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Öğe The Antipsychotic Effects of Omega-3 Fatty Acids in Rats(Elsevier Science Inc, 2015) Kokacya, Mehmet Hanifi; Inanir, Sema; Copoglu, Umit Sertan; Dokuyucu, Recep; Erbas, OytunBackground: In humans, omega-3 fatty acids are necessary for cell membranes, brain function and nerve transmission continuation. When animals are exposed to a new environment-or as a result of an apomorphine application that creates an agonistic effect on D1 and D2 receptors-they display behavioral reactions like rearing and stereotypy. This study aims to reveal the possible antipsychotic and oxidative effects of omega-3 fatty acids by comparing with chlorpromazine, a conventional antipsychotic drug, through evaluating the novelty-induced rearing and apomorphine-induced stereotypic behaviors, as well as malondialdehyde and glutathione levels in rats. Methods: Twenty-eight, adult, male, Wistar rats were used in the study. Briefly, 4 groups of rats (n = 7) were administered docosahexaenoic acid (DHA) + eicosapentaenoic acid (EPA) (300 mg/kg; DHA: 120 mg/kg + EPA: 180 mg/kg intraperitoneally [IP]), DHA + EPA (150 mg/kg; DHA: 60 mg/kg + EPA: 90 mg/kg IP), chlorpromazine (1 mg/kg, IP) and isotonic saline (1 mL/kg, IP). One hour later, apomorphine (2 mg/kg, subcutaneously) was administered to each rat. After the apomorphine administration, rats were observed for stereotypic behavior. Results: This study shows that omega-3 fatty acids, similar to antipsychotics, reversed the psychotic like effects, increase of oxidants and decrease of antioxidants that are composed experimentally in rats. Conclusions: The application of omega-3 fatty acids has antipsychotic effects and causes an oxidative imbalance. This study adds new evidence to the current literature regarding the possible antipsychotic effects of omega-3 fatty acids.Öğe Anxiety, depression and quality of life in patients with beta thalassemia major and their caregivers(E-Century Publishing Corp, 2014) Yengil, Erhan; Acipayam, Can; Kokacya, Mehmet Hanifi; Kurhan, Faruk; Oktay, Gonul; Ozer, CahitMental health and health related quality of life is commonly affected in patients with chronic problems and their caregivers. In the present study, it was aimed to assess depression and anxiety in patients with beta thalassemia major (BTM) and in their caregivers; and to evaluate effects of these disorders on quality of life. The study was carried out in a district Hereditary Hemoglobinopathy Center and included 88 patients with BTM and 63 of their caregivers. All subjects were assessed using Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI) and Short Form-36 (SF-36) by a trained psychiatry resident via face-to-face interview. The BDI scores were 17 or above in 20.5% of the patients with BTM and 28.6% of their caregivers (P = 0.248). Of the patients with BTM, there were mild anxiety symptoms in 19.3%, while moderate and severe anxiety symptoms in 14.8% and 4.5%, respectively. Anxiety levels were similar between the patients with BTM and their caregivers (P = 0.878). It was found that BDI and BAI scores were negatively correlated to scores of physical health and mental health components of SF-36 in patients with BTM and their caregivers. In linear regression analysis, it was seen that depression affected physical and mental health of the patients with BTM and their caregivers regardless from anxiety. BTM leads an increase in the frequency of depression and anxiety in both patients and their caregivers, and affects negatively physical and mental components of quality of life.Öğe A Case of Cannabis Use-Associated Psychotic Disorder Accompanied by Autoscopic Phenomena(Turkish Green Crescent Soc, 2015) Kokacya, Mehmet Hanifi; Copoglu, Umit Sertan; Sahpolat, Musa; Ari, MustafaCannabis (Marijuana) is one of the most commonly used illegal addictive substances. The psychiatric symptoms associated with cannabis use are agitation, insomnia, depressive or raised mood, anxiety, hallucinations, and concentration problems. It is known that cannabis use increases the risk for psychoses and bipolar disorders and may deteriorate the clinical presentation of pre-existing psychoses and bipolar disorders. A characteristic symptom of autoscopic psychosis is visual hallucination of some part or the entirety of a person's body, imitating his or her behaviors and being perceived as if seen in a mirror. This is not a specific symptom of any mental disorder and the cause is not definitively known. In this case presentation, the symptoms of a patient diagnosed with cannabis use-associated autoscopic psychosis are discussed in the context of the literature.Öğe Demodex Parazytes in Schizophrenia(Derman Medical Publ, 2016) Kokacya, Mehmet Hanifi; Hamamci, Berna; Copoglu, Umit Sertan; Kaya, Ozlem AycanAim: Demodex parazytes are commonly present all over the world, especially in facial region of humans. Demodex spp. are assumed to be more common in schizophrenia due to partial suppression of immune system and lack of good self-care. The present study aimed to investigate the prevalence of Demodex ectoparasites in schizophrenia patients. Material and Method: In the study, 31 patients with a diagnosis of schizophrenia and 30 subjects without any psychiatric disorder or skin disease were subjected to standard superficial skin biopsy technique to determine Demodex spp. Results: Demodex spp. were found positive in nine schizophrenia patients and it was found positive in two healthy controls. Considering the prevalence of Demodex spp., a significant relationship is found between schizophrenia patients and normal controls (p< 0.05). Discussion: As a result, Demodex spp. are more common in schizophrenia due conditions of reduced self-care and immunosuppression, Demodex parasites should be considered in schizophrenia patients with skin lesions, especially on the face, and should to be treated if needed.Öğe Depression and Neglect of a Girl Child Due to Baby Boy Pressure of the Society(Cukurova Univ, Fac Medicine, 2015) Kokacya, Mehmet Hanifi; Copoglu, Umit Sertan; Demirkiran, Sumeryra Dua; Arslan, Mustafa MuhammetIn the present study, a condition of a major depressed mother who had three daughters and evidently neglect her daughters because of the pressure by the society and her relatives is presented. Our case is a 28-years old housewife with secondary school degree. She was admitted to our clinic with the symptoms of anhedonia, fatigue, unwillingness, crying and suicidal thoughts. She was hospitalized to psychiatric service with diagnosis of major depression because of the obvious symptoms of suicidal plans and motor retardation. It was understood that the last depression episode was experienced by her two years ago when she learned her child's sex form the gynecologist during her pregnancy. She stated that her husband's family wanted baby boy and blamed herself because she had failed to do so. Then, she started to neglect her girls after that time. She also stated that her care was reduced during her pregnancy and even she started to dress her children finer at cold weather and did not cover them at cold nights and did not give their medications to make them more and more ill. Also, said I wish my daughters die and I have a baby boy. Sex discrimination reduces the care that should be shown to girls. Our case wanted to harm her children because of the sex discrimination and ignored her daughters with the hope of having a baby boy.Öğe The effect of social support and severity of the disease on posttraumatic growth in ankylosing spondylitis(Acta Medica Mediterranea, 2014) Yagiz, Abdullah Erman; Kokacya, Mehmet Hanifi; Copoglu, Umit Sertan; Uruc, Vedat; Paksoy, Hacer; Yengil, Erhan; Ustun, NilgulAim: Posttraumatic growth (PTG) is described as the positive psychological changes after struggling with highly challenging life circumstances. This study aimed to evaluate PTG in patients with ankylosing spondylitis (AS) who were characterised with posture and joint motion disorders. The clinical and social factors that play a role in the development of PTG were also investigated. Materials and methods: Eighty AS patients aged 18 to 65 years were included in the study. Disease activity was evaluated by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), functional status by the Bath Ankylosing Spondylitis Functional Index (BASFI) and spinal mobility by the Bath Ankylosing Spondylitis Metrology Index (BASMI). For the evaluation of the positive psychological changes posttraumatic growth inventory (PTGI) was used, as multidimensional scale of perceived social support (MSPSS) and ways of coping inventory were respectively used to assess social support and coping strategies. Results: The population consists of 58 male and 22 female subjects. The mean total scores of PTG, total social support and coping inventory were 67.90 ± 18.96, 66.42 ± 14.52 and 96.97 ± 10.43, respectively. The total PTG scores were significantly higher in women than in men (p=0.016). BASDAI and BASFI were negatively correlated with PTG, whereas ways of coping and social support were positively correlated with PTG (p=0.001, r=0.352; p=0.044, r=0.226). Conclusion: Social support and ways of coping have a positive effect, whereas disease severity and poor functional index have a negative effection the development of PTG.Öğe THE EFFECT OF SOCIAL SUPPORT AND SEVERITY OF THE DISEASE ON POSTTRAUMATIC GROWTH IN ANKYLOSING SPONDYLITIS(Carbone Editore, 2014) Yagiz, Abdullah Erman; Kokacya, Mehmet Hanifi; Copoglu, Umit Sertan; Uruc, Vedat; Paksoy, Hacer; Yengil, Erhan; Ustun, NilgulAim: Posttraumatic growth (PTG) is described as the positive psychological changes after struggling with highly challenging life circumstances. This study aimed to evaluate PTG in patients with ankylosing spondylitis (AS) who were characterised with posture and joint motion disorders. The clinical and social factors that play a role in the development of PTG were also investigated. Materials and methods: Eighty AS patients aged 18 to 65 years were included in the study: Disease activity was evaluated by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), functional status by the Bath Ankylosing Spondylitis Functional Index (BASFI) and spinal mobility by the Bath Ankylosing Spondylitis Metrology Index (BASMI). For the evaluation of the positive psychological:changes posttraumatic growth inventory (PTGI),Was used as multidimensional scale of perceived octal support (MSPSS) and ways of coping inventory were respectively used to assess social support and coping strategies. Results: The population consists of 58 male and 22 female subjects. The Mean total scores of PTG, total social support and coping inventory were 67.90 +/- 18.96, 66.42 +/- 14 52 and 96.97 +/- 10.43, respectively. The total PTG scores were significantly higher in Women than in men (p=0.016). BASDAI and BASFI were negatively correlated with PTG, whereas ways of coping and social supF port were positively correlated with PTG (p=0.001, r=0352; p=0.44, r=0226). Conclusion: Social support and ways of coping have a positive effect, whereas disease severity and poor functional index have a negative effection the development of PTG:Öğe The evaluation of anxiety and panic agarophobia scores in patients with benign paroxysmal positional vertigo on initial presentation and at the follow-up visit(Taylor & Francis Ltd, 2017) Kahraman, Serif Samil; Arli, Cengiz; Copoglu, Umit Sertan; Kokacya, Mehmet Hanifi; Colak, SaitConclusion: Patients with BPPV experienced short but intense anxiety and/or panic disorder, especially at the initial visit, but most patients recovered without medication with successful treatment. Objective: Recent studies have shown that people with dizziness report some psychological problems such as panic and agoraphobia and anxiety. The aim of this study was to evaluate anxiety and panic agorophobia levels in patients with benign paroxysmal positional vertigo on initial presentation and at the follow-up visit and compare the scores with the control group. Methods: All the 32 patients in the study had a diagnosis of BPPV confirmed by their history, typical subjective symptom reports, and characteristic positional nystagmus during the Dix-Hallpike test and/or Roll test. The patients were instructed to complete the standard forms of Beck anxiety inventory and panic agoraphobia scale questionnaire before and at 7 and 14 days after the canalith repositioning treatment. Results: The validity scores of panic agoraphobia were statistically significantly higher in patients with BPPV than in the control group in each period (p < .001) and the validity scores of the Beck anxiety inventory were statistically significantly higher in patients with BPPV than in the control group at the first and second evaluation (p < .001).Öğe First manic episode induced by over the counter slimming drug that contains sibutramine(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2014) Kokacya, Mehmet Hanifi; Sahpolat, Musa; Kurhan, FarukSibutramine, a serotonin, noradrenalin and to a lesser extent dopamine reuptake inhibitor, is a beta phenyletylamine used in obesity treatment and has many psychiatric side effects. Although, prohibited due to cardiologic side effects, it is still being sold as Slimming pills via internet. It is known that antidepressants can cause manic or hypomanic shifts. Since sibutramine has an antidepressant activity it may cause manic or hypomanic shifts. We present an adolescent who had his first manic episode after using sliming pills, which contain sibutramine, and was admitted to our service for his second manic episode 6 months after his first episode.Öğe Increased Mean Platelet Volume in Patients with Depression(Derman Medical Publ, 2015) Kokacya, Mehmet Hanifi; Copoglu, Umit Sertan; Ari, Mustafa; Sahpolat, Musa; Ulutas, Kemal Turker; Kivrak, YukselAim: It is well known that the mean platelet volume (MPV) is a good indicator of platelet activity and the incidence of cardiovascular diseases. Major depressive disorder may emerge in association with the cardiovascular diseases. In this study, we aimed to investigate the relationship between MPV and major depressive disorder. Material and Method: MPV values of 65 patients with major depression were compared with 66 age-and sex-matched healthy subjects. Body mass index (BMI), MPV, platelet count (PLC) of all participants were measured. Beck Depression Scale (BDS) was performed to measure severity of depression. Results: MPV values of patients who had major depression were found to be significantly higher than the control group. Comparing Major Depression with the control group, there was no significant difference in terms of platelet count. In the depression group, there was no correlation between the severity of depression and MPV. Discussion: As a result, the mean platelet volume was determined to have a significant increase in major depressive disorder compared with healthy individuals. This also may be informative about the association between pathologies related vascular structure such as vascular atherosclerosis and depression.Öğe Increased mean platelet volume in patients with panic disorder(Dove Medical Press Ltd, 2015) Kokacya, Mehmet Hanifi; Copoglu, Umit Sertan; Kivrak, Yuksel; Ari, Mustafa; Sahpolat, Musa; Ulutas, Kemal TurkerObjective: The relationship between platelet activation and psychiatric disorders has been shown in previous work. Mean platelet volume (MPV) is a measure of platelet size and a good indicator of platelet activity, which increases in cardiovascular diseases (CVDs). It is known that anxiety is a considerable factor in the etiology of mortality in CVDs. The aim of the present study was to investigate any probable difference in the MPV of patients with panic disorder (PD). Methods: Sixty-one drug-free patients, aged 18-65 years and diagnosed with PD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, were included in the study, along with 63 healthy age-and sex-matched volunteers. The body mass index (BMI) was calculated and MPV measured for each subject. Results: The MPV was found to be higher in the PD group compared to the control group (P=0.004). There were no significant differences between the two groups in terms of platelet count or BMI. Conclusion: Alterations in platelet activity may be a reflection of abnormal 5-hydroxytryptamine (5-HT) 1A receptor function in the central nervous system of subjects with a diagnosis of PD. These findings may elucidate the relationship between CVDs and PD. The findings of the present study suggest that MPV is increased in PD patients.Öğe Optical Coherence Tomography Angiography in Schizophrenia(Aves, 2022) Kokacya, Mehmet Hanifi; Cakmak, Ayse IdilObjective: The aim of this study is to investigate the retinovascular structure of schizophrenia patients using optical coherence tomography angiography (OCTA). Methods: 47 eyes of schizophrenia patients were compared with 50 eyes of demographically matched healthy controls in terms of OCTA measurements. Schizophrenia patients were evaluated in two groups as short-term (<= 5years) and long-term (> 5years) according to the time elapsed after the diagnosis of schizophrenia. Results: Schizophrenia patients showed overall thinning of retinal nerve fiber layer and macula, and lower vessel density (VD) compared to controls. The results were significant for thickness measurements of general macula and for VD in specific areas (P <0.05); however, they were not significant for the RNFL measurements except the mean circum-papillary RNFL, which was noted to approach significance (P = 0.055). Long-term patients showed significantly lower VD in the whole and perifoveal region of superficial capillary plexus, the whole, perifoveal and foveal region of deep capillary plexus, and the whole area and the disc of radial peripapillary capillaries compared to short-term patients (P= 0.014, P= 0.009, P=0.011, P= 0.010, P=0.011, P= 0.035, P= 0.030). Conclusions: These findings suggest that schizophrenia may be a neurodegenerative disease with progressive microvascular involvement over the years, and that OCTA has the potential to be a useful tool in detecting retinovascular changes in patients with schizophrenia.Öğe Partner violence against women, childhood trauma, depression and quality of life: a population based-study(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2015) Kivrak, Yuksel; Gey, Neriman; Kivrak, Habibe Ayla; Kokacya, Mehmet Hanifi; Copoglu, Umit Sertan; Ari, MustafaObjective: In this study our aim was to investigate the frequency of spousal violence, its relationship with childhood traumas, depression and sociodemographic factors and its effects on affected women's life quality. Methods: Data of 410 randomly chosen people who live in the city center and nearby villages were evaluated. The sociodemographic data survey, Short Form 36 (SF- 36), Family Violence Survey (FVS), Beck Depression Scale (BDS), Childhood Trauma Scale (CTS) were applied. Results: Of the participants, 366 (89.3%) had experienced violence at least once in their lifetime. 309 (75.4%) of them were emotional, 306 (74.6%) of them were sexual, 285 (69.5%) of them were verbal, 222(54.1%) of them were physical, 321 (78.3%) of them were economical violence. Beck Depression Scale, Childhood Trauma Scale, husband's educational level, disparity in age and education level between spouses were important for exposure to violence. Depression was an important effect on life quality of the affected women. Conclusion: Familial violence is frequent. BDS, CTS are the main predictors for spousal violence and life quality. Diagnosis and treatment of depression may help to prevent spousal violence and increase life quality.Öğe Plasma Apelin, Visfatin and Resistin Levels in Patients with First Episode Psychosis and Chronic Schizophrenia(Korean Coll Neuropsychopharmacology, 2020) Sahpolat, Musa; Ari, Mustafa; Kokacya, Mehmet HanifiObjective: This study aims to investigate the possible relationship between plasma concentrations of apelin, visfatin and resistin levels of first episode psychosis patients and chronic schizophrenia patients. Methods: A total number of 29 untreated patients with first episode psychosis, 30 chronic schizophrenia and 29 randomly selected weight- and body mass index-matched healthy volunteers were included. The Diagnostic and Statistical Manual of Mental Disorders 4th edition, Positive and Negative Syndrome Scale (PANSS) and Clinical Global Impression Scale were applied to the patient groups. The enzyme-linked immunosorbent assay method was used to measure plasma apelin, visfatin and resistin levels. Results: There was no difference in age, marital status, occupation, and BMI between the groups. Plasma apelin levels were significantly higher in first episode psychosis group than chronic schizophrenia and control group. There was no statistically significant difference in plasma visfatin levels between the groups: first episode psychosis group, chronic schizophrenia and control group. Plasma resistin levels were higher in both first episode psychosis group and chronic schizophrenia group than the control group. There was no statistically significant correlation between plasma apelin and resistin levels and total PANSS scores in the group of patients. Conclusion: To our knowledge, this study is the first which investigates the plasma apelin, visfatin and resistin levels in patients with first episode psychosis and chronic schizophrenia. Based on the results of this study, apelin and resistin may be related with some central nervous system pathologies, including the severity of a psychiatric disorder.Öğe Prevalence of Demodex spp among alcohol-dependent patients(Cukurova Univ, Fac Medicine, 2016) Kokacya, Mehmet Hanifi; Kaya, Ozlem Aycan; Copoglu, Umit Sertan; Elmacioglu, SibelPurpose: Demodex folliculorum and Demodex brevis are common ectoparasites found in humans and live on the pilosebaceous glands and hair follicles especially on the facial region. Chronic alcohol consumption can weaken immune system and cause more severe infections. Demodex spp is assumed to be more common in alcohol-dependent patients due to partial suppression of immune system and lack of good self-care. The present study aims to investigate the prevalence of Demodex spp. ectoparasite in alcohol-dependent patients. Material and Methods: In the study, 24 patients with a diagnosis of alcohol dependence and 24 healthy control subjects were subjected to standard superficial skin biopsy technique to determine Demodex spp. Results: In 37.5% of alcohol-dependent patients and 4.1% of control subjects Demodex spp. were found positive. Considering the prevalence of Demodex spp, a significant difference was found between alcoholdependent patients and control subjects. Conclusion: Demodex spp. are more common in alcoholdependent patients due conditions of reduced self-care and immunosuppression. Demodex parasites should be considered in alcohol-dependent patients with skin lesions, especially on the face, and should to be treated if needed.Öğe Priapism induced with single dose 150 mg quetiapine(Cukurova Univ, Fac Medicine, 2021) Dogan, Gozde; Gulbol, Selin; Kokacya, Mehmet Hanifi[Abstract Not Available]Öğe Prolidase activity and oxidative stress in patients with major depressive disorder(Medicinska Naklada Zagreb, 2014) Kokacya, Mehmet Hanifi; Bahceci, Bulent; Bahceci, Ilkay; Dilek, Aziz Ramazan; Dokuyucu, RecepBackground: The aim of the current study was to determine whether the serum prolidase levels are associated with the etiopathogenesis of depression. Subjects and methods: This study included 29 patients with major depressive disorder (MDD), who were consecutively recruited from the psychiatric outpatient clinic, and 30 healthy individuals recruited from the general community. Each patient underwent a detailed diagnostic evaluation by two psychiatrists using the Structured Clinical Interview for DSM-IV (SCID-I). Serum prolidase activity and oxidative parameters were measured in the patient and control groups. The severity of depressive symptoms was assessed using the Hamilton Depression Rating Scale. Results: Serum prolidase level was significantly higher in patients with MDD compared to healthy subjects (p<0.001). Total Oxidant Status (TOS) levels and Oxidative Stress Index (OSI) were also significantly higher in patients with MDD (p<0.001), whereas no significant difference was observed between the groups in the TAS levels (p=0.297). Serum prolidase level did not show any correlation with markers of oxidative stress in patients with MDD. Conclusion: Increased serum prolidase levels in patients with MDD may be interpreted as the interaction of prolidase activity, glutamate transmission and oxidative stress. It is suggested that prolidase activity is involved in the etiopathogenesis of depressive disorder. © Medicinska naklada - Zagreb, CroatiaÖğe PROLIDASE ACTIVITY AND OXIDATIVE STRESS IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER(Medicinska Naklada, 2014) Kokacya, Mehmet Hanifi; Bahceci, Bulent; Bahceci, Ilkay; Dilek, Aziz Ramazan; Dokuyucu, RecepBackground: The aim of the current study was to determine whether the serum prolidase levels are associated with the etiopathogenesis of depression. Subjects and methods: This study included 29 patients with major depressive disorder (MDD), who were consecutively recruited from the psychiatric outpatient clinic, and 30 healthy individuals recruited from the general community. Each patient underwent a detailed diagnostic evaluation by two psychiatrists using the Structured Clinical Interview for DSM-IV (SCID-I). Serum prolidase activity and oxidative parameters were measured in the patient and control groups. The severity of depressive symptoms was assessed using the Hamilton Depression Rating Scale. Results: Serum prolidase level was significantly higher in patients with MDD compared to healthy subjects (p<0.001). Total Oxidant Status (TOS) levels and Oxidative Stress Index (OSI) were also significantly higher in patients with MDD (p<0.001), whereas no significant difference was observed between the groups in the TAS levels (p=0.297). Serum prolidase level did not show any correlation with markers of oxidative stress in patients with MDD. Conclusion: Increased serum prolidase levels in patients with MDD may be interpreted as the interaction of prolidase activity, glutamate transmission and oxidative stress. It is suggested that prolidase activity is involved in the etiopathogenesis of depressive disorder.Öğe Relationship between depression, anxiety, quality of life and vaso-occlusive crisis in adolescents with sickle cell disease(Acta Medica Mediterranea, 2014) Ozer, Cahit; Yengil, Erhan; Acipayam, Can; Kokacya, Mehmet HanifiAims: To explore the relationship between frequency of pain episodes and depression, anxiety, and health related quality of life (HRQOL) in adolescents with sickle cell disease (SCD). Materials and methods: Ten males and twelve females, between the ages of 12 and 19, selected during admittance to pediatric hematology outpatients of city hospital with a vaso-occlusive crisis in the period between September 2012 and February 2013, were included in the study. Beck Depression (BDI) and Anxiety Inventories (BAI), and Short Form Health Survey (SF-36) were used to evaluate depression, anxiety and HRQOL. Results: Nine (40.9%) of the adolescents with SCD had BDI scores higher or equal to 17. In the whole group, 3 (13.6%) patients did not have anxiety, while 14 (63.6%) of them had mild and 4 (18.2%) had moderate anxiety. Physical and mental components of HRQOL were not correlated to BDI and BAI scores. Patients with frequent pain episodes (>10 annually) were found to have tendency to depression and anxiety while their mental and physical components of HRQOL were lower than patients with infrequent pain episodes (<5 annually). Conclusion: Depression and anxiety in adolescents with SCD was found relatively high, while Physical and Mental components of HRQOL were relatively low. However, Physical and Mental Health of the patients was not affected from depression and anxiety presence. Pain episode frequency might be the main determinant of higher depression and anxiety and lower HRQOL component scores.Öğe RELATIONSHIP BETWEEN DEPRESSION, ANXIETY, QUALITY OF LIFE AND VASO-OCCLUSIVE CRISIS IN ADOLESCENTS WITH SICKLE CELL DISEASE(Carbone Editore, 2014) Ozer, Cahit; Yengil, Erhan; Acipayam, Can; Kokacya, Mehmet HanifiAims: To explore the relationship between frequency of pain episodes and depression, anxiety, and health related quality of life (HRQOL) in adolescents with sickle cell disease (SCD). Materials and methods: Ten males and twelve females, between the ages of 12 and 19, selected during admittance to pediatric hematology outpatients of city hospital with a vaso-occlusive crisis in the period between September 2012 and February 2013, were included in the study. Beck Depression (BDI) and Anxiety Inventories (BAI), and Short Form Health Survey (SF-36) were used to evaluate depression, anxiety and HRQOL. Results: Nine (40.9%) of the adolescents with SCD had BDI scores higher or equal to 17. In the whole group, 3 (13.6%) patients did not have anxiety, while 14 (63.6%) of them had mild and 4 (18.2%) had moderate anxiety. Physical and mental components of HRQOL were not correlated to BDI and BAI scores. Patients with frequent pain episodes (>10 annually) were found to have tendency to depression and anxiety while their mental and physical components of HRQOL were lower than patients with infrequent pain episodes (<5 annually). Conclusion: Depression and anxiety in adolescents with SCD was found relatively high, while Physical and Mental components of HRQOL were relatively low. However, Physical and Mental Health of the patients was not affected from depression and anxiety presence. Pain episode frequency might be the main determinant of higher depression and anxiety and lower HRQOL component scores.
