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Öğe Diabetes mellitus ve Lennox-gastaut sendrom'unun beraberliği: Bir olgu sunumu(2003) İncecik, Faruk; Leblebisatan, Göksel; Özcan, Kenan; Yüksel, BilginTip 1 Diabetes Mellitus (DM), çocukluk çağında en sık görülen otoimmün özellik gösteren endokrin metabolik bir hastalıktır. Lennox-Gastaut Sendromu (LGS) refrakter epilepsi, tipik EEG bulgusu ve mental retardasyonla seyreden çocukluk çağının epileptik sendromlarmdandır. Burada son 3-4 aydır sabah kasılmaları, gün içinde görülen aniden başın öne doğru düşmesi ve ani sıçramaları olan EEG'si LGS ile uyumlu bulunan 3 yıldır Tip 1 diabet melütus tanısı ile izlenen 6 yaşındaki erkek çocuğu takdim edildi. Tip 1 diabetin patogenezinde otoimmünitenin rol oynaması, patogenezi tam açıklığa kavuşmasa da hastamızda LGS'nun Tip 1 diabet mellitus ile beraber olması ve verilen IVIG tedavisi ile nöbetlerinde anlamlı derecede azalma olması bu iki hastalığın patogenezinde benzer otoimmün mekanizmaların rolü olabileceğini düşündürmektedir. Konu ile ilgili yapılacak geniş kapsamlı çalışmaların, LGS'nun patogenezinin anlaşılmasında katkıda bulunacağına inanılmaktadır.Öğe Insulin Like Growth Factor (IGF)(2004) Özcan, Kenan; Incecik, Faruk; Leblebisatan, GökselInsulin Like Growth Hormone (IGF) is a peptide family, depends on and suplying most of the anabolic and mitogenic effects of growth hormon (GH). Beside its GH dependance of serum consantration, showing its effects in tissues other than skeletal ones, increasing the binding of sulphate to the cartilage, stimulating the DNA synthesis and cell proliferation it has also some other duties. IGF-1 is a sample peptide of 70 aminoacids also celled SM-C. IGF-2 is an acidic peptide composed of 67 aminoacids. In both peptides 45 of the 73 aminoacid position are same and almost % 50 aminoacid of them also same with insulin. Both IGF consists of A and D chains binding with disulphide bindings like insulin. We present this review so as to evaluate the findings of the studies made in recent years about Insulin Like Growth Factor.Öğe Pseudotumor cerebri, after the withdrawal of steroid treatment(2005) Incecik, Faruk; Leblebisatan, Göksel; Özcan, Kenan; Erbey, FatihPseudotumor cerebri or benign idiopathic intracranial hypertension is a disease characterized by increased intracranial pressure without any lesion with mass effect or hydrocephaly. In etiology beside several factors, we want to present a case with pseudotumor cerebri after steroid withdrawal because its rarely seen.Öğe Startle disease-two sibling cases(2005) Elkay, Mürüvet; Incecik, Faruk; Hergüner, M. Özlem; Leblebisatan, Göksel; Altunbaşak, ŞakirStartle disease (hyperekplexia) is a rare non-epileptic disorder characterized by hypertonia, generalized stiffness and brief muscle jerks in response to unexpected auditory, somatosensory and visual stimuli. In this paper, two siblings with generalized stiffness and sudden muscle jerks to unexpected stimuli of various types are presented. They were previously misdiagnosed as epilepsy and treated with the conventional antiepileptic drugs. We wanted to call attention to and increase awareness of this rare disease and its differential diagnosis to avoid unnecessary investigations and treatment.Öğe Steroid tedavisinin kesimi sonrası gelişen psödotümör serebri(2005) İncecik, Faruk; Leblebisatan, Göksel; Özcan, Kenan; Erbey, FatihPseudotumor cerebri or benign idiopathic intracranial hypertension is a disease characterized by increased intracranial pressure without any lesion with mass effect or hydrocephaly. In etiology beside several factors, we want to present a case with pseudotumor cerebri after steroid withdrawal because its rarely seen.












