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  • Küçük Resim
    Öğe
    Intra-day changes in the levels of biochemistry parameters
    (2022) Arpacı, Abdullah; Doğan, Serdar; Gül, Bahar Ünlü; Kuş, Berna; Dırıcan, Emre
    Objectives: People mostly live in the nonfasting state during a normal 24-h cycle. This study aims to compare the levels of\r18 biochemical parameters during different hours of the day.\rMethods: A total of 18 biochemical tests of patients who visited outpatient clinics only once between January 1, 2010,\rand December 31, 2019, were evaluated at the Hatay Mustafa Kemal University (HMKU) Central Laboratory by using\rhospital database information. The tests are albumin (Alb), aspartate aminotransaminase (AST), alanine aminotransaminase\r(ALT), alkaline phosphatase (ALP), amylase, blood urea nitrogen (BUN), calcium (Ca), total cholesterol (TC), creatine\rkinase (CK), creatinine (Cr), gamma-glutamyltransferase (GGT), glucose, high-density lipoprotein cholesterol\r(HDL-C), inorganic phosphorus (Pi), iron (Fe), total protein (TP), triglyceride (TG), and lipase. The blood samples of the\rpatient were divided into eight groups according to their collection time as follows: (a) 07:00-07:59, (b) 08:00-08:59, (c)\r09:00-09:59, (d) 10:00-10:59, (e) 11:00-11:59, (f ) 12:00-13:59, (g) 14:00-14:59, and (h) 15:00-17:00.\rResults: A statistically significant difference was found between the groups in terms of all parameters except amylase,\rGGT, and TP (p<0.05). The effect size refers to the minimum amount of difference that is clinically significant. According\rto the effect size values, there was no significant difference between time groups in the following parameters: Alb, ALT,\rAST, Pi, Ca, TC, Cr, Fe, glucose, BUN, lipase, TG, ALP, HDL-C, and CK (?<0.30).\rConclusion: When considering all of the results, nonfasting screening would not only be acceptable but also make\rphysiologic sense.
  • Küçük Resim
    Öğe
    An investigation of olfactory bulb and entorhinal cortex volumesin both patients with Alzheimer’s disease and healthy individuals,and a comparative analysis of neuropeptides
    (2020) Petekkaya, Emine; Kaptan, Zülal; Ünalmış, Demet; Burakgazi, Gülen; Kuş, Berna; Melek, İsmet Murat; Arpacı, Abdullah
    Alzheimer’s Disease (AD) is the most common neurodegenerative disease and is hard to diagnose at the early stages. The pathogenesis of AD is associated with the loss of a sense of smell. Reduction in the volumes of the Olfactory Bulb (OB) and Entorhinal Cortex (EC) is positively correlated with the decline of the smelling function where OB projects to EC. This study aims to detect the early changes in OB and EC volumes in AD patients by comparing them to healthy subjects. This study also aims to make a comparative analysis of plasma levels and the relationship between arginine-vasopressin (AVP) and Oxytocin (OT), which are neuropeptides associated with cognitive functions. The participants comprised 9 AD patients and 12 healthy individuals. We used volumetric methods such as MRICloud and IBASPM to measure the OB and EC volumes with the help of 3D MRI (Magnetic Resonance Imaging) images. We compared the left and right differentiation. Moreover, we investigated the neuropeptide levels in blood samples from the participants. We conducted a correlation analysis for all parameters. Bilateral OB atrophy was discovered in the AD patients in comparison to the control group (p=0.002 for right; p=0.015 for left). The right OB volume was measured to be larger than the left OB volume in the control group,but this asymmetry was not observed in the AD patients. The right and left EC's of the AD patients were atrophic in comparison to the control (p<0.001). The atrophy of the left EC was measured to be higher than that of the right EC (p=0.0008). There was no significant difference between the OT and AVP plasma levels of the AD patients and the control group. The study revealed that the OB and EC volumes of the AD patients were bilaterally reduced in comparison to patients of similar ages. This outcome may indicate that an MRI scan examination of OB and EC volumes may help early AD diagnosis.
  • Küçük Resim
    Öğe
    Laboratuvarımıza yapılan başvurularda açlık - tokluk biyokimyasal parametrelerin değerlendirilmesi
    (Hatay Mustafa Kemal Üniversitesi, 2019) Kuş, Berna; Arpacı, Abdullah
    Geleneksel olarak hasta kanları sabah aç karnına laboratuvara teslim edilmektedir. Fakat son dönemlerde hastanelerin 24 saat hizmet vermesinden dolayı günün her saatinde hastalardan kan alınmakta ve açlıktan tam olarak emin olunamamaktadır. Çalışmamızda Hatay Mustafa Kemal Üniversitesi Sağlık Uygulama ve Araştırma Hastanesi Klinik Biyokimya Laboratuvarında 01.01.2019 ve 31.09.2019 tarihleri arasında (9 ay ) sadece bir kez polikliniğe başvuran hastaların hastane veri bankası bilgilerini kullanarak sağlıklı bireylerin klinikte en çok istenen 18 farklı kan biyokimya testlerinin (ALB, AST, ALT, ALP, AMİLAZ, BUN, CA, T-KOL, CK, CRE, GGT, GLU, HDL-K, iP, DEMİR, TP, TRIG, LIP) sonuçlarını istem saati baz alınarak açlık ve tokluk olmak üzere 2 gruba ayırıp her iki metabolik durum arasında anlamlı fark olup olmadığını literatürdeki araştırmalar ile karşılaştırmayı amaçladık. Çalışmamız retrospektif olup kullanılan test verileri A posteriori indirekt yöntem ile elde edilmiştir. Çalışma grupları, Hatay Mustafa Kemal Üniversitesi Sağlık Uygulama ve Araştırma Hastanesi Klinik Biyokimya Laboratuvarında 01.01.2019 ve 31.09.2019 tarihleri arasında (9 ay) sadece bir kez polikliniğe başvuran hastaların hastane veri bankası bilgileri kullanılarak oluşturulmuştur. Bu test sonuçları göz, kulak burun boğaz, ortopedi, nöroloji, hematoloji, dermatoloji, nöroloji ile fizik tedavi ve rehabilitasyon, genel cerrahi, endokrinoloji, dahiliye, nefroloji, gastroenteroloji polikliniklerinde ayakta tedavi gören hastalara ait sonuçlardır. Yatan hastaların verileri, onkoloji servisi ve polikliniği, acil servisi ve poliklinik, yoğun bakım, enfeksiyon hastalıkları ve 18 yaşından küçük hasta verileri değerlendirmeye alınmamıştır. Çalışmamızın sonucunda ALB, ALT, AST, BUN, CRE, CK, GGT, TP, GLU ve Ca değerlerinde p < 0,05 ile anlamlı fark gözlenmiştir. Fakat testler için effect size değerleri ölçüldüğünde klinik olarak anlamlı fark gözlenmemiştir. AMILAZ, iP, T-KOL, DEMİR, LIP, TRİG, HDL-K ve ALP değerlerinde p > 0,05 ile anlamlı fark gözlenmemiştir.