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Öğe Caffeic acid phenethyl ester decreases the level of S-100B protein after middle cerebral after occlusion in rabbits(2009) Serarslan, Yurdal; Bal, Ramazan; Altu?, Muhammed Enes; Kontaş, Tünay; Melek, Ismet MuratEffects of caffeic acid phenethyl ester (CAPE) on the serum S-100B levels were studied as an index for brain damage after permanent middle cerebral artery (MCA) occlusion in rabbits. Twenty rabbits were divided into four groups (n=5): control, sham, non-treatment and CAPE. The right MCA was occluded using a microsurgical procedure with bipolar coagulation and was then transected in non-treatment and CAPE groups. The rabbits in the sham group underwent a surgical procedure but the MCA was not occluded. No surgery was performed in the control group. CAPE was administered after MCA occlusion at the dose of 10?g/kg, once a day intraperitoneally for 7 days in the CAPE group. Serum S-100B levels were determined on days 1, 2, 4 and 7. Serum S-100B level was significantly increased following permanent MCA occlusion. Posttreatment of CAPE significantly reduced the serum S-100B level. This study demonstrated that CAPE is capable of attenuating increased serum S-100B level induced by MCA occlusion in rabbits. CAPE may be useful as a neuroprotective agent.Öğe Effect of caffeic acid phenethyl ester on plasma lipid peroxidation, antioxidant status and nitric oxide levels in incisional wound model(2007) Serarslan, Gamze; Altu?, Muhammed Enes; Kontaş, TünayBackground and Design: Wound healing is a complex pathophysiologic process involving interplay of several cellular and biochemical processes. Several natural products have been shown to accelerate the healing process in studies. In this study we aimed to determine the efficacy of caffeic acid phenethyl ester (CAPE), which is an extract of honeybee propolis on wound healing in rats. Materials and Methods: Fourty male Wistar albino rats were divided into two groups as treatment (n=20) and control (n=20) group. A linear full thickness incision was performed on the back of each rat and sutured. After incision, during the study period CAPE was administered to the treatment group and saline was administered to the control group every day. Bloods of 5 animals from each group were collected on the experiment days of 1st, 3rd, 7th and 14th for biochemical analysis. Results: A significant increase in glutathione and nitric oxide levels and a significant decrease in malondialdehyde levels and superoxide dismutase activities in CAPE group were detected when compared to the control group. Conclusion: In the study it determined that CAPE showed an antioxidant effect on wound healing and suppressed lipid peroxidation. In conclusion, because of these properties, CAPE may be useful in wound healing.Öğe Effects of caffeic acid phenethyl ester on renal damage in rabbits with partial ureteral obstruction(2009) Akçora, Bülent; Altu?, Muhammed Enes; Hakverdi, Sibel; Kontaş, Tünay; Öztürk, Atakan; Bayraktar, SuphiObstructive urologic diseases may cause renal injury related to intensty and duration of occlusion. In experimental studies, many pharmacological agents were used to decrease the harmful effects of obstruction on kidney. This study was designed to investigate effects of caffeic acid phenethyl ester (CAPE) on the parsial ureteral obstruction in rabbits. Twenty-one New Zealand rabbits were divided randomly into 3 groups each containing 7 animals. Group 1, 2 and 3 were defined as control (sham), partially obstructed, and partially obstructed plus CAPE treatment, respectively. All animals were sacrified at the end of 3 weeks. Malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD) and myeloperoxidase (MPO) levels were measured. In addition, kidney tissues stained with Hematoxylin-eosine were evaluated using Cleasson's histopathological criteria. MDA, NO and SOD levels were not significantly different among all groups. Mean MPO levels of groups 1, 2 and 3 were 0.22±0.07 U/g protein, 0.36±0.09 U/g protein, 0.27±0.10 U/g protein respectively. A significant increase was found in group 2 when compared to group 1(p<0.05). Kidneys of group 3 were significantly protected in terms of 2 out of 9 histopathologic criteria when compared to group 2 (p<0.05). There was significant difference between group 2 and group 3 in terms 2 out of 9 histopathologic criteria (p<0.05); injury of kidneys in group 3 was less than in group 2. MDA, NO and SOD levels which are used to detect renal injury in complete ureteral obstruction model, did not show any significant difference in partial obstruction model in our study. In the light of our biochemical and histopathologic findings, we can say that CAPE treatment has a tendency to decrease the degree of renal injury in the partial obtruction model. © 2009 OMÜ Tüm Haklari Saklidir.Öğe Hatay Bölgesinde merada yetiştirilen koyun ve keçi serumlarında bazı mineral madde düzeyleri(2002) Erdoğan, Suat; Ergün, Yaşar; Erdoğan, Zeynep; Kontaş, TünayThis study was carried out on 93 sheep and 92 goats which were all clinically healthy and raised in the pasture conditions in the Hatay region. Blood samples were collected from the jugular vein between June and July (1999) in Altınözü, Reyhanlı, Yayladağı, Samandağı and Dörtyol province. Serum samples were analysed by atomic absorption spectrophotometry for copper and zinc. Sodium and potassium levels were determined by flame photometry, calcium levels were quantified by Eppendorf photometry, magnesium was measured by spectrophotometry and selenium was determined by fluorometry. In the Hatay region, Mg 1.08$\pm$0.02 mmol/L, Ca 2.380$\pm$.06 mmol/L, Na 149.072$\pm$.06 mmol/L, K 3.050$\pm$.07 mmol/L, Cu 0.32$\pm$0.01 ppm, Zn 0.22$\pm$0.01 ppm and Se 0.120$\pm$.01 ppm were found in sheep; Mg 1.130$\pm$.02 mmol/L, Ca 2.110$\pm$.05 mmol/L, Na 149.372$\pm$.65 mmol/L, K 3.06$\pm$0.05 mmol/L, Cu 0.330$\pm$.02 ppm, Zn 0.210$\pm$.00 ppm and Se 0.160$\pm$.00 ppm were measured in goats. Calcium, Mg, Na and Se levels were found to be within the normal range in both sheep and goats. However, K levels were slightly lower in some regions, and Cu and Zn levels were under critical levels in all regions. It is concluded that Cu and Zn should be added to the rations of goats and sheep.Öğe Tavşanlarda rasyona ilave edilen farklı miktarlardaki Yucca Schidigera ekstraktının (de-odorase®) bazı serum makro ve mikro element düzeylerine etkisi(2007) Avcı, Gülcan; Küçükkurt, İsmail; Kontaş, Tünay; Eryavuz, Abdullah; Fidan, Abdurrahman FatihBu çalışmada tavşanların rasyonuna ilave edilen 100 ve 200 ppm düzeyindeki Yucca Shidigera (YS) ekstraktının serumdaki bazı makro ve mikro element düzeylerine etkisinin belirlenmesi amaçlandı. Çalışmada toplam 24 adet New Zeland tavşanı kullanıldı. Kontrol grup temel rasyon ile beslenirken, grup I ve II rasyonuna sırasıyla 100 ve 200 ppm YS ekstraktı (De-Odorase ) ilave edildi. Bir aylık deneme süresi sonunda kan örnekleri alınarak serumda Na, K, Ca, Mg, P, Cl, Fe, Cu ve Zn düzeyleri ICP-Mass spektrometride ölçüldü. Rasyona 100 ve 200 ppm YS ekstraktı ilavesinin serum K, P ve Cl düzeylerini etkilemediği, buna karşın, Mg ve Zn düzeylerini artırdığı bulundu. Rasyona 200 ppm YS ekstraktı ilavesinin ise serum Na, Ca ve Fe düzeylerini artırırken, Cu düzeylerini ise azalttığı tespit edildi. Sonuç olarak, tavşanların yemine YS ekstraktı katılması, doza bağlı olarak bazı makro ve mikro elementlerin serum düzeylerinde değişikliğe yol açmıştır. Bu değişimlerin diğer hayvan türlerinde ve elementlerin biyoyararlanım düzeylerinde oluşturabileceği etkilerinin de belirlenebilmesi için daha fazla araştırma yapılması gereklidir.
