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1-15 Yaş arası çocuklarda demir eksikliği taramasında MCV ve RDW ölçümü
(2011) Arıca, Vefik; Arıca, Seçil; Tutanç, Murat; Edirne, Tamer; Gücük, Sabahat; Motor, Sedat
Amaç: Dünya Sağlık Örgütü’ne göre, demir eksikliği dünyadaki en sık rastlanan beslenme sorunudur. Demir eksikliği tüm vücut fonksiyonlarını etkileyen sistemik bir hastalıktır. Çalışmamızda demir eksikliği anemisi tanısını erken evrelerde koydurabilen ucuz, yaygın, kolay bir yöntem olan hemogram parametrelerinden eritrositlerin büyüklüklerine göre dağılım genişliği (Red Cell Distribution With-RDW) ve ortalama eritrosit hacmi (Mean Corpuscular Volume-MCV) değerlerinin özgüllüğü ve duyarlılığı üzerinde durulmuştur. Gereç ve Yöntem: Çalışmamızda hasta ve kontrol grubunu oluşturan olgular Çocuk Polikliniği'ne başvuran 1-15 yaş arasındaki 210 çocuktan oluşmaktadır. Geriye dönük dosyaları taranan hastaların; tam kan sayımı, serum demiri, total demir bağlama kapasitesi ve ferritinden değerleri ölçüldü. Demir eksikliği tanısı için ölçüt olarak; NHANES II'de (Second National Health and Nutrition Examination Survey) belirlenen, yaşa göre transferrin satürasyonu ve ferritin cut off değerleri kullanılmıştır. Bulgular: Hasta grubunun MCV ortalama değeri kontrol grubuna göre istatistiksel olarak ileri düzeyde anlamlı düşük bulunmuştur (p<0,001). Hasta grubunun RDW ortalama değeri kontrol grubuna göre istatistiksel olarak ileri düzeyde anlamlı yüksek bulunmuştur (p<0,001). Sonuç: Demir eksikliği erken tanısı için eritrosit indekslerinden RDW değerlerinin kullanılması, oldukça duyarlı ve özgül bir yöntemdir. MCV ve RDW’nin birlikte değerlendirilmesi, RDW’nin tek başına değerlendirilmesiyle eş bir duyarlılık değerine sahiptir.
Ameliorating effects of CAPE on oxidative damage caused by pneumoperitoneum in rat lung tissue
(E-Century Publishing Corp, 2014) Davarci, Isil; Alp, Harun; Ozgur, Tumay; Karcioglu, Murat; Tuzcu, Kasim; Evliyaoglu, Osman; Motor, Sedat
We investigated the biochemical and histopathological effects of caffeic acid phenethyl ester (CAPE) against oxidative stress causing lung injury induced by pneumoperitoneum. Twenty-eight rats were selected at random and seven rats were assigned to each of the following groups. The control group (S) was subjected to a sham operation without pneumoperitoneum. The other groups were subjected to CO2 pneumoperitoneum 15 mmHg for 60 min. The laparoscopy group (L) had no additional drugs administered, the laparoscopy + alcohol (LA) group had 1 ml of 70% ethyl alcohol administered 1 h before the desufflation period, and the laparoscopy + CAPE (LC) group had CAPE administered at 10 mu mol/kg 1 h before the desufflation period. The total oxidative status levels of lung and plasma were significantly increased in the LA group as compared with the LC and S group. When the LC group was compared with the L group, there was a decrease in the level of total oxidant status and increase in the levels of total antioxidant status and paraoxonase in lung tissue. The level of total antioxidative status in the S group was increased compared with the L group in lung tissue and bronchoalveolar lavage fluid. TNF-alpha and IL-6 were found significantly elevated in the L group compared with the LC and S groups in bronchoalveolar lavage fluid. There was a similar increase in plasma levels of IL-6. These results were supported by histopathological examination. CAPE was found to considerably reduce oxidative stress and inflammation induced by pneumoperitoneum.
The Analysis of Mean Platelet Volume and Platelet Distribution Width Levels in Appendicitis
(Springer India, 2015) Aydogan, Akin; Akkucuk, Seckin; Arica, Secil; Motor, Sedat; Karakus, Ali; Ozkan, Orhan Veli; Yetim, Ibrahim
We aimed to analyze the diagnostic value of mean platelet volume and platelet distribution width, which are also known as the markers of platelet count, in acute and perforated appendicitis. The data of 202 patients who applied to general surgery clinic in Mustafa Kemal University Hospital from 2007 to 2012 with acute appendicitis were analyzed retrospectively. The findings were separated to two groups due to the perforation status (perforated vs. non-perforated). Age, sex, leukocyte, hemoglobin, hematocrit, mean platelet volume, and platelet distribution width were examined. The mean age of the patients was 35.8. Twenty-one of all cases were perforated appendicitis (10.4 %), and the rest was acute appendicitis (non-perforated) (n=181, 89.6 %). The mean platelet volume value was 9.8 +/- 2.1 fL; mean thrombocyte count, 340.9x10(9)/L; and mean platelet distribution width value, 18.3 %. There were statistically significant differences between sex and age, hemoglobin, hematocrit, leukocyte, mean platelet volume, and platelet distribution width. There was a positive correlation between mean platelet volume, platelet distribution width, and platelet. Age, leukocyte, platelet, mean platelet volume, and platelet distribution width were higher in cases with perforation as a comparison with non-perforated cases. We think that mean platelet volume and platelet distribution width may be valuable markers to detect the risk of perforation in early periods of acute appendicitis.
Assessment of biochemical bone markers of osteoporosis in children with thalassemia major
(Bmc, 2022) Celik, Tanju; Sangun, Ozlem; Unal, Sule; Balci, Ali; Motor, Sedat
Background Beta thalassemia major (beta-TM) is a common cause of skeletal morbidity and is associated with increased bone fracture risk, particularly in inadequately transfused children. The aim of this study was to investigate some potential biochemical markers as possible early predictors of BMD variations in children with beta-TM. Methods The study included 38 children with beta-TM and 40 sex-age matched controls. All patients were subjected to BMD assessment by dual-energy X-ray absorptiometry (DEXA). Serum beta-crosslaps (beta-CTx), osteoprotegerin (OPG), receptor activator of nuclear factor-kappa B ligand (RANKL), urinary deoxypyridinoline (DPD) and ferritin levels were compared between the groups. Results Serum OPG levels were significantly lower in thalassemic children than in controls. The mean ratio of RANKL/OPG was significantly higher in the thalassemic patients than in the control group. Osteoporosis was detected in 10 (3 female and 7 male) of 38 patients (26.3%) according to the femur Z score and in 6 of them (4 male and 2 female) (15.8%) according to the spine Z score. Conclusions Serum OPG concentrations can be used as a biochemical marker in screening patients with beta-thalassemia major for the development of osteoporosis.
Assessment of the levels of nitric oxide (NO) in chronic diarrhea patients infected with Giardia intestinalis
(Academic Journals, 2012) Kaya, Ozlem M. Aycan; Atambay, Metin; Yula, Erkan; Ozyalin, Fatma; Motor, Vicdan Koksaldi; Motor, Sedat; Celik, Murat
Giardia intestinalis is an enteric pathogen causing certain digestive disorders by attaching itself on the human intestine and, especially on the duodenum. It is reported that there is a strong relationship between the nitric oxide (NO) level and the clinical prognosis of the infection in infections of G. intestinalis. The aim of the study was to investigate serum NO levels in samples taken from patients with G. intestinalis detected in the microscopic stool examination and from the control group consisting of healthy people and the presence of any relationship with Giardiosis. The study consisted of 60 patients diagnosed with G. intestinalis in microscopic stool examination, [31 (51.7%) male, 29 (48.3%) female] and 60 healthy people [28 (46.7% male, 32 (53.5%) female] as the control group. All patients in the patient group with gastrointestinal symptoms had chronic diarrhea and cysts and trophozoites were observed in microscopic examination of the feces in all of them. Measurement of serum NO level was performed using Cortas method. When the data were evaluated by T-test in the Independent Groups, NO levels in the patient group was found low at a statistically significant level. In Giardiosis, the decline in the NO level suggested that the disease causes a more severe clinical presentation. In addition to this, we consider it necessary that extensive experimental or clinical studies be conducted on the subject.
Carcass and Meat Quality Characteristics of White and Multicolor Geese under Local Breeder Conditions
(Kafkas Univ, Veteriner Fakultesi Dergisi, 2012) Yakan, Akin; Elmali, Dilek Aksu; Elmali, Mehmet; Sahin, Tarkan; Motor, Sedat; Can, Yesim
The purpose of this study was to define the meat quality characteristics of White and Multicolor geese under local breeder conditions. While carcass and edible offal percentages were similar breast, back and wing ratios were statistically different between White and Multicolor geese. Phenotypic color differentiation between geese varieties was reflected on both breast meat and skin (except a* value). While White geese had better values than Multicolor geese for saturated fatty acid and monounsaturated fatty acid, Multicolor geese were higher than White geese for polyunsaturated fatty acid. Nutritive value of White variety was higher than Multicolor variety in breast meat, skin and abdominal fat.
Comparison of the chronic effects of ribavirin and caffeic acid phenethyl ester (CAPE) on pancreatic damage and hepatotoxicity
(E-Century Publishing Corp, 2014) Motor, Sedat; Alp, Harun; Senol, Serkan; Pinar, Neslihan; Motor, Vicdan Koksaldi; Kaplan, Ibrahim; Alp, Ayse
This study was aimed to comparison of the effects of the chronic use of the Ribavirin and caffeic acid phenethyl ester (CAPE) on the pancreatic damage and hepatotoxicity in rats. Methods: The rats were given orally 30 mg/kg/day doses of Ribavirin for 30 days, and intraperitoneally 10 mu mol/kg doses of CAPE. The 37 rats were divided into 4 groups: (I) Control (n=7), (II) Ribavirin (R) (n=10), (III) CAPE (n=10), and (IV) R+CAPE (n=10). Results: Ribavirin and CAPE yielded similar results in terms of Serum, total antioxidant status (TAS), total oxidant status (TOS), amylase, lipase, and insulin compared to the control group. However, while Ribavirin provided similar results with the control group in terms of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) enzymes, the CAPE group had elevated AST and ALT levels compared to the control group. Histopathologic evaluations revealed that CAPE or Ribavirin had no degenerative effects on both the pancreas and liver tissues. In this way, the biochemical results were confirmed by the histopathologic results. Conclusion: It can be concluded that Ribavirin does not lead to any pancreatic damage and hepatotoxicity, and has more beneficial effects than CAPE on especially liver tissue.
Convulsion in infants as a result of oral use of garden sage
(Galenos Yayincilik, 2012) Arica, Vefik; Arica, Secil; Tutanc, Murat; Motor, Sedat; Motor, Vicdan Koksaldi; Dogan, Murat
Salvia officinalis is a plant known as Garden Sage and it is used by the community in case of various clinical conditions. Herbalists are the right destinations to provide this special plant. Salvia officinalis is known to be used for its diuretic, anti-inflammatory, antimicrobial, antiseptic, expectorant, spasmolytic and diaphoretic effects. In this case study, a case of intoxication in which a 2-month old infant who presented with convulsion due to accidental oral use of garden sage oil which was actually prepared for topical use by a herbalist is reported. (Turk Arch Ped 2012; 47:67-8)
Daily and every other day use of iron prophylaxis in the first year of life
(Galenos Yayincilik, 2010) Arica, Vefik; Arica, Secil; Tutanc, Murat; Motor, Sedat; Onur, Hatice; Dogan, Murat
Aim: In countries like Turkey where iron deficiency anemia (IDA) is common, it was that iron prophylaxis can be used every other day as intermittent because it would show the same effect and easier for compliance. Material and Method: Two groups of infants born healthy, breastfed exclusively for the first six months and given 400 IU vitamin D were included in the study. In the fourth month of their life, infants started to take iron (Fe +2) 1 mg/kg/day and the second group 2 mg/kg/48 h In use of daily 1 mg/kg/day dose as of the fourth month till the first year 75 patients (the first group), in use of 2 mg/kg/48 h 80 patients (the second group) were involved in our study group. 34 infants (the third group) who did not start to take iron prophylaxis or use any was taken in our study as a control group. Results: It was found out that in the first group 14 infants (18.6%) developed iron deficiency (ID), 3 infants (4%) iron deficiency anemia (IDA), in the second group 16 infants (20%) developed ID and 4 infants (5%) IDA, in the third group, namely in the control group 12 infants (35,3%) developed ID and 10 infants (29.4%) IDA. In comparison of the control group with the first and second groups, IDA portion was less in iron prophylaxis groups, this value was found statistically reliable (p=0.001). When the first and second groups were compared with one another, a statistical difference could not be found between ID/IDA proportions. Because ID and IDA were encountered in both prophylaxis groups it was assumed that iron prophylaxis given just during the first year of life should also be given afterwards. Conclusions: There is no statistical difference between the first and second prophylaxis groups, thus, it was considered that instead of daily use, taking iron every other day would be more effective when it was given in a proper dose. (Turk Arch Ped 2010; 45: 343-7)
Delays in reporting critical values from clinical laboratories to responsible healthcare staff
(Walter De Gruyter Gmbh, 2017) Ozcan, Oguzhan; Cakirca, Gokhan; Motor, Sedat; Yonden, Zafer
Objective: We aimed to investigate the frequency of delayed notifications and probable causes of delays for critical value notification in clinical laboratory of university hospital. Materials and methods: All data was obtained from critical value reporting forms and laboratory information system. The frequency and location of critical and delayed results, latencies throughout a working day and the professional status who received the critical callbacks were shown as percentages. Results: A total of 2018 (1.02%) critical values were reported and 13.1% of them were delayed notifications. Most of them were observed in laboratory tests ordered from patients of service and polyclinics compared to ICU and emergency department (26.7%, 26%, 6.2% and 4.9%, respectively, p < 0.01). Delayed notifications were significantly higher for biochemical parameters (19.7%, p < 0.001) and observed particularly in morning hours (06: 00 a. m.-10: 00 a. m.), lunch break time (12: 00-14: 00) and end of the working day (16: 00-18: 00). Latencies of mild-delayed reporting were 18.5 +/- 4.4 min for 62.8% and advanced-delayed reporting were 47.1 +/- 11.3 min for 37.2% of total delayed notifications. Most of the critical results were reported to the health care staff other than physician (55.6%). Conclusion: Laboratory professionals should work in collaboration with responsible clinician and healthcare staff in critical value reporting process.
Deneysel kolit modelinde centella asiatika ekstresinin etkinliği
(2017) Özgür, Tümay; Özcan, Oğuzhan; Akküçük, Seçkin; Kılıç, Erol; Koyuncu, Onur; Oruç, Cem; Aydoğan, Akın; Öztürk, Ozan Utku; Motor, Sedat; Yetim, İbrahim; Temiz, Muhittin
Amaç: İnflamatuvar barsak hastalıkları (İBH) çevresel, genetik ve immün faktörlerin sebep olduğu düşünülen bir grup kronik ve inflamatuvar durum olarak tanımlanmaktadır. Tedavisinde başlıca antiinflamatuvar, immünsupresif ve sitotoksik ilaç kombinasyonları kullanılmaktadır. Fakat bu ajanların ciddi yan etkilerinden dolayı yeni tedavi yöntemleri bulmak için araştırmalar yapılmaktadır. Bu çalışmanın amacı dekstran sülfat sodium (DSS) ile indüklenmiş deneysel kolit modelinde Centella Asiatica (CA) ekstresinin etkinliğini araştırmaktır. Gereç ve Yöntem: Çalışmada 24 adet Wistar Albino rat üç eşit gruba ayrıldı. Grup 1' e (kontrol) sadece su verildi. Grup 2' ye (kolit) DSS' li içme suyu ve Grup 3'e (medikasyon grubu) 200mg/kg/gün CA ekstresi ve DSS' li içme suyu verildi. Deney sonunda kolonun histopatolojik incelemesi ve myeloperoksidaz (MPO), malonildialdehit (MDO), tümör nekroz factör alfa (TNF-?) ve interlökin-10 (IL-10) düzeyleri belirlendi. Bulgular: CA ekstratı veilen grupta kolit grubu ile kıyaslandığında TNF- ? düzeyi daha düşüktü ve İL 10 düzeyi daha yüksekti. MPO ve MDA düzeyleri kolit grubunda diğer gruplarla karşılaştırıldığında anlamlı düzeyde daha yüksek bulundu. (p<0.05). Histopatolojik incelemede medikasyon grubunda daha az doku hasarı saptandı. Sonuç: CA ekstresi proinflamatuvar ve antiinflamatuvar sitokin düzeyini değiştirerek immünregulatuvar bir etki göstermektedir. Ayrıca serbest oksijen radikalleri oluşumunu önleyerek doku hasarını önlemektedir. Bu etkilerinden dolayı CA ekstresinin İBH tedavisinde faydalı bir ajan olarak kullanılabileceğini düşünmekteyiz.
Diabetes mellituslu hemodiyaliz hastalarında HbA1c ile kan glukozu düzeyleri arasındaki ilişki
(2013) Motor, Sedat; Dokuyucu, Recep; Sefil, Fatih; Rifaioğlu, Mehmet Murat; Erhan Yengil; Kemal Türker Ulutaş; Ahmet Taner Sümbül; Rızaoğlu, Hatice; Üstün, İhsan; Gökçe, Cumali
Amaç: Bu çalışmada Diabetes mellitus (DM)’lu, kronik böbrek yetmezliği olan ve diyalize giren hastalarda HbA1c düzeyleri ile kan glukozu düzeyleri arasındaki ilişkinin incelenmesi amaçlanmıştır. Yöntemler: 1 Ocak 2009-31 Temmuz 2010 tarihleri arasında, özel bir diyaliz merkezinde diyalize giren 131 (53 kadın, 78 erkek) hastanın aylık kan glukozu ve 3 aylık HbA1c sonuçları geriye dönük olarak incelendi. Bulgular: 131 olgunun yaş ortalaması 63,3±11,2 yıl (30- 91 yaş arası) idi. Bu olguların 53’ü kadın (%40,5), 78’i erkek (%59.5) idi. Kadınların yaş ortalaması 62,2±11,2 iken erkeklerin yaş ortalaması 64,1±11,2 idi. Kadınların ve erkeklerin ortalama glukoz değeri ile ortalama HbA1c de- ğeri arasında korelasyon vardı (Kadın: p<0,001, r=0.761, Erkek: p<0.001, r=0.743). Tüm gruplar arası ortalama glukoz değeri ile ortalama HbA1c arasında korelasyon vardı (p<0.001, r=755). İncelenen HbA1c sonuçlarının %32.8’ i %6.5 değerinin altında tespit edilirken, % 67,2’ si %6.5 değerinin üzerinde tespit edildi. Açlık kan glukozu değerlerinin %18,3’ ü 126 mg/dl değerinin altında tespit edilirken, %81,3’ ü 126 mg/dl değerinin üzerinde tespit edilmiştir. Ortalama kan glukozu değeri ile HbA1c değerleri arasında korelasyon bulundu. Sonuç: Açlık, tokluk kan glukozu ve HbA1c ölçümleri kötü glisemik kontrolün tanı, izlem ve tedavisinde önemlidir. Dolayısıyla diyabetik nefropatili diyaliz hastalarında, HbA1c ve kan glukozu (açlık ve tokluk) ölçümü ve bunlar arasındaki korelasyon, kardiyovasküler mortalite ve morbidite açısından ve DM’nin izlemi açısından son derece önemlidir.
The effect of caffeic acid phenethyl ester on isoproterenol-induced myocardial injury in hypertensive rats
(2014) İlhan, Selçuk; Yılmaz, Nigar; Nacar, Emel; Motor, Sedat; Oktar, Süleyman; Şahna, Engin
Objective: The aim of this study is to investigate the effects of caffeic acid phenethyl ester (CAPE) on isoproterenol (ISO)-induced myocardial injury in hypertensive rats. Methods: Rats were divided into 4 groups (n=29): Control group (n=8), L-NNA (NG-Nitro-L-arginine) group (n=8), L-NNA+ISO (L-NNA+isoproterenol) group (n=7) and L-NNA+ISO+CAPE (L-NNA+ISO + caffeic acid phenethyl ester) group (n=6). ISO (150 mg/kg/day) was given intraperitoneally (i.p.) once a day for 2 consecutive days (at the 12th and 13th days of L-NNA treatment). NG-Nitro-L-arginine (L-NNA) was given orally (25 mg/kg/day) in drinking water for 14 days. CAPE (10 ?mol/kg/day) was given (i.p.) for 7 days after the first week. Systolic blood pressure (SBP) was evaluated by the tail-cuff method and biochemical analysis were performed using an autoanalyzer and a spectrophotometer.Results: SBP in all L-NNA-treated groups was found to be increased at seventh day. AST and LDH levels in LNNA+ISO group were significantly increased compared to control (AST: 125±5 vs. 105±2; LDH: 861±154 vs. 571±46 U/L respectively) (p<0.05). Also, ISO caused to extensive necrosis and mononuclear cell infiltration in hypertensive rat myocardium. CAPE application reversed the enhanced AST and LDH levels as well as the extensive necrosis and the mononuclear cell infiltration in LNNA+ISO+CAPE group compared LNNA+ISO.Conclusion: According to our findings, it might be suggested that CAPE may be a favorable agent to protect the hypertensive myocardium from the injury induced by isoproterenol via mechanisms such as the induction of the antioxidant enzymes and the inhibition of lipid peroxidation.
THE EFFECTS OF ERDOSTEINE ON COAGULATION IN RATS
(Carbone Editore, 2014) Motor, Sedat; Alp, Harun; Yuksel, Rana; Erden, Ersin Sukru; Oktar, Suleyman; Celik, Salih; Cayirci, Gokhan
Background and objectives: Erdosteine, a thiol derivative in the same group as N-acetyl cysteine, belongs to a class of medicines called expectorants. Aim: It was aimed to determine effects of erdosteine (ERD) on coagulation. Material and methods: A total of 23 female rats were divided into three groups as control (C) (n=7), ERD-10 (n=7), ERD-50 (n=9). Rats in C group were given dilution of 0.3 ml sodium bicarbonate [NaHCO3]; rats in ERD-10 group were given 10 mg/kg ERD; and rats in ERD-50 group were given 50 mg/kg ERD. The drugs were given for ten days by oral gavage. Blood samples were drawn from the heart 24 hours after the last drug dose, and coagulation parameters were measured with automated analyzers. Results: While Factor VIII and AT-III levels decreased in both ERD-10 and ERD-50 group, Factor IX levels only decreased in ERD-50 group. Also, INR, PT and aPTT were prolonged in the ERD-50 group compared with the control and ERD-10 groups. There was no significant difference between groups for protein C and S. Conclusion: The results showed that erdosteine may increase bleeding tendencies in a dose-related manner. Therefore, we suggest that it should be noted when erdosteine is used together with anticoagulant medications. In addition, patients should be questioned regarding the use of erdosteine before dental or medical operations in order to prevent bleeding abnormalities.
The effects of erdosteine on coagulation in rats
(Acta Medica Mediterranea, 2014) Motor, Sedat; Alp, Harun; Yuksel, Rana; Erden, Ersin Sukru; Oktar, Suleyman; Celik, Salih; Cayirci, Gokhan
Background and objectives: Erdosteine, a thiol derivative in the same group as N-acetyl cysteine, belongs to a class of medicines called expectorants. Aim: It was aimed to determine effects of erdosteine (ERD) on coagulation. Material and methods: A total of 23 female rats were divided into three groups as control (C) (n=7), ERD-10 (n=7), ERD-50 (n=9). Rats in C group were given dilution of 0.3 ml sodium bicarbonate [NaHCO3]; rats in ERD-10 group were given 10 mg/kg ERD; and rats in ERD-50 group were given 50 mg/kg ERD. The drugs were given for ten days by oral gavage. Blood samples were drawn from the heart 24 hours after the last drug dose, and coagulation parameters were measured with automated analyzers. Results: While Factor VIII and AT-III levels decreased in both ERD-10 and ERD-50 group, Factor IX levels only decreased in ERD-50 group. Also, INR, PT and aPTT were prolonged in the ERD-50 group compared with the control and ERD-10 groups. There was no significant difference between groups for protein C and S. Conclusion: The results showed that erdosteine may increase bleeding tendencies in a dose-related manner. Therefore, we suggest that it should be noted when erdosteine is used together with anticoagulant medications. In addition, patients should be questioned regarding the use of erdosteine before dental or medical operations in order to prevent bleeding abnormalities.
Effects of Paliperidone Palmitate on Coagulation: An Experimental Study
(Hindawi Ltd, 2014) Yilmaz, Enver Demirel; Motor, Sedat; Sefil, Fatih; Pinar, Neslihan; Kokacya, Hanifi; Kisa, Mustafa; Oktar, Suleyman
Objective. The aim of the present study was to examine the effects of a new antipsychotic drug paliperidone palmitate on hemogram and coagulation parameters in rats. Materials and Methods. Experiments were performed on 22 female albino Wistar rats (8-12 weeks old). Control group was given drinking water as vehicle (0.3 mL). PAL-1 rats were given 1 mg/kg paliperidone palmitate (in 0.3 mL drinking water) by oral gavage once a day for ten days and PAL-3 rats received 3 mg/kg paliperidone palmitate (in 0.3 mL drinking water) by oral gavage for ten days. Blood samples were drawn from the heart 24 hours after the last drug dose, and hemogram and coagulation parameters were measured with automated analyzers. Results. Hemogram did not change in the paliperidone treated groups compared to the controls. Factor VIII levels decreased in the PAL-1 and PAL-3 groups; and this decrease was significantly greater in the PAL-3. Factor IX levels decreased in PAL-3 rats, but its levels also increased in PAL-1 rats compared to the control. Discussion. Paliperidone has led to changes in the serum levels of coagulation factors VIII and IX in rats. As a result, paliperidone may be causing thromboembolism or bleeding in a dose-independent manner.
Evaluation of total antioxidant status, total oxidant status and oxidative stress index in patients with alopecia areata
(E-Century Publishing Corp, 2014) Motor, Sedat; Ozturk, Sahin; Ozcan, Oguzhan; Gurpinar, Ahmet Burak; Can, Yesim; Yuksel, Rana; Yenin, Julide Zehra
Objectives: In this study, we aimed to evaluate total oxidative stress and total antioxidant capacity in serum samples from patients with Alopesia Areata (AA) in our laboratory conditions. Methods: In this study, 46 subjects with AA (26 females, 20 males) and the control subjects of 36 (20 females, 16 males) age-and sex-matched healthy volunteers from our hospital staffs were enrolled (the mean age was 23.7 +/- 11.0 years). Blood samples were obtained following an overnight fasting state, and were collected on ice at 4 degrees C. The serum samples were separated from the cells by centrifugation at 3000 rpm for 15 min and were stored at -80 degrees C and used for the analysis of the Total Antioxidant Status (TAS) and Total Oxidant Status (TOS). Results: Total Antioxidant Status (TAS) and Total Oxidant Status (TOS), Oxidative Stress Index (OSI) (TOS/TAS) levels of AA patients were 1.4777 +/- 0.1986; 9.7490 +/- 6.0445; 0.6593 +/- 0.4069 respectively. TAS; TOS; OSI (TOS/TAS) levels of controls were 1.4028 +/- 0.1687; 9.4627 +/- 4.2781; 0.6875 +/- 0.3232 respectively. TAS, TOS and OSI levels showed no significant difference between the control and AA group (p > 0.05). Conclusion: Future studies about AA pathogenesis should be based not only on oxidant/antioxidant balance but also on several other factors. Because it was observed that the disease showed recurrence in different situations. Since the selection criteria of patients is affected from disease severity and environmental and genetical factors, multicentric studies with better sampled patient population and higher patient number is required.
Halk elinde yetiştirilen beyaz ve alaca kazlarda karkas ve et kalitesi özellikleri
(2012) Yakan, Akın; Aksu Elmalı, Dilek; Elmalı, Mehmet; Şahin, Tarkan; Motor, Sedat; Can, Yeşim
Bu çalışma halk elinde yetiştirilen Beyaz ve Alaca kazlarda karkas ve et kalitesi özelliklerinin tespit edilmesi amacıyla yapılmıştır. Beyaz ve Alaca kazlarda karkas randımanları ve iç organların oranları bakımından farklılıklar önemli olmazken, karkas parçalarından göğüs, sırt ve kanat oranları bakımından önemli farklılıklar bulunmuştur. Varyeteler arasındaki fenotipte görülen renk farklılığının hem göğüs etine hem de deriye (kırmızılık indeksi hariç) yansıdığı tespit edilmiştir. Göğüs etinde doymuş yağ asidi ve tekli doymamış yağ asidi değerleri Beyaz kazlarda daha iyi iken aşırı doymamış yağ asidi değerleri Alaca kazlarda daha iyi olarak belirlenmiştir. Göğüs eti, deri ve abdominal yağda Besleyici Değer İndeksi’nin Beyaz kazlarda Alaca kazlara göre daha yüksek olduğu saptanmıştır.
Holştayn ırkı üç inekte sekum dilatasyonu, dislokasyonu ve torsiyonu
(2012) İşler, Cafer Tayer; Altuğ, Muhammed Enes; Altuğ, Nuri; Motor, Sedat
In this study, cecal dilatation-dislocation and torsion diagnosed using laparotomy technic in three Holstein cows with the ages of 5 (first case), 7 (second case), and 8 (third case) years, respectively, were evaluated. The animals were brought to the clinics of the Faculty of Veterinary Medicine, Mustafa Kemal University, one month later after parturition, with the complaints of anorexia, restlessness, weight loss, and decreased milk production. In clinical examination; dehydration at varying levels was observed in all cases. Simultaneous auscultation and percussion revealed ping sounds in right abdomen. The levels of serum Na +, K+, Cl-, Ca+2 and P -3 were determined to decrease, while creatinine levels increased. Experimental laparotomy through the right paralumbar fossa disclosed necrosis in the mesentery of the region of the ileo-seco-colic torsion. Thus, perforation was seen in the first and second cases. As treatment; cecal content was evacuated, the torsions were corrected, and th e perforated necrotic areas were resected and sutured. The second and the third cases recovered but the animal in the first case was sent to slaughter due to deterioration during the post-operative period. As a result, the priority of medical or surgical treatment should be based on the changes in clinical and laboratory findings in the cases of cecal dilatation, dislocation and torsion. Additi onally, it is concluded that reduced iron level may be considered as a prognostic indica tor observed in the cases with dehydration, gastrointestinal bleeding, and anemia.
The Injection of Air/Oxygen Bubble into the Anterior Chamber of Rabbits as a Treatment for Hyphema in Patients with Sickle Cell Disease
(Hindawi Ltd, 2014) Ayintap, Emre; Keskin, Ugurcan; Sadigov, Fariz; Coskun, Mesut; Ilhan, Nilufer; Motor, Sedat; Semiz, Hilal
Purpose. To investigate the changes of partial oxygen pressure (PaO2) in aqueous humour after injecting air or oxygen bubble into the anterior chamber in sickle cell hyphema. Methods. Blood samples were taken from the same patient with sickle cell disease. Thirty-two rabbits were divided into 4 groups. In group 1 (n = 8), there was no injection. Only blood injection constituted group 2 (n = 8), both blood and air bubble injection constituted group 3 (n = 8), and both blood and oxygen bubble injection constituted group 4 (n = 8). Results. The PaO2 in the aqueous humour after 10 hours from the injections was 78.45 +/- 9.9 mmHg (Mean +/- SD) for group 1, 73.97 +/- 8.86 mmHg for group 2, 123.35 +/- 13.6 mmHg for group 3, and 306.47 +/- 16.5 mmHg for group 4. Therewas statistically significant difference between group 1 and group 2, when compared with group 3 and group 4. Conclusions. PaO2 in aqueous humour was increased after injecting air or oxygen bubble into the anterior chamber. We offer to leave an air bubble in the anterior chamber of patients with sickle cell hemoglobinopathies and hyphema undergoing an anterior chamber washout.

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