell culture were treated with various concentrations of Hypericum perforatum's oils. The cytotoxic activity of the essential oils of Hypericum perforatum on the cell lines was measured using the MTT method and the results were evaluated as IC50. In this study, the presence of trans-caryophyllene, germacrene-D, ?-pinene, trans-cadina-1,4-diene, ?- Selinene, caryophyllene oxide and ?-Selinene were identified as major constituents of Hypericum perforatum's oils. The essential oils of Hypericum perforatum also exhibited anticancer activities against MCF-7 cells. The IC50 values of the essential oils, MTX and the essentialoilsplus MTX weredetermined as 0.78, 6.25 and 0.195 ?g/ml, respectively, But, the essential oils of Hypericum perforatum was found to be non-cytotoxic for MDBK cells. In conclusion, the essential oils of Hypericum perforatum was chemically characterized and ?-muurolene, ?-cadinene, germacrene B, a-copaene, germacrene D, bicyclogermacrene, and (E)-caryophyllene were found to be major constituents. The essential oils of Hypericum perforatum possess significant in vitro anticancer potential. The essential oils of Hypericum perforatum with MTX found to be significant effective against breast cancer cells. Further studies especially in vivo anticancer properties of Hypericum perforatum should be searched. These compounds found to be very promising compounds in the treatment of cancer therapy. © 2016 Certex, INCDTP-ICPI.