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    Oxidative Stress and Acute-Phase Response Status During Treatment in Premature Calves with Respiratory Distress Syndrome
    (Hellenic Veterinary Medical Soc, 2021) Ok, M.; Yildiz, R.; Tras, B.; Coskun, P.; Akar, A.
    This study aimed to determine lipid peroxide (LPO), antioxidant capacity (AOC), and acute-phase protein changes before and after different nebulization treatments in premature calves with respiratory distress syndrome (RDS). Thirty-six premature calves were divided into equal number of 6 groups. Group 1 was labelled as negative control and received standard treatment. Group 2 was labelled as positive control; Groups 3, 4, 5, and 6 were labelled as trial groups. These groups received nebulizer treatment. Nebulizer drug combinations were as follows: Group 2 (fluticasone), Group 3 (formoterol + fluticasone), Group 4 (ipratropium bromide + fluticasone), Group 5 (fluticasone + furosemide) and Group 6 (formoterol + ipratropium bromide + furosemide + fluticasone). Venous blood was taken from all calves before (0 hour) and after treatment (24th, 48th, 72nd hour). It was concluded that total LPO levels gradually decreased while AOC levels increased during treatment but there was no difference in the serum amyloid A (SAA) and fibrinogen levels within groups. In conclusion, supportive and nebulizer treatments to improve function of lungs were demonstrated to alleviate oxidative stress. However, in order to reveal the effects of local nebulizer applications on oxidative stress, further studies are required to investigate oxidation parameters in the bronchoalveolar fluid.
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    Subclinical Myocardial Injury in Clinically Healthy Obese Dogs
    (Israel Veterinary Medical Assoc, 2020) Naseri, A.; Ider, M.; Gulersoy, E.; Koral, E.; Erturk, A.; Durgut, M. K.; Ok, M.
    The aim of this study was to evaluate the relationship between obesity and adipokines and also to determine subclinical myocardial injury by cardiac biomarkers. Twenty-five healthy obese (HO) and 15 healthy normal weight (HN) mixed breed dogs were enrolled in the study. Blood sampling and cardiologic examination were performed in all dogs in order to exclude any diseases. The HO group had higher levels of triglycerides (P<0.005), glucose (P<0.025), and lower levels of creatinine (P<0.010) compared to HN dogs. HO dogs had higher serum leptin (P<0.001) but lower adiponectin concentrations (P<0.009) than HN dogs. Systolic blood pressure (P<0.004) and serum concentration of cardiac troponin T was significantly higher in HO dogs compared to HN dogs (P<0.038). There was no statistical significance in concentrations of blood urea nitrogen, alanine aminotransferase, alkaline phosphatase, albumin, total protein, cholesterol, cardiac troponin I, and N-terminal pro brain natriuretic peptide between HO and HN dogs. The bivariate analysis revealed that triglyceride, leptin and systolic blood pressure had positive (r=0.45, P<0.01; r=0.78, P<0.001; r=0.46, P<0.05, respectively) and adiponectin had negative correlation with body condition score (r=-0.39, P<0.05). Cardiac troponin T had a positive correlation with systolic blood pressure (r=0.56, P<0.01). The findings indicate that unfavorable metabolic and lipid changes in obese dogs and systemic hypertension have harmful effects on the myocardium. Elevation of serum cardiac troponin T in obese dogs compared to healthy dogs could represent a probable subclinical myocardial damage in obese dogs.
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    Subclinical myocardial injury in clinically healthy obese dogs
    (Israel Veterinary Medical Association, 2020) Naseri, Amir; Ider, M.; Gulersoy, E.; Koral, E.; Erturk, A.; Durgut, M.K.; Ok, M.
    The aim of this study was to evaluate the relationship between obesity and adipokines and also to determine subclinical myocardial injury by cardiac biomarkers. Twenty-five healthy obese (HO) and 15 healthy normal weight (HN) mixed breed dogs were enrolled in the study. Blood sampling and cardiologic examination were performed in all dogs in order to exclude any diseases. The HO group had higher levels of triglycerides (P<0.005), glucose (P<0.025), and lower levels of creatinine (P<0.010) compared to HN dogs. HO dogs had higher serum leptin (P<0.001) but lower adiponectin concentrations (P<0.009) than HN dogs. Systolic blood pressure (P<0.004) and serum concentration of cardiac troponin T was significantly higher in HO dogs compared to HN dogs (P<0.038). There was no statistical significance in concentrations of blood urea nitrogen, alanine aminotransferase, alkaline phosphatase, albumin, total protein, cholesterol, cardiac troponin I, and N-terminal pro brain natriuretic peptide between HO and HN dogs. The bivariate analysis revealed that triglyceride, leptin and systolic blood pressure had positive (r=0.45, P<0.01; r=0.78, P<0.001; r=0.46, P<0.05, respectively) and adiponectin had negative correlation with body condition score (r=-0.39, P<0.05). Cardiac troponin T had a positive correlation with systolic blood pressure (r=0.56, P<0.01). The findings indicate that unfavorable metabolic and lipid changes in obese dogs and systemic hypertension have harmful effects on the myocardium. Elevation of serum cardiac troponin T in obese dogs compared to healthy dogs could represent a probable subclinical myocardial damage in obese dogs. © 2020, Israel Veterinary Medical Association. All rights reserved.