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Öğe Assessment of the levels of nitric oxide (NO) in chronic diarrhea patients infected with Giardia intestinalis(Academic Journals, 2012) Kaya, Ozlem M. Aycan; Atambay, Metin; Yula, Erkan; Ozyalin, Fatma; Motor, Vicdan Koksaldi; Motor, Sedat; Celik, MuratGiardia intestinalis is an enteric pathogen causing certain digestive disorders by attaching itself on the human intestine and, especially on the duodenum. It is reported that there is a strong relationship between the nitric oxide (NO) level and the clinical prognosis of the infection in infections of G. intestinalis. The aim of the study was to investigate serum NO levels in samples taken from patients with G. intestinalis detected in the microscopic stool examination and from the control group consisting of healthy people and the presence of any relationship with Giardiosis. The study consisted of 60 patients diagnosed with G. intestinalis in microscopic stool examination, [31 (51.7%) male, 29 (48.3%) female] and 60 healthy people [28 (46.7% male, 32 (53.5%) female] as the control group. All patients in the patient group with gastrointestinal symptoms had chronic diarrhea and cysts and trophozoites were observed in microscopic examination of the feces in all of them. Measurement of serum NO level was performed using Cortas method. When the data were evaluated by T-test in the Independent Groups, NO levels in the patient group was found low at a statistically significant level. In Giardiosis, the decline in the NO level suggested that the disease causes a more severe clinical presentation. In addition to this, we consider it necessary that extensive experimental or clinical studies be conducted on the subject.Öğe BRUCELLAR SPONDYLODISCITIS IN THE CERVICAL REGION(Professional Medical Publications, 2010) Evirgen, Omer; Altas, Murat; Davran, Ramazan; Motor, Vicdan Koksaldi; Onlen, YusufDiagnosis of brucella infection may be difficult, because it can mimic many other diseases. We report a 57-year old man who had presented with the complaints of radiculopathy, and was diagnosed as cervical spondylodiscitis. The spondylodiscitis was diagnosed via rose bengal test, positive serology, and positive culture results after the initial suspicion with magnetic resonance imaging. Streptomycin for 14 days and doxycycline rifampicin for tree months were used for the treatment. Brucellar spondylodiscitis in the cervical region is a rare presentation, beside that prognosis with early diagnosis and adequate treatment is good.Öğe Brucellar spondylodiscitis in the cervical region(2010) Evirgen, Omer; Altas, Murat; Davran, Ramazan; Motor, Vicdan Koksaldi; Onlen, YusufDiagnosis of brucella infection may be difficult, because it can mimic many other diseases. We report a 57-year old man who had presented with the complaints of radiculopathy, and was diagnosed as cervical spondylodiscitis. The spondylodiscitis was diagnosed via rose bengal test, positive serology, and positive culture results after the initial suspicion with magnetic resonance imaging. Streptomycin for 14 days and doxycycline rifampicin for tree months were used for the treatment. Brucellar spondylodiscitis in the cervical region is a rare presentation, beside that prognosis with early diagnosis and adequate treatment is good.Öğe Comparison of the chronic effects of ribavirin and caffeic acid phenethyl ester (CAPE) on pancreatic damage and hepatotoxicity(E-Century Publishing Corp, 2014) Motor, Sedat; Alp, Harun; Senol, Serkan; Pinar, Neslihan; Motor, Vicdan Koksaldi; Kaplan, Ibrahim; Alp, AyseThis study was aimed to comparison of the effects of the chronic use of the Ribavirin and caffeic acid phenethyl ester (CAPE) on the pancreatic damage and hepatotoxicity in rats. Methods: The rats were given orally 30 mg/kg/day doses of Ribavirin for 30 days, and intraperitoneally 10 mu mol/kg doses of CAPE. The 37 rats were divided into 4 groups: (I) Control (n=7), (II) Ribavirin (R) (n=10), (III) CAPE (n=10), and (IV) R+CAPE (n=10). Results: Ribavirin and CAPE yielded similar results in terms of Serum, total antioxidant status (TAS), total oxidant status (TOS), amylase, lipase, and insulin compared to the control group. However, while Ribavirin provided similar results with the control group in terms of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) enzymes, the CAPE group had elevated AST and ALT levels compared to the control group. Histopathologic evaluations revealed that CAPE or Ribavirin had no degenerative effects on both the pancreas and liver tissues. In this way, the biochemical results were confirmed by the histopathologic results. Conclusion: It can be concluded that Ribavirin does not lead to any pancreatic damage and hepatotoxicity, and has more beneficial effects than CAPE on especially liver tissue.Öğe Convulsion in infants as a result of oral use of garden sage(Galenos Yayincilik, 2012) Arica, Vefik; Arica, Secil; Tutanc, Murat; Motor, Sedat; Motor, Vicdan Koksaldi; Dogan, MuratSalvia officinalis is a plant known as Garden Sage and it is used by the community in case of various clinical conditions. Herbalists are the right destinations to provide this special plant. Salvia officinalis is known to be used for its diuretic, anti-inflammatory, antimicrobial, antiseptic, expectorant, spasmolytic and diaphoretic effects. In this case study, a case of intoxication in which a 2-month old infant who presented with convulsion due to accidental oral use of garden sage oil which was actually prepared for topical use by a herbalist is reported. (Turk Arch Ped 2012; 47:67-8)Öğe Effect of Thymoquinone on Oxidative Stress in Escherichia coli-Induced Pyelonephritis in Rats(Elsevier Science Inc, 2011) Evirgen, Omer; Gokce, Ahmet; Ozturk, Oktay Hasan; Nacar, Emel; Onlen, Yusuf; Ozer, Burcin; Motor, Vicdan KoksaldiBACKGROUND: Recurrent urinary tract infections are important in children and adults with diabetes mellitus and/or incontinence due to risk of pyelonephritis (PYN) and renal damage. There is a positive correlation released free radicals during PYN and renal damage. Experimental studies showed that antioxidant agents improve renal damage when used immediately after bacterial inoculation. OBJECTIVE: The aim of the present study was to evaluate whether treatment by thymoquinone (TQ) before or during Escherichia coli inoculation prevents oxidative damage in acute pyelonephritis (PYN) in an ascending obstructive rat model. METHODS: In this study, 42 Wistar rats were grouped as follows: control, PYN (24, 48, and 72 hours), and TQ-PYN (24, 48, and 72 hours). E. coli (1 x 10(9) colony forming units) was inoculated into the bladder via urethral catheterization in both the PYN and TQ groups. TQ injections were performed 24 hours before bacteria inoculation and repeated at 24-hour intervals during the indicated time at a dose of 10 mg/kg body weight intraperitoneally in TQ groups. RESULTS: Superoxide dismutase activity was statistically lower in the TQ-PYN-48 and -72 groups than the PYN-48 and -72 groups (P < 0.001, P = 0.004, respectively). Catalase activity was significantly higher in PYN-24, -48, and -72 groups than the control group (P < 0.001). In addition, there was a significant difference between the TQ-PYN-24, -48, and -72 groups and PYN groups in terms of glutathione peroxidase activity (P < 0.001, P = 0.026, P = 0.046, respectively). When the TQ-PYN-72 group was compared with the PYN-72 group, malondialdehyde levels were significantly lower in the TQ-PYN-72 group than in the PYN-72 group (P = 0.033). A histologic examination also confirmed the protective effect of TQ. In statistical analysis of histopathologic findings, there were significant differences between the PYN-24 and TQ-PYN-24, PYN-48 and TQ-PYN-48, and PYN-72 and TQ-PYN-72 groups (P = 0.008, P < 0.001, P < 0.001, respectively). CONCLUSIONS: The results indicate that TQ administration attenuated the oxidative damage that occurred in PYN and, therefore, could be used as a supportive agent to protect the kidneys from oxidative damage caused by PYN. (Curr Ther Res Clin Exp. 2011;72:204-215) (C) 2011 Elsevier HS Journals, Inc. All rights reserved.Öğe The Evaluation of HBV-DNA Levels In Patients who Had Lost Hbsag After Recovery From Hepatitis B Virus Infection(Galenos Yayincilik, 2012) Motor, Vicdan Koksaldi; Celikbas, Aysel Kocagsul; Baykam, Nurcan; Gok, Sebnem Eren; Dokuzoguz, BasakObjective: The risk of transmitting hepatitis B virus has been reported to continue in the blood of people with loss of HBsAg after recovery from hepatitis B virus infection. The aim of the present study was to investigate the hepatitis B virus DNA in patients with loss HBsAg after recovery from hepatitis B virus infection by using polymerase chain reaction. Materials and Methods: Total 57 cases were evaluated. Hepatitis B virus DNA was detected in 19 (43.2%) of 44 patients with loss of HBsAg after acute hepatitis B virus infection, and in 2 (15.4%) of 13 cases who had natural immunity with positive antiHBs. Results: Infectivity continued in 21 (36.8%) cases. Hepatitis B virus DNA levels were detected between 4.6 x102 with 1x105 genome / mL in these serum samples. Conclusion: In our study, hepatitis B virus DNA can positive in patients with loss of HBsAg after hepatitis B virus infection have been shown. For this reason, antiHBc screening more reliable than HBsAg was thought in the selection of blood donors. It was thought that hepatitis B virus DNA testing with polymerase chain reaction is appropriate in serum and tissues of donors with positive hepatitis B virus serology in the organ transplantation practices.Öğe An evaluation of knowledge, attitudes, and behaviors of employees of a university hospital in an H1N1 influenza pandemic(J Infection Developing Countries, 2014) Evirgen, Omer; Savas, Nazan; Motor, Vicdan Koksaldi; Onlen, Yusuf; Yengil, ErhanIntroduction: In this study, we aimed to evaluate the knowledge, attitudes, and behaviors concerning the transmission routes of an H1N1 pandemic and the protective measures of health professionals at a university hospital in Turkey. Methodology: A stratified systematic sampling method was used to select the sample size of the study group. A total of 22 professors, 29 researchers, and 26 nurses were included in the study. Results: The mean scores of the individuals were 8.4 +/- 2.5 (over 20) for knowledge about H1N1 transmission, 27.6 +/- 4.0 (over 60) for knowledge about protection against H1N1, 25.8 +/- 4.2 (over 45) for correct or appropriate attitudes, and 33.6 +/- 8.9 (over 60) for correct behaviors. A negative correlation between total knowledge and behavior was found (p < 0.001, r = -0.543). Conclusions: In epidemics, standard protection measures should be known and applied. Regarding this topic, the web page of the Ministry of Health comes to the forefront as a reliable source of information in addition to scientific explanations.Öğe The Evaluation of the Seroprevalence of HBV and HCV Infections in Patients with Hemodialysis in Hatay City and the Assessment of Antibody Response to Hepatitis B Vaccination(Galenos Publ House, 2010) Evirgen, Omer; Onlen, Yusuf; Motor, Vicdan Koksaldi; Mahsereci, Erkan; Inci, Melek; Sahin, SulePatients with end stage renal disease (ESRD) being treated with hemodialysis (HD) usually require frequent blood transfusions and hospitalizations. Therefore, they are at high risk of hepatitis. Because of infection control programs and regular vaccinations in dialysis centers, a decrease in the prevalence of hepatitis due to HBV and HCV infections is observed in these units. The present study aimed to investigate the seroprevalence of HBV and HCV infections in patients with HD in dialysis centers of Hatay city and to assess antibody response to hepatitis B vaccination. A total of 801 HD patients were included in the study between January 01 and December 31, 2009 from seven HD centers. Data were obtained from the files retrospectively. HBsAg, anti-HBs and anti-HCV seropositivity of the patient's samples were analyzed by enzyme immunoassay method. Of the 801 HD patients included, 480 (59.9%) were male and 321 (40.1%) were female. The mean age of the patients was 58.2 +/- 14.9 years (range, 10-98 years). HBsAg was positive in 29 (3.6%) patients and anti-HCV was positive in 76 (9.5%) patients. Five (0.6%) patients had both HBsAg and anti-HCV positivity. Of the 712 patients whose anti-HBs data were available, 578 (72.2%) patients were anti-HBs positive, whereas 134 (16.7%) were not. In the present study, although a lower hepatitis B and C prevalence was found in Hatay city compared with the previous studies conducted in Turkey, our results were similar reported for European countries. However, viral hepatitis is still an important health problem in HD patients. Infection control programs, vaccination, the education of the patients and health staff may decrease the incidence ofnewinfections.Öğe Investigation of Parvovirus B19 Seroprevalence, Endothelin-1 Synthesis, and Nitric Oxide Levels in the Etiology of Essential Hypertension(Taylor & Francis Inc, 2012) Motor, Vicdan Koksaldi; Arica, Secil; Motor, Sedat; Yilmaz, Nigar; Evirgen, Omer; Inci, Melek; Gokce, CumaliBackground and Aims: Many studies have focused on the role of pathogen infection in hypertension (HT). It has been postulated that increased vascular tonus in HT is basically related to the imbalance between vasodilator, such as nitric oxide (NO), and vasoconstrictor, such as endothelin-1 (ET-1), substances secreted by endothelium. The aim of the present study was to investigate the seroprevalence of human parvovirus B19 (HPV B19) in the etiology of essential HT and the effect of HPV B19 on ET-1 and NO levels in this disorder. Materials and Methods: A total of 135 participants were enrolled in the study (90 patient and 45 controls). Antibodies to HPV B19 and ET-1 were measured by enzyme-linked immunosorbent assay method. Nitric oxide levels were calculated according to the Griess reaction. Results: Of the total participants, 27 patients (30%) and 7 control subjects (15.6%) had IgM positive (P = .068), whereas 27 patients (30%) and 14 control subjects (31.1%) had IgG positive (P = .895). There was no statistical difference between patients and control subjects in terms of serum ET-1 and NO levels. Conclusions: The role of HPV B19 in the etiology of essential HT was not shown in the present study. A larger sample may be needed for the investigation of these relations.Öğe Investigation of the association between glaucoma and Helicobacter pylori infection using the 14C-urea breath test(Consel Brasil Oftalmologia, 2015) Tuzcu, Esra Ayhan; Aydogan, Fusun; Motor, Vicdan Koksaldi; Ilhan, Ozgur; Daglioglu, Mutlu Cihan; Coskun, Mesut; Ikirer, Nihan ParlakfPurpose: To investigate the association between glaucoma and Helicobacter pylori infection by evaluating for the presence of H. pylori infection in patients with glaucoma using the C-14-urea breath test (14C-UBT). Methods: Using 14C-UBT, H. pylori infection positivity was compared between a group of patients with primary open-angle glaucoma and a control group with normal intraocular pressure and a normal optic disc or normal perimetry. Results: The 14C-UBT was positive in 18 (51.42%) out of 35 patients in the glaucoma group and in 15 (42.85%) out of 35 patients in the control group. H. pylori infection positivity rates were similar between the glaucoma and control groups (p>0.05). Conclusion: According to the 14C-UBT, there is no association between primary open-angle glaucoma and H. pylori infection.Öğe Radiological Imaging of Rare Intracranial Complications Secondary to Otitis Media and Mastoiditis(Lippincott Williams & Wilkins, 2017) Burakgazi, Gulen; Bayarogullari, Hanifi; Ozturk, Fatma; Arli, Cengiz; Motor, Vicdan Koksaldi; Yanmaz, Rasim; Atci, NesrinAcute otitis media used to cause fatal results because of its intracranial complications before the introduction of potent and effective antibiotics. After the introduction of antibiotics, complications have started to be observed more frequently as a result of chronic otitis media and especially in children. Because clinical findings changed and became indistinct, the diagnosis of otitis and mastoiditis has been made occasionally with imaging findings only after complications occurred. Multidetector computed tomography and magnetic resonance imaging are efficient and sufficient methods in the rapid diagnosis and should be immediately referred methods.Öğe Seropositivity of Hepatitis B and Hepatitis C in women who were admitted to Hatay Maternity and Children's Hospital(Galenos Yayincilik, 2010) Motor, Vicdan Koksaldi; Evirgen, Omer; Aksakal, Mehmet; Inci, Melek; Onlen, Yusuf; Ocak, SabahattinThe aim of this study was to investigate the rates of HBsAg and anti-HCV seropositivity in women in reproductive age group who were applied to our provincial maternity hospital between January 01 and December 31, 2009. Levels of HBsAg and anti-HCV determined with chemiluminescence immunoassay (Architect i2000, Abbott, USA) method were evaluated retrospectively. A total of 5410 women out of 13065 women included in the study were followed-up for pregnancy. For HBsAg, 12969 samples were analyzed and 203 (1.6%) of these samples were positive; for anti-HCV, 12784 samples were analyzed and 55 (0.4%) of these samples were positive. HBsAg and anti-HCV serology were positive in 81 (1.5%) and in 16 (0.3%) of the pregnant women, respectively. Among age groups, a significant difference was determined for HBsAg positivity, but a significant difference was not observed for anti-HCV positivity. In conclusion, all pregnant women with positive serology should be educated for precaution during delivery. Hospitals should be controlled regularly.Öğe The Seropositivity of Parvovirus B19 in Patients with Ankylosing Spondylitis(Aves, 2014) Motor, Vicdan Koksaldi; Ustun, Nilgun; Evirgen, Omer; Inci, Melek; Yula, Erkan; Onlen, YusufObjective: Parvovirus B19 is one of the most common causes of viral arthritis, which suggests that it can be a significant factor in the pathogenesis of chronic inflammatory diseases, such as rheumatoid arthritis. The aim of the present study was to investigate the seropositivity of parvovirus B19 in patients with ankylosing spondylitis (AS). Material and Methods: The patient group consisted of 43 patients with ankylosing spondylitis; the control group consisted of 70 subjects who did not have any bone joints complaints. Anti-parvovirus B19 IgM and IgG antibodies were measured by ELISA. Results: Parvovirus B19 IgM antibody positivity in patients with AS was significantly higher than that in the control group (p<0.001). Conclusion: The high frequency of anti-parvovirus B19 IgM positivity in patients with AS suggests that the virus reactivates or persists in these patients due to immuno deficiency.Öğe SEROPREVALANCE OF TOXOPLASMA IgG AMONG PREGNANT WOMEN IN THE PROVINCE OF HATAY AND CONTRIBUTION OF AVIDITY TEST TO THE DIAGNOSE(Galenos Yayincilik, 2013) Okyay, Ayfle Guler; Karateke, Atilla; Yula, Erkan; Inci, Melek; Silfeler, Dilek Benk; Motor, Vicdan KoksaldiObjective: Toxoplasma gondii, an obligate intracellular parasite, is a common zoonosis in the world and causes toxoplasmosis. The infection is usually asymptomatic and if it occurs during pregnancy it may cause congenital anomalies, miscarriage, stillbirth and premature delivery. In this study, determination of seroprevalance of Toxoplasma IgG and IgM among pregnant women in the province of Hatay was aimed. In addition, IgG avidity test was performed in subjects who had positive test results for both of the two antibodies. Design: In this study, 3340 pregnant women who admitted to the outpatient clinic of Gynecology and Obstetrics Department of Mustafa Kemal University between the years of 2007 and 2012 were included. Toxoplasma IgM and IgG antibody test results of the subjects were examined retrospectively by screening the records of microbiology laboratory of the hospital. Additionally, IgG avidity test was performed in 114 cases whose test results for both Toxoplasma IgM and IgG were positive. Main outcome measures: IgM and IgG seropositivity rates were found as 3.6% (n : 120) and 57% (n: 1910), respectively. The rate of new infection was detected with avidity test as 31%. Conclusions: Since remarkably high seropositivity rate was observed in the Mediterranean region especially in the province of Hatay, antibody testing for Toxoplasma gondii may be useful during routine examinations of women who are in this region. In addition, measures should be taken to raise awareness of hygiene in our region in terms of water and sanitation.
